{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:33:42Z","timestamp":1783380822722,"version":"3.54.6"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Gda\u0144sk"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The term mastocytosis refers to a heterogeneous group of disorders characterised by accumulation of clonal mast cells in different organs, most commonly in the skin. Little is known about the role of dermoscopy in the diagnostics of mastocytosis. To date, no systematic review on the dermoscopic features of cutaneous mastocytosis has been performed. The aim of this study was to summarise the current knowledge in the field as well as to identify the knowledge gaps to show possible directions for further studies, based on a systematic search of PubMed, Scopus, and Web of Science databases and related references published before 3 January 2022. Dermoscopic features, type of dermoscope, polarisation mode, magnification, and number of cases were analysed. In total, 16 articles were included in this review (3 case series and 13 case reports), analysing 148 patients with different variants of cutaneous mastocytosis; all of the studies analysed had a low level of evidence (V). The main dermoscopic features of urticaria pigmentosa included brown structureless areas, brown lines arranged in a network, and linear vessels distributed in a reticular pattern, with this last finding also being typical of telangiectasia macularis eruptiva perstans. The presence of either circumscribed yellow structureless areas or diffuse yellowish background was a constant pattern of mastocytoma, while nodular, pseudoangiomatous xanthelasmoid, and plaque-type mastocytosis were typified by light-brown structureless areas and\/or pigment network, though the first two variants also showed yellow\/yellow-orange structureless areas. Finally, pigmented streaks of radial distribution surrounding hair follicles were described to be a pathognomonic dermoscopic feature of pseudoxanthomatous mastocytosis. Although this review shows that the various clinical forms of cutaneous mastocytosis may feature diagnostic dermoscopic clues, it also underlines the need for further investigation as several relevant data are missing, including evaluation of dermoscopic pattern according to anatomical locations or \u201clesion age\u201d, studies on rare mastocytosis variants, evaluation of the prognostic role of dermoscopy in the context of systemic involvement, and comparative analyses with common clinical mimickers.<\/jats:p>","DOI":"10.3390\/jcm11164649","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:42:53Z","timestamp":1660099373000},"page":"4649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dermoscopic Features of Different Forms of Cutaneous Mastocytosis: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-5675","authenticated-orcid":false,"given":"Martyna","family":"S\u0142awi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, 97-331 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kaszuba","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, 97-331 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, 97-331 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4768-1387","authenticated-orcid":false,"given":"Roman J.","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, 97-331 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Sobjanek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, 97-331 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Errichetti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universita degli Studi di Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Valent, P., Akin, C., Gleixner, K.V., Sperr, W.R., Reiter, A., Arock, M., and Triggiani, M. (2019). Multidisciplinary challenges in mastocytosis and how to address with personalized medicine approaches. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20122976"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jaci.2015.08.034","article-title":"Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma &; Immunology; and the European Academy of Allergology and Clinical Immunology","volume":"137","author":"Hartmann","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.iac.2014.01.003","article-title":"Epidemiology, prognosis, and risk factors in mastocytosis","volume":"34","author":"Brockow","year":"2014","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lange, M., Hartmann, K., Carter, M., Siebenhaar, F., Alvarez-Twose, I., Torrado, I., Brockow, K., Renke, J., Irga-Jaworska, N., and Plata-Nazar, K. (2021). Molecular Background, Clinical Features and Management of Pediatric Mastocytosis: Status 2021. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052586"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1590\/abd1806-4841.20188039","article-title":"Dermoscopic findings of pseudoxanthomatous mastocytosis localised on vulva","volume":"93","author":"Li","year":"2018","journal-title":"An. Bras. de Dermatol."},{"key":"ref_7","first-page":"e261","article-title":"Pseudoangiomatous Xanthelasmoid Mastocytosis\u2014A New Histopathological Entity","volume":"31","author":"Salah","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1111\/ijd.14385","article-title":"Palmoplantar maculopapular cutaneous mastocytosis","volume":"58","author":"Sammut","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/archdermatol.2011.190","article-title":"Dermoscopic features of skin lesions in patients with mastocytosis","volume":"147","author":"Morgado","year":"2011","journal-title":"Arch Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000182260","article-title":"Dermatoscopic findings of cutaneous mastocytosis","volume":"218","author":"Akay","year":"2008","journal-title":"Dermatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/idoj.IDOJ_312_18","article-title":"Dermoscopy of Telangiectasia Macularis Eruptiva Perstans","volume":"11","author":"Kumar","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1590\/abd1806-4841.20132053","article-title":"Dermatoscopic findings in telangiectasia macularis eruptiva perstans","volume":"88","author":"Unterstell","year":"2013","journal-title":"An. Bras. de Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/all.12013","article-title":"Extensive blistering is a predictor for severe complications in children with mastocytosis","volume":"67","author":"Brockow","year":"2012","journal-title":"Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000362755","article-title":"Bullous mastocytosis mimicking congenital epidermolysis bullosa","volume":"6","year":"2014","journal-title":"Case Rep. