{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:16:56Z","timestamp":1793823416063,"version":"4.6.1"},"reference-count":85,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Recent literature has stressed the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). Women with PCOS are deficient in VD, particularly those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, and reduced levels of VD is associated with insulin resistance and increased diabetes risk. Since women with PCOS and hirsutism seem to have lower levels of VD than women with PCOS without hirsutism, a correlation between VD deficiency and hyperandrogenism may be suggested. Interestingly, VD is crucial for many human physiological functions, including to counteract inflammation and oxidative stress. Some studies evaluated effects of VD supplementation on glucose homeostasis variables, hormonal status, lipid concentrations, and biomarkers of inflammation and oxidative stress among VD-deficient women. Moreover, VD has been shown to play a role in egg quality and fertility. This review aims to show the relationship between VD and the endocrine and metabolic profile of PCOS patients, as well as its implications for their fertility. The supplement of VD to the common therapy can lead to an improvement of the insulin resistance and lipid metabolism, a reduction of circulating androgens, as well as a better response to the induction of ovulation in PCOS women.<\/jats:p>","DOI":"10.3390\/jcm11154509","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T21:41:37Z","timestamp":1659476497000},"page":"4509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-2321","authenticated-orcid":false,"given":"Giuseppe","family":"Morgante","sequence":"first","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Darino","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Span\u00f2","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luisi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-7336","authenticated-orcid":false,"given":"Alice","family":"Luddi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-7028","authenticated-orcid":false,"given":"Paola","family":"Piomboni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-9548","authenticated-orcid":false,"given":"Laura","family":"Governini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Leo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.fertnstert.2016.05.009","article-title":"Introduction: Determinants of Polycystic Ovary Syndrome","volume":"106","author":"Azziz","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum. Reprod. Oxf. Engl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, Hormonal and Metabolic Aspects of PCOS: An Update","volume":"14","author":"Musacchio","year":"2016","journal-title":"Reprod. Biol. Endocrinol. RBE"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Teede, H., Deeks, A., and Moran, L. (2010). Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive and Metabolic Manifestations That Impacts on Health across the Lifespan. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-41"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/humupd\/dmr001","article-title":"PCOS, Coronary Heart Disease, Stroke and the Influence of Obesity: A Systematic Review and Meta-Analysis","volume":"17","author":"Dekkers","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"ref_6","first-page":"e25076","article-title":"Cardio-Metabolic Disease and Polycystic Ovarian Syndrome (PCOS): A Narrative Review","volume":"14","author":"Sangaraju","year":"2022","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/EJE-09-0432","article-title":"Association of Hypovitaminosis D with Metabolic Disturbances in Polycystic Ovary Syndrome","volume":"161","author":"Wehr","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shi, X.-Y., Huang, A.-P., Xie, D.-W., and Yu, X.-L. (2019). Association of Vitamin D Receptor Gene Variants with Polycystic Ovary Syndrome: A Meta-Analysis. BMC Med. Genet., 20.","DOI":"10.1186\/s12881-019-0763-5"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Armanini, D., Boscaro, M., Bordin, L., and Sabbadin, C. (2022). Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084110"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Smirnov, V.V., Beeraka, N.M., Butko, D.Y., Nikolenko, V.N., Bondarev, S.A., Achkasov, E.E., Sinelnikov, M.Y., and Sinelnikov, P.R.H. (2022). Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS. Reprod. Sci. Thousand Oaks Calif, online ahead of print.","DOI":"10.1007\/s43032-022-01013-x"},{"key":"ref_11","first-page":"15","article-title":"Natural Molecules for the Therapy of Hyperandrogenism and Metabolic Disorders in PCOS","volume":"21","author":"Cappelli","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"(2004). Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS). Hum. Reprod. Oxf. Engl., 19, 41\u201347.","DOI":"10.1093\/humrep\/deh098"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/1933719114522525","article-title":"Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology","volume":"21","author":"Clark","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1530\/JOE-20-0155","article-title":"Hyperandrogenism and Insulin Resistance Modulate Gravid Uterine and Placental Ferroptosis in PCOS-like Rats","volume":"246","author":"Zhang","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1477-7827-4-16","article-title":"The Role of Steroids in Follicular Growth","volume":"4","author":"Drummond","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1042\/BCJ20160124","article-title":"Insulin Signalling and Glucose Transport in the Ovary and Ovarian Function during the Ovarian Cycle","volume":"473","author":"Dupont","year":"2016","journal-title":"Biochem. