{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:15:18Z","timestamp":1783116918187,"version":"3.54.6"},"reference-count":36,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151316"],"award-info":[{"award-number":["82151316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81922033"],"award-info":[{"award-number":["81922033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81727805"],"award-info":[{"award-number":["81727805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SGDX 20190917094601717"],"award-info":[{"award-number":["SGDX 20190917094601717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ 20210324141216040"],"award-info":[{"award-number":["JCYJ 20210324141216040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology","award":["82151316"],"award-info":[{"award-number":["82151316"]}]},{"name":"Shenzhen Science and Technology","award":["81922033"],"award-info":[{"award-number":["81922033"]}]},{"name":"Shenzhen Science and Technology","award":["81727805"],"award-info":[{"award-number":["81727805"]}]},{"name":"Shenzhen Science and Technology","award":["SGDX 20190917094601717"],"award-info":[{"award-number":["SGDX 20190917094601717"]}]},{"name":"Shenzhen Science and Technology","award":["JCYJ 20210324141216040"],"award-info":[{"award-number":["JCYJ 20210324141216040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Right ventricular (RV) function is one of the critical factors affecting the prognosis of fetuses with hypoplastic left heart syndrome (HLHS). Our study objectives included assessment of cardiac function and comprehensive measurement of cardiac microstructure. We retrospectively studied 42 fetuses diagnosed as HLHS by echocardiography. Myocardial deformation of the right ventricular wall was calculated automatically in offline software. Postmortem cardiac imaging for three control fetal hearts and four HLHS specimens was performed by a 9.4T DTI scanner. Myocardial deformation parameters of the RV (including strain, strain rate, and velocity) were significantly lower in HLHS fetuses (all p &lt; 0.01). FA values increased (0.18 \u00b1 0.01 vs. 0.21 \u00b1 0.02; p &lt; 0.01) in HLHS fetuses, but MD reduced (1.3 \u00b1 0.15 vs. 0.88 \u00b1 0.13; p &lt; 0.001). The HLHS fetuses\u2019 RV lateral base wall (\u22127.31 \u00b1 51.91 vs. \u22126.85 \u00b1 31.34; p = 0.25), middle wall (1.71 \u00b1 50.92 vs. \u22129.38 \u00b1 28.18; p &lt; 0.001), and apical wall (\u22126.19 \u00b1 46.61 vs. \u221211.16 \u00b1 29.86, p &lt; 0.001) had HA gradient ascent but HA gradient descent in the anteroseptal wall (p &lt; 0.001) and inferoseptal wall (p &lt; 0.001). RV basal lateral wall HA degrees were correlated with RVGLS (R2 = 0.97, p = 0.02). MD values were positively correlated with RVGLS (R2 = 0.93, p = 0.04). Our study found morphological and functional changes of the RV in HLHS fetuses, and cardiac function was related to the orientation patterns of myocardial fibers. It may provide insight into understanding the underlying mechanisms of impaired RV performance in HLHS.<\/jats:p>","DOI":"10.3390\/jcm11154456","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T02:06:42Z","timestamp":1659319602000},"page":"4456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Right Ventricular Function and Myocardial Microstructure in Fetal Hypoplastic Left Heart Syndrome"],"prefix":"10.3390","volume":"11","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-1512","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Optics Valley Laboratory, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1031-3276","authenticated-orcid":false,"given":"Jiawei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5580-7907","authenticated-orcid":false,"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Optics Valley Laboratory, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-1567","authenticated-orcid":false,"given":"Mingxing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e006983","DOI":"10.1161\/CIRCIMAGING.117.006983","article-title":"Prognostic Value of Serial Echocardiography in Hypoplastic Left Heart Syndrome","volume":"11","author":"Son","year":"2018","journal-title":"Circulation Cardiovasc. 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Reson."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/15\/4456\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:09Z","timestamp":1760140809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/15\/4456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":36,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jcm11154456"],"URL":"https:\/\/doi.org\/10.3390\/jcm11154456","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,30]]}}}