{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:30:23Z","timestamp":1782257423248,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Atrial fibrillation is the most common sustained cardiac arrhythmia in adults. It is a complex arrhythmia leading to increased morbidity and mortality requiring thorough assessment and classification to guide therapy and to assess whether to pursue rate or rhythm control therapy. To obtain rhythm control, several strategies are available with different advantages and disadvantages concerning success rate and safety. Apart from antiarrhythmic drugs, catheter ablation is a well-established invasive therapy to treat atrial fibrillation. As quality of life is a very important factor to pursue rhythm control, several studies investigated on the specific impact of catheter ablation on quality of life. Catheter ablation shows a beneficial effect on quality of life in paroxysmal and persistent atrial fibrillation independent of the timepoint and strategy of catheter ablation.<\/jats:p>","DOI":"10.3390\/jcm11154541","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T21:52:48Z","timestamp":1659649968000},"page":"4541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Catheter Ablation for Atrial Fibrillation on Quality of Life"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-6362","authenticated-orcid":false,"given":"Ursula","family":"Rohrer","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-4373","authenticated-orcid":false,"given":"Martin","family":"Manninger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zirlik","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Scherr","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"ref_1","first-page":"373","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Hindricks","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e13825","DOI":"10.1111\/eci.13825","article-title":"Clinical utility and prognostic implications of the 4S-AF scheme: Report from Asia Pacific Heart Rhythm Society Atrial Fibrillation Registry","volume":"14","author":"Chao","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/europace\/euab280","article-title":"Clinical utility and prognostic implications of the novel 4S-AF scheme to characterize and evaluate patients with atrial fibrillation: A report from ESC-EHRA EORP-AF Long-Term General Registry","volume":"24","author":"Ding","year":"2022","journal-title":"Europace"},{"key":"ref_4","first-page":"270","article-title":"The 4S-AF Scheme (Stroke Risk; Symptoms; Severity of Burden; Substrate): A Novel Approach to In-Depth Characterization (Rather than Classification) of Atrial Fibrillation","volume":"121","author":"Potpara","year":"2020","journal-title":"Thromb. Haemost."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/europace\/eux275","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary","volume":"20","author":"Calkins","year":"2018","journal-title":"Europace"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/jama.2019.0692","article-title":"Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial","volume":"321","author":"Mark","year":"2019","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/eurheartj\/eht457","article-title":"Catheter ablation vs. antiarrhythmic drug treatment of persistent atrial fibrillation: A multicentre, randomized, controlled trial (SARA study)","volume":"35","author":"Mont","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0002-9149(97)00396-2","article-title":"Pilot study and protocol of the Canadian Trial of Atrial Fibrillation (CTAF)","volume":"80","author":"Roy","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/europace\/euu342","article-title":"Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation: Results on health-related quality of life and symptom burden. The MANTRA-PAF trial","volume":"17","author":"Walfridsson","year":"2015","journal-title":"Europace"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1001\/jama.293.21.2634","article-title":"Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: A randomized trial","volume":"293","author":"Wazni","year":"2005","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1161\/CIRCULATIONAHA.108.772582","article-title":"Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: The A4 study","volume":"118","author":"Cauchemez","year":"2008","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/jama.2009.2029","article-title":"Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: A randomized controlled trial","volume":"303","author":"Wilber","year":"2010","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/CIRCOUTCOMES.110.957563","article-title":"Improvements in symptoms and quality of life in patients with paroxysmal atrial fibrillation treated with radiofrequency catheter ablation versus antiarrhythmic drugs","volume":"3","author":"Reynolds","year":"2010","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.2019.0335","article-title":"Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients With Atrial Fibrillation: The CAPTAF Randomized Clinical Trial","volume":"321","author":"Gizurarson","year":"2019","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/jama.2014.467","article-title":"Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation (RAAFT-2): A randomized trial","volume":"311","author":"Morillo","year":"2014","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJMoa0708234","article-title":"Pulmonary-vein isolation for atrial fibrillation in patients with heart failure","volume":"359","author":"Khan","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/pace.12772","article-title":"The Impact of Duration of Atrial Fibrillation Recurrences on Measures of Health-Related Quality of Life and Symptoms","volume":"39","author":"Joza","year":"2016","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/HCQ.0000000000000011","article-title":"Health-related quality of life in patients with atrial fibrillation treated with rhythm control versus rate control: Insights from a prospective international registry (Registry on Cardiac Rhythm Disorders Assessing the Control of Atrial Fibrillation: RECORD-AF)","volume":"7","author":"Ha","year":"2014","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sethi, N.J., Feinberg, J., Nielsen, E.E., Safi, S., Gluud, C., and Jakobsen, J.C. (2017). The effects of rhythm control strategies versus rate control strategies for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and Trial Sequential Analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186856"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1056\/NEJMoa1113566","article-title":"Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation","volume":"367","author":"Johannessen","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000881","DOI":"10.1161\/JAHA.114.000881","article-title":"Improvement in quality of life after catheter ablation for paroxysmal versus long-standing persistent atrial fibrillation: A prospective study with 3-year follow-up","volume":"3","author":"Fiala","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/jce.12467","article-title":"Catheter ablation of asymptomatic longstanding persistent atrial fibrillation: Impact on quality of life, exercise performance, arrhythmia perception, and arrhythmia-free survival","volume":"25","author":"Mohanty","year":"2014","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.cjca.2013.06.006","article-title":"Relationship of quality of life with procedural success of atrial fibrillation (AF) ablation and postablation AF burden: Substudy of the STAR AF randomized trial","volume":"29","author":"Mantovan","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/eurheartj\/ehq041","article-title":"Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF): A randomized, multicentre, international trial","volume":"31","author":"Verma","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ahj.2016.10.018","article-title":"Cardioversion and subsequent quality of life and natural history of atrial fibrillation","volume":"185","author":"Pokorney","year":"2017","journal-title":"Am. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter Ablation for Atrial Fibrillation with Heart Failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa1408288","article-title":"Approaches to Catheter Ablation for Persistent Atrial Fibrillation","volume":"372","author":"Verma","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1136\/heartjnl-2020-316612","article-title":"Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation","volume":"106","author":"Piccini","year":"2020","journal-title":"Heart"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.jacc.2010.01.040","article-title":"Long-term quality of life after ablation of atrial fibrillation the impact of recurrence, symptom relief, and placebo effect","volume":"55","author":"Wokhlu","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1540-8159.2009.02357.x","article-title":"Symptomatic and asymptomatic atrial fibrillation after pulmonary vein ablation and the impact on quality of life","volume":"32","author":"Pontoppidan","year":"2009","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jacc.2016.04.015","article-title":"Impact of Rotor Ablation in Nonparoxysmal Atrial Fibrillation Patients: Results From the Randomized OASIS Trial","volume":"68","author":"Mohanty","year":"2016","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/15\/4541\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:03:56Z","timestamp":1760141036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/15\/4541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":31,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jcm11154541"],"URL":"https:\/\/doi.org\/10.3390\/jcm11154541","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]}}}