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-1-4684-5101-6_24","article-title":"The Metabolism and Functions of Vitamin D","volume":"196","author":"DeLuca","year":"1986","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"bvz038","DOI":"10.1210\/jendso\/bvz038","article-title":"Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level","volume":"4","author":"Bikle","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.33549\/physiolres.934266","article-title":"Vitamin D3 Action within the Ovary-an Updated Review","volume":"69","author":"Grzesiak","year":"2020","journal-title":"Physiol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/endo.141.4.7403","article-title":"Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads","volume":"141","author":"Kinuta","year":"2000","journal-title":"Endocrinology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.fertnstert.2009.05.002","article-title":"Genetic Variation in the Vitamin D Receptor and Polycystic Ovary Syndrome Risk","volume":"92","author":"Mahmoudi","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1055\/a-1587-9336","article-title":"Polymorphisms of Vitamin D Receptor and the Effect on Metabolic AndEndocrine Abnormalities in Polycystic Ovary Syndrome: A Review","volume":"53","author":"Vulcan","year":"2021","journal-title":"Horm. Metab. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.3390\/nu7064555","article-title":"Serum Vitamin D Levels and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"7","author":"He","year":"2015","journal-title":"Nutrients"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.23736\/S0391-1977.18.02824-9","article-title":"Associations between Vitamin D Levels and Polycystic Ovary Syndrome Phenotypes","volume":"44","author":"Davis","year":"2019","journal-title":"Minerva Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-0043-107242","article-title":"The Effects of Vitamin D Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"49","author":"Maktabi","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000362414","article-title":"Activation of the Hypothalamic-Pituitary-Gonadal Axis in Infancy: Minipuberty","volume":"82","author":"Sankilampi","year":"2014","journal-title":"Horm. Res. Paediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/cen.13856","article-title":"Evaluation of Vitamin D Status and Its Correlation with Gonadal Function in Children at Mini-Puberty","volume":"90","author":"Atay","year":"2019","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1210\/jc.2013-3873","article-title":"Association between Sex Steroids, Ovarian Reserve, and Vitamin D Levels in Healthy Nonobese Women","volume":"99","author":"Chang","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2006-948308","article-title":"Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Insulin Resistance and Obesity in Women with Polycystic Ovary Syndrome","volume":"114","author":"Hahn","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.12688\/f1000research.4714.1","article-title":"Vitamin D as a Regulator of Steroidogenic Enzymes","volume":"3","author":"Lundqvist","year":"2014","journal-title":"F1000Research"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3109\/09513590.2012.696753","article-title":"Therapeutic Implications of Vitamin D and Calcium in Overweight Women with Polycystic Ovary Syndrome","volume":"28","author":"Pal","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.fertnstert.2014.04.046","article-title":"Role of Vitamin D in Ovarian Physiology and Its Implication in Reproduction: A Systematic Review","volume":"102","author":"Irani","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/erm.2016.4","article-title":"Protein Pathways Working in Human Follicular Fluid: The Future for Tailored IVF?","volume":"18","author":"Bianchi","year":"2016","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/19396368.2017.1296046","article-title":"Modulation of Steroidogenesis by Vitamin D3 in Granulosa Cells of the Mouse Model of Polycystic Ovarian Syndrome","volume":"63","author":"Bakhshalizadeh","year":"2017","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.theriogenology.2017.08.002","article-title":"Vitamin D Receptor Expression and Potential Role of Vitamin D on Cell Proliferation and Steroidogenesis in Goat Ovarian Granulosa Cells","volume":"102","author":"Yao","year":"2017","journal-title":"Theriogenology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1124\/mol.65.3.720","article-title":"Dehydroepiandrosterone Sulfotransferase Is a Target for Transcriptional Induction by the Vitamin D Receptor","volume":"65","author":"Echchgadda","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1472-6483(10)62005-6","article-title":"Novel Follicular Fluid Factors Influencing Oocyte Developmental Potential in IVF: A Review","volume":"12","author":"Baka","year":"2006","journal-title":"Reprod. Biomed. Online"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105521","DOI":"10.1016\/j.jsbmb.2019.105521","article-title":"Effects of Vitamin D on Steroidogenesis, Reactive Oxygen Species Production, and Enzymatic Antioxidant Defense in Human Granulosa Cells of Normal and Polycystic Ovaries","volume":"197","author":"Masjedi","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"E1137","DOI":"10.1210\/jc.2013-4161","article-title":"Vitamin