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/j.1468-3083.2011.04350.x","article-title":"Diffuse cutaneus mastocytosis: Analysis of 10 cases and a brief review of the literature","volume":"26","author":"Lange","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s13555-020-00455-y","article-title":"Dermoscopy in Monitoring and Predicting Therapeutic Response in General Dermatology (Non-Tumoral Dermatoses): An Up-To-Date Overview","volume":"10","author":"Errichetti","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_17","unstructured":"Oxford Centre for Evidence-Based Medicine (2022, June 03). The Oxford 2011 Levels of Evidence. Available online: http:\/\/www.cebm.net\/index.aspx?o=5653."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/bjd.18125","article-title":"Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non-neoplastic dermatoses): An expert consensus on behalf of the International Dermoscopy Society","volume":"182","author":"Errichetti","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_19","first-page":"15","article-title":"Letter: Cutaneous mastocytosis with systemic involvement mimicking clinical and dermatoscopically multiple melanocytic nevi","volume":"17","author":"Ginarte","year":"2011","journal-title":"Dermatol. Online J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1590\/abd1806-4841.20132217","article-title":"Dermatoscopic findings of urticaria pigmentosa","volume":"88","author":"Miller","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4103\/idoj.IDOJ_501_18","article-title":"Dermatoscopy of Urticaria Pigmentosa with and without Darier\u2019s Sign in Skin of Colour","volume":"10","author":"Nirmal","year":"2019","journal-title":"Indian Dermatol. Online J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/idoj.IDOJ_438_18","article-title":"Dermoscopy of Urticaria Pigmentosa","volume":"11","author":"Chauhan","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1111\/ijd.15507","article-title":"Multiple lesions with pigmented network on dermoscopy on a 1-year-old boy","volume":"60","author":"Amorim","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/idoj.IDOJ_193_17","article-title":"Dermoscopy of Cutaneous Mastocytoma","volume":"9","author":"Adya","year":"2018","journal-title":"Indian Dermatol. Online J."},{"key":"ref_25","first-page":"302","article-title":"Solitary Bullous Mastocytoma with Dermoscopic Features in a Neonate","volume":"9","author":"Yildirim","year":"2019","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e24016","DOI":"10.1136\/bcr-2020-240169","article-title":"Cutaneous mastocytosis: Clinical, dermoscopic and pathological features","volume":"13","author":"Kumar","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2021114","DOI":"10.5826\/dpc.1101a114","article-title":"Dermoscopic Demonstration of Darier Sign","volume":"11","author":"Mukherjee","year":"2021","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_28","first-page":"1","article-title":"Mastocytosis","volume":"Volume 46","author":"Griffiths","year":"2016","journal-title":"Rook\u2019s Textbook of Dermatology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1111\/jdv.13249","article-title":"Yellow and orange in cutaneous lesions: Clinical and dermoscopic data","volume":"29","author":"Arribas","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_30","first-page":"568","article-title":"Dermoscopy for the Screening of Common Urticaria and Urticaria Vasculitis","volume":"144","author":"Fueyo","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/jdv.12263","article-title":"Evolution of urticarial vasculitis: A clinical, dermoscopic and histopathological study","volume":"28","author":"Suh","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_32","first-page":"946","article-title":"Dermoscopy of Juvenile Xanthogranuloma","volume":"237","author":"Manoli","year":"2020","journal-title":"Dermatology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Di Brizzi, E.V., Moscarella, E., Scharf, C., Argenziano, G., and Piccolo, V. (2022). Dermoscopy of juvenile xanthogranuloma: A retrospective descriptive study on 35 paediatric patients. J. Eur. Acad Dermatol. Venereol.","DOI":"10.1111\/jdv.18316"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000106586","article-title":"Dermoscopic appearance of juvenile xanthogranuloma","volume":"215","author":"Palmer","year":"2007","journal-title":"Dermatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000089015","article-title":"Dermoscopy in general dermatology","volume":"212","author":"Zalaudek","year":"2006","journal-title":"Dermatology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s13555-016-0141-6","article-title":"Dermatoscopy in general dermatology: A practical overview","volume":"6","author":"Errichetti","year":"2016","journal-title":"Dermatol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/idoj.IDOJ_559_20","article-title":"Entodermoscopy update: A contemporary review on dermoscopy of cutaneous infections and infestations","volume":"12","author":"Bosseila","year":"2021","journal-title":"Indian Dermatol. Online J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Chauhan, P., Jindal, R., and Errichetti, E. (2022). Dermoscopy of skin parasitoses, bites and stings: A systematic review of the literature. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.18352"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Brazel, M., Desai, A., Are, A., and Motaparthi, K. (2021). Staphylococcal Scalded Skin Syndrome and Bullous Impetigo. Medicina, 57.","DOI":"10.3390\/medicina57111157"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/ajd.13695","article-title":"Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review","volume":"63","author":"Guida","year":"2021","journal-title":"Australas. J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/ijd.IJD_294_20","article-title":"Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders","volume":"66","author":"Narkhede","year":"2021","journal-title":"Indian J. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.clindermatol.2019.10.013","article-title":"Dermatoscopy in life-threatening and severe acute rashes","volume":"38","author":"Errichetti","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/1346-8138.13281","article-title":"Adult case of staphylococcalscalded skin syndrome differentiated from toxic epidermal necrolysis withthe aid of dermatoscopy","volume":"43","author":"Miyashita","year":"2016","journal-title":"J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2022030","DOI":"10.5826\/dpc.1201a30","article-title":"Evaluation of Dermoscopic Features in Facial Melanosis with Wood Lamp Examination","volume":"12","author":"Amatya","year":"2022","journal-title":"Dermatol. Pract. Concept."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/16\/4649\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:21Z","timestamp":1760141181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/16\/4649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":44,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jcm11164649"],"URL":"https:\/\/doi.org\/10.3390\/jcm11164649","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]}}}