D Alters Genes Involved in Follicular Development and Steroidogenesis in Human Cumulus Granulosa Cells","volume":"99","author":"Merhi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13048-015-0131-9","article-title":"Use of Aromatase Inhibitors in Practice of Gynecology","volume":"8","author":"Usluogullari","year":"2015","journal-title":"J. Ovarian Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1210\/en.2009-0855","article-title":"Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy","volume":"151","author":"Krishnan","year":"2010","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mce.2018.08.010","article-title":"Crosstalk between Advanced Glycation End Products and Vitamin D: A Compelling Paradigm for the Treatment of Ovarian Dysfunction in PCOS","volume":"479","author":"Merhi","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/molehr\/gay014","article-title":"Advanced Glycation End Products Alter Steroidogenic Gene Expression by Granulosa Cells: An Effect Partially Reversible by Vitamin D","volume":"24","author":"Merhi","year":"2018","journal-title":"MHR Basic Sci. Reprod. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2019). Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology, 8.","DOI":"10.3390\/biology8020030"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/ijpvm.IJPVM_576_17","article-title":"Oxidative Stress and Polycystic Ovary Syndrome: A Brief Review","volume":"10","author":"Mohammadi","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_47","first-page":"8136","article-title":"Metformin Doses and Body Mass Index: Clinical Outcomes in Insulin Resistant Polycystic Ovary Syndrome Women","volume":"24","author":"Morgante","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_48","first-page":"53","article-title":"Polycystic Ovary Syndrome and Type 2 Diabetes Mellitus","volume":"56","author":"Musacchio","year":"2004","journal-title":"Minerva Ginecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/EJE-11-0984","article-title":"Vitamin D and Fertility: A Systematic Review","volume":"166","author":"Lerchbaum","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1210\/jc.2007-0298","article-title":"The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis","volume":"92","author":"Pittas","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01269910","article-title":"The Role of Calcium and Magnesium in Insulin Secretion from Rabbit Pancreas Studied in Vitro","volume":"3","author":"Milner","year":"1967","journal-title":"Diabetologia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/GCO.0000000000000065","article-title":"Vitamin D and Female Fertility","volume":"26","author":"Lerchbaum","year":"2014","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cbf.951","article-title":"Transcriptional Activation of the Human Insulin Receptor Gene by 1,25-Dihydroxyvitamin D(3)","volume":"20","author":"Maestro","year":"2002","journal-title":"Cell Biochem. Funct."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1210\/jc.2010-2388","article-title":"Vitamin D Status, Adiposity, and Lipids in Black American and Caucasian Children","volume":"96","author":"Rajakumar","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1017\/S1368980013001225","article-title":"Association of Vitamin D Insufficiency with Adiposity and Metabolic Disorders in Brazilian Adolescents","volume":"17","author":"Oliveira","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1475-2840-11-149","article-title":"Plasma Vitamin D and Parathormone Are Associated with Obesity and Atherogenic Dyslipidemia: A Cross-Sectional Study","volume":"11","author":"Guasch","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3109\/01443615.2015.1103715","article-title":"Impact of Hypovitaminosis D on Clinical, Hormonal and Insulin Sensitivity Parameters in Normal Body Mass Index Polycystic Ovary Syndrome Women","volume":"36","author":"Ganie","year":"2016","journal-title":"J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"351385","DOI":"10.1155\/2010\/351385","article-title":"Role of Vitamin d in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis","volume":"2010","author":"Alvarez","year":"2010","journal-title":"Int. J. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.metabol.2011.03.002","article-title":"Vitamin D Deficiency Is Common and Associated with Metabolic Risk Factors in Patients with Polycystic Ovary Syndrome","volume":"60","author":"Li","year":"2011","journal-title":"Metabolism."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.niox.2011.06.005","article-title":"Determinants of Insulin Responsiveness in Young Women: Impact of Polycystic Ovarian Syndrome, Nitric Oxide, and Vitamin D","volume":"25","author":"Ngo","year":"2011","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09513590.2019.1625881","article-title":"Effects of Vitamin D Supplementation in Women with Polycystic Ovary Syndrome: A Review","volume":"36","author":"Menichini","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_62","first-page":"268","article-title":"The role of vitamin D in assisted reproduction techniques","volume":"70","author":"Cappelli","year":"2018","journal-title":"Minerva Ginecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3945\/ajcn.112.050013","article-title":"Correcting Vitamin D Insufficiency Improves Insulin Sensitivity in Obese Adolescents: A Randomized Controlled Trial","volume":"97","author":"Belenchia","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00404-009-0958-7","article-title":"Serum 25-Hydroxyvitamin D Concentrations in Obese and Non-Obese Women with Polycystic Ovary Syndrome","volume":"280","author":"Yildizhan","year":"2009","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1530\/EJE-11-1070","article-title":"Parameters for Calcium Metabolism in Women with Polycystic Ovary Syndrome Who Undergo Clomiphene Citrate Stimulation: A Prospective Cohort Study","volume":"166","author":"Ott","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/09513590.2014.927857","article-title":"Insulin and Body Weight but Not Hyperandrogenism Seem Involved in Seasonal Serum 25-OH-Vitamin D3 Levels in Subjects Affected by PCOS","volume":"30","author":"Gallea","year":"2014","journal-title":"Gynecol. Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0960-0760(03)00032-3","article-title":"Identification of a Vitamin D Response Element in the Human Insulin Receptor Gene Promoter","volume":"84","author":"Maestro","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/jc.2008-1454","article-title":"Nonclassic Actions of Vitamin D","volume":"94","author":"Bikle","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, Inflammation, and Insulin Resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-0044-101355","article-title":"The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"50","author":"Akbari","year":"2018","journal-title":"Horm. Metab. Res. Horm. Stoffwechselforschung Horm. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/cen.12840","article-title":"Calcium plus Vitamin D Supplementation Influences Biomarkers of Inflammation and Oxidative Stress in Overweight and Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial","volume":"83","author":"Foroozanfard","year":"2015","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13048-019-0480-x","article-title":"Vitamin D and Probiotic Co-Supplementation Affects Mental Health, Hormonal, Inflammatory and Oxidative Stress Parameters in Women with Polycystic Ovary Syndrome","volume":"12","author":"Ostadmohammadi","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3945\/jn.115.218883","article-title":"Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial","volume":"146","author":"Sepehrmanesh","year":"2016","journal-title":"J. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1028-4559(09)60275-8","article-title":"The Effects of Calcium-Vitamin D and Metformin on Polycystic Ovary Syndrome: A Pilot Study","volume":"48","author":"Rashidi","year":"2009","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"219","DOI":"10.11613\/BM.2011.031","article-title":"Anti-M\u00fcllerian Hormone: A Unique Biochemical Marker of Gonadal Development and Fertility in Humans","volume":"21","author":"Zec","year":"2011","journal-title":"Biochem. Medica"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"bqaa023","DOI":"10.1210\/endocr\/bqaa023","article-title":"Roles of Vitamin D in Reproductive Systems and Assisted Reproductive Technology","volume":"161","author":"Chen","year":"2020","journal-title":"Endocrinology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ctcp.2016.11.008","article-title":"Effect of Vitamin D Supplementation on Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"26","author":"Fang","year":"2017","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kollmann, M., Obermayer-Pietsch, B., Lerchbaum, E., Feigl, S., Hochst\u00e4tter, R., Pregartner, G., Trummer, C., and Klaritsch, P. (2021). Vitamin D Concentrations at Term Do Not Differ in Newborns and Their Mothers with and without Polycystic Ovary Syndrome. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030537"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1210\/jc.2012-1213","article-title":"The Level of Serum Anti-M\u00fcllerian Hormone Correlates with Vitamin D Status in Men and Women but Not in Boys","volume":"97","author":"Dennis","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1210\/en.2008-1555","article-title":"Interaction of the Vitamin D Receptor with a Vitamin D Response Element in the Mullerian-Inhibiting Substance (MIS) Promoter: Regulation of MIS Expression by Calcitriol in Prostate Cancer Cells","volume":"150","author":"Malloy","year":"2009","journal-title":"Endocrinology"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Holzer, I., Parry, J.P., Beitl, K., Pozderovic, B., Marculescu, R., and Ott, J. (2022). Parameters for Calcium Metabolism in Women with Polycystic Ovary Syndrome Who Undergo Stimulation with Letrozole: A Prospective Cohort Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092597"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ctcp.2012.01.005","article-title":"Therapeutic Effects of Calcium & Vitamin D Supplementation in Women with PCOS","volume":"18","author":"Aflatoonian","year":"2012","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-14-0253","article-title":"The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology","volume":"171","author":"Conway","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.fertnstert.2010.12.027","article-title":"Lipid Levels in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis","volume":"95","author":"Wild","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e3644","DOI":"10.1210\/clinem\/dgab296","article-title":"Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly","volume":"106","author":"Bacha","year":"2021","journal-title":"J. Clin. Endocrinol. 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