{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:24:15Z","timestamp":1792448655882,"version":"4.5.0"},"reference-count":121,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Autologous fat is ideal soft tissue filler. It is easily accessible, biocompatible, cheap, and it provides both volume augmentation and skin quality improvement. Fat grafting has been used since 1893, but it has only gained widespread popularity since the development of modern liposuction by Colemann and Illouz in the 1980s. Every year more than half a million facial fat grafting procedures are carried out worldwide and the trend is rapidly increasing. Overall, general complications associated with facial fat grafting are assumed to be around 2%. Is that true? Material and Methods: Until July 2021, a systematic search of the literature was performed interrogating PubMed search engines. The following algorithm was used for the research: (fat graft OR lipofilling) AND face AND complications. Exclusion criteria applied hierarchically were review articles, not reporting recipient site complications; not in English and paediatric population. Abstracts were manually screened by LS, GS, JM and PDS separately and subsequently matched for accuracy. Pertinent full-text articles were retrieved and analysed and data were extracted from the database. The flow chart of article selection is described following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: In total, 462 papers were identified by PubMed search. A total of 359 were excluded: 38 papers were not in English, 41 were review articles, 279 articles did not report recipient site complications and 1 was not on human subjects. Average complication rate ranged from 1.5% to 81.4%. A total of 298 adverse events were identified: 40 (13.4%) intravascular injections, 13 (4.3%) asymmetry, 57 (19.1%) irregularities, 22 (7.4%) graft hypertrophy, 21 (7%) fat necrosis, 73 (24.5%) prolonged oedema, 1 (0.3%) infection, 6 (2%) prolonged erythema, 15 (5%) telangiectasia and 50 (16.8%) cases of acne activation. Conclusions: FFG related side effects could be resumed in three categories: severe, moderate, and minor. Severe (13.4%) side effects such as intravascular injection or migration require neurological or neurosurgical management and often lead to permanent disability or death. Moderate (38.3%) side effects such as fat hypertrophy, necrosis, cyst formation, irregularities and asymmetries require a retouch operation. Minor (48.3%) side effects such as prolonged oedema or erythema require no surgical management. Despite the fact that the overall general complication rate of facial fat grafting is assumed to be around 2%, the real complication rate of facial fat grafting is unknown due to a lack of reporting and the absence of consensus on side effect definition and identification. More RCTs are necessary to further determine the real complication rate of this procedure.<\/jats:p>","DOI":"10.3390\/jcm11164708","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T21:15:05Z","timestamp":1660252505000},"page":"4708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Facial Fat Grafting (FFG): Worth the Risk? A Systematic Review of Complications and Critical Appraisal"],"prefix":"10.3390","volume":"11","author":[{"given":"Luigi","family":"Schiraldi","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive Surgery, University Hospital of Lausanne (CHUV), 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Sapino","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive Surgery, University Hospital of Lausanne (CHUV), 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-3288","authenticated-orcid":false,"given":"Joachim","family":"Meuli","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive Surgery, University Hospital of Lausanne (CHUV), 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-2732","authenticated-orcid":false,"given":"Michele","family":"Maruccia","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic Surgery, University of Bari Aldo Moro, 70121 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1196-3075","authenticated-orcid":false,"given":"Mario","family":"Cherubino","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-0077","authenticated-orcid":false,"given":"Wassim","family":"Raffoul","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive Surgery, University Hospital of Lausanne (CHUV), 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro G.","family":"di Summa","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive Surgery, University Hospital of Lausanne (CHUV), 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0094-1298(20)32343-9","article-title":"Structural Fat Grafts: The Ideal Filler?","volume":"28","author":"Coleman","year":"2001","journal-title":"Clin. Plast. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/asj\/sjv030","article-title":"Autologous Fat Grafting for Cosmetic Breast Augmentation: A Systematic Review","volume":"35","author":"Voglimacci","year":"2015","journal-title":"Aesthet. Surg. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/PRS.0000000000004904","article-title":"Understanding Fatal Fat Embolism in Gluteal Lipoinjection: A Review of the Medical Records and Autopsy Reports of 16 Patients","volume":"142","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1097\/SAP.0000000000002691","article-title":"Severe Vascular Complications Caused by Facial Autologous Fat Grafting: A Critical Review","volume":"86","author":"Wang","year":"2021","journal-title":"Ann. Plast. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"502e","DOI":"10.1097\/PRS.0000000000007200","article-title":"A Changing Paradigm: The Brazilian Butt Lift Is Neither Brazilian Nor a Lift-Why It Needs to Be Called Safe Subcutaneous Buttock Augmentation","volume":"146","author":"Oranges","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/asj\/sjw240","article-title":"Gluteal Augmentation Techniques: A Comprehensive Literature Review","volume":"37","author":"Oranges","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/jamafacial.2018.0102","article-title":"Efficacy and Safety of Autologous Fat Transfer in Facial Reconstructive Surgery: A Systematic Review and Meta-Analysis","volume":"20","author":"Krastev","year":"2018","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jpra.2018.12.004","article-title":"A Systematic Review of the Effectiveness and Complications of Fat Grafting in the Facial Region","volume":"19","author":"Gornitsky","year":"2019","journal-title":"JPRAS Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.burns.2017.07.020","article-title":"Reconstruction of Neck and Face Scar Contractures Using Occipito-Cervico-Dorsal Supercharged \u201cSuper-Thin Flaps\u201d: A Retrospective Analysis of 82 Cases in Vietnam","volume":"44","author":"Vinh","year":"2018","journal-title":"Burns J. Int. Soc. Burn Inj."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"NP579","DOI":"10.1093\/asj\/sjaa324","article-title":"Autogenous Fat Transplantation and Botulinum Toxin Injection Into the Masseter Muscle to Create an Ideal Oval Face","volume":"41","author":"Zheng","year":"2021","journal-title":"Aesthet. Surg. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/asj\/sjab252","article-title":"Fat Embolism After Autologous Facial Fat Grafting","volume":"42","author":"Dhooghe","year":"2022","journal-title":"Aesthet. Surg. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"ojaa035","DOI":"10.1093\/asjof\/ojaa035","article-title":"New Mechanical Fat Separation Technique: Adjustable Regenerative Adipose-Tissue Transfer (ARAT) and Mechanical Stromal Cell Transfer (MEST)","volume":"2","author":"Copcu","year":"2020","journal-title":"Aesthetic Surg. J. Open Forum"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/SCS.0000000000006971","article-title":"Facial Reanimation by Modified Intraoral Temporalis Tendon Transfer With Ancillary Procedures","volume":"32","author":"Jose","year":"2021","journal-title":"J. Craniofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1097\/SCS.0000000000006898","article-title":"A Massive Right Hemisphere Infarction After Autologous Fat Grafting for Facial Filling","volume":"32","author":"Miao","year":"2021","journal-title":"J. Craniofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/SCS.0000000000007043","article-title":"Facial Contour Rejuvenation by Reduction Malarplasty Combined With Second-Stage Fat Grafting","volume":"32","author":"Gao","year":"2021","journal-title":"J. Craniofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/PRS.0000000000007611","article-title":"Lipofilling after Laser-Assisted Treatment for Facial Filler Complication: Volumetric and Regenerative Effect","volume":"147","author":"Pinelli","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"NP1000","DOI":"10.1093\/asj\/sjab109","article-title":"The Addition of Tissue Stromal Vascular Fraction to Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial","volume":"41","author":"Boxtel","year":"2021","journal-title":"Aesthet. Surg. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e3373","DOI":"10.1097\/GOX.0000000000003373","article-title":"Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients","volume":"9","author":"Strong","year":"2021","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/SAP.0000000000001979","article-title":"Autologous Fat Grafting in Young Patients: A Simple and Effective Way to Achieve Facial Balance","volume":"83","author":"Maia","year":"2019","journal-title":"Ann. Plast. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/PRS.0000000000006122","article-title":"Forehead Fat Grafting: Asian Facial Contouring and Augmentation","volume":"144","author":"Li","year":"2019","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"109692","DOI":"10.1016\/j.ijporl.2019.109692","article-title":"Lipofilling in Patients with a Cleft Lip (and Palate)\u2014A Pilot Study Assessing Functional Outcomes and Patients\u2019 Satisfaction with Appearance","volume":"128","author":"Alighieri","year":"2020","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00266-020-01939-0","article-title":"A Rare Vascular Complication Caused by Autologous Fat Facial Filler","volume":"44","author":"Li","year":"2020","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/asj\/sjaa066","article-title":"Ultrasound to Improve the Safety and Efficacy of Lipofilling of the Temples","volume":"41","author":"Kadouch","year":"2021","journal-title":"Aesthet. Surg. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/PRS.0000000000005220","article-title":"Facial Contour Symmetry Outcomes after Site-Specific Facial Fat Compartment Augmentation with Fat Grafting in Facial Deformities","volume":"143","author":"Denadai","year":"2019","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_25","first-page":"1374","article-title":"Objective and Subjective Evaluation of Lipoinjection for Correction of Temporal Depression","volume":"45","author":"Hu","year":"2019","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.joms.2018.12.026","article-title":"Use of a 3-Dimensional Custom-Made Porous Titanium Prosthesis for Mandibular Body Reconstruction With Prosthetic Dental Rehabilitation and Lipofilling","volume":"77","author":"Gouet","year":"2019","journal-title":"J. Oral Maxillofac. Surg. Off. J. Am. Assoc. Oral Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/jocd.13072","article-title":"Autologous Fat Transfer for Facial Recontouring in Parry-Romberg Syndrome","volume":"19","author":"Antoszewski","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00266-018-1262-3","article-title":"Corrective Strategies for a Complex Deformity Caused by \u201cEuropean-Style Double Eyelid\u201d Blepharoplasty in Asians","volume":"43","author":"Guo","year":"2019","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/SCS.0000000000005122","article-title":"Micro-Autologous Fat Transplantation Combined With Platelet-Rich Plasma for Facial Filling and Regeneration: A Clinical Perspective in the Shadow of Evidence-Based Medicine","volume":"30","author":"Ozer","year":"2019","journal-title":"J. Craniofac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1097\/SCS.0000000000005058","article-title":"Autologous Fat Injection for the Correction of Facial Depression Resulting From Silent Sinus Syndrome","volume":"30","author":"Lim","year":"2019","journal-title":"J. Craniofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/SAP.0000000000001631","article-title":"Unfiltered Nanofat Injections Rejuvenate Postburn Scars of Face","volume":"82","author":"Jan","year":"2019","journal-title":"Ann. Plast. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/ICB.0000000000000694","article-title":"Ophthalmic Artery Occlusion after Forehead Autologous Fat Injection","volume":"14","author":"Liu","year":"2020","journal-title":"Retin. Cases Brief Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/SCS.0000000000004552","article-title":"Percutaneous Autologous Fat Injection Following 2-Layer Flap Lower Blepharoplasty for the Correction of Tear Trough Deformity","volume":"29","author":"Kim","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/IOP.0000000000001167","article-title":"Phi, Fat, and the Mathematics of a Beautiful Midface","volume":"34","author":"Stein","year":"2018","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/SCS.0000000000004367","article-title":"Outcome of Conventional Adipose Tissue Grafting for Contour Deformities of Face and Role of Ex Vivo Expanded Adipose Tissue-Derived Stem Cells in Treatment of Such Deformities","volume":"29","author":"Bashir","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/PRS.0000000000003895","article-title":"Prospective Controlled Study of Chin Augmentation by Means of Fat Grafting","volume":"140","author":"Basile","year":"2017","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10006-017-0648-8","article-title":"Correction of Whistle Deformity Using Autologous Free Fat Grafting: First Results of a Pilot Study and Review of the Literature","volume":"21","author":"Baum","year":"2017","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S352","DOI":"10.1097\/SAP.0000000000001348","article-title":"Autologous Fat Grafting in the Treatment of Cleft Lip Volume Asymmetry","volume":"80","author":"Koonce","year":"2018","journal-title":"Ann. Plast. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/asj\/sjx072","article-title":"Percutaneous Myotomy With a Small Needle-Knife and Lipoinjection for Treatment of Glabellar Frown Lines","volume":"37","author":"Hu","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kim, J., Kim, S.K., and Kim, M.K. (2017). Segmental Ischaemic Infarction of the Iris after Autologous Fat Injection into the Lower Eyelid Tissue: A Case Report. BMC Ophthalmol., 17.","DOI":"10.1186\/s12886-017-0599-8"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00266-016-0692-z","article-title":"Treatment of Tear Trough Deformity: Fat Repositioning versus Autologous Fat Grafting","volume":"41","author":"Chiu","year":"2017","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00266-017-0852-9","article-title":"Vascular Age as a Predictor of Side Effects After Facial Lipofilling","volume":"41","author":"Tepavcevic","year":"2017","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1097\/SCS.0000000000003835","article-title":"Tear Trough Deformity: Study of Filling Procedures for Its Correction","volume":"28","author":"Pascali","year":"2017","journal-title":"J. Craniofac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00266-016-0681-2","article-title":"Massive Cerebral Infarction Following Facial Fat Injection","volume":"40","author":"Shen","year":"2016","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/asj\/sjv001","article-title":"Superficial Enhanced Fluid Fat Injection (SEFFI) to Correct Volume Defects and Skin Aging of the Face and Periocular Region","volume":"35","author":"Bernardini","year":"2015","journal-title":"Aesthet. Surg. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"NP147","DOI":"10.1093\/asj\/sjv015","article-title":"Ptosis: An Underestimated Complication after Autologous Fat Injection into the Upper Eyelid","volume":"35","author":"Li","year":"2015","journal-title":"Aesthet. Surg. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3928\/23258160-20150521-15","article-title":"Middle Cerebral Artery, Ophthalmic Artery, and Multibranch Retinal Vessel Occlusion After Cosmetic Autologous Fat Transfer to Forehead","volume":"46","author":"Roshandel","year":"2015","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s00266-015-0554-0","article-title":"Periorbital Lipogranuloma Following Facial Autologous Fat Injections: Non-Surgical Treatment","volume":"39","author":"Seo","year":"2015","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/1090820X14525964","article-title":"Applications of Fat Grafting in Facial Aesthetic Skeletal Surgery","volume":"34","author":"Endara","year":"2014","journal-title":"Aesthet. Surg. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"219e","DOI":"10.1097\/PRS.0000000000000409","article-title":"Double-Blind Clinical Trial to Compare Autologous Fat Grafts versus Autologous Fat Grafts with PDGF: No Effect of PDGF","volume":"134","author":"Fontdevila","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"NP83","DOI":"10.1177\/1090820X14539973","article-title":"Internal and External Carotid Artery Embolism Following Facial Injection of Autologous Fat","volume":"34","author":"Wang","year":"2014","journal-title":"Aesthet. Surg. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/IOP.0000000000000160","article-title":"Effect of Autologous Fat Injection on Lower Eyelid Position","volume":"30","author":"Le","year":"2014","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1097\/GOX.0000000000000006","article-title":"Morcellized Omental Transfer for Severe HIV Facial Wasting","volume":"1","author":"Teplica","year":"2013","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/jamaophthalmol.2013.8204","article-title":"Iatrogenic Occlusion of the Ophthalmic Artery after Cosmetic Facial Filler Injections: A National Survey by the Korean Retina Society","volume":"132","author":"Park","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/j.jcjo.2013.08.002","article-title":"Periorbital Lipogranuloma after Cryopreserved Autologous Fat Injection at Forehead: Unexpected Complication of a Popular Cosmetic Procedure","volume":"48","author":"Choi","year":"2013","journal-title":"Can. J. Ophthalmol. J. Can. Ophtalmol."},{"key":"ref_56","first-page":"138","article-title":"Dystrophic Calcifications after Autologous Fat Injection on Face","volume":"16","author":"Kim","year":"2014","journal-title":"J. Cosmet. Laser Ther. Off. Publ. Eur. Soc. Laser Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1097\/SCS.0b013e31828f27ee","article-title":"Mixed Infection of an Atypical Mycobacterium and Aspergillus Following a Cryopreserved Fat Graft to a Face","volume":"24","author":"Kim","year":"2013","journal-title":"J. Craniofac. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/j.jaad.2013.02.018","article-title":"Autologous Fat Transfer-Induced Facial Nodule","volume":"69","author":"Brodell","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Paik, J.-S., Cho, W.-K., Park, G.-S., and Yang, S.-W. (2013). Eyelid-Associated Complications after Autogenous Fat Injection for Cosmetic Forehead Augmentation. BMC Ophthalmol., 13.","DOI":"10.1186\/1471-2415-13-32"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/SAP.0b013e31827eac42","article-title":"Autologous Fat Transfer in Aesthetic Facial Recontouring","volume":"70","author":"Gamboa","year":"2013","journal-title":"Ann. Plast. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kaminagakura, E., Rosa, J.A., Carvalho, Y.R., and Almeida, J.D. (2013). Undesirable Effect of Cosmetic Lip Augmentation with Autologous Fat Tissue. BMC Res. Notes, 6.","DOI":"10.1186\/1756-0500-6-79"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bjps.2012.11.038","article-title":"Complications of Fat Grafts Growth after Weight Gain: Report of a Severe Diplopia","volume":"66","author":"Duhoux","year":"2013","journal-title":"J. Plast. Reconstr. Aesthetic Surg. JPRAS"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1097\/IAE.0b013e31826a6897","article-title":"Ophthalmic Artery Occlusion Secondary to Fat Emboli after Cosmetic Nasal Injection of Autologous Fat","volume":"32","author":"Xing","year":"2012","journal-title":"Retina Phila. Pa"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/PRS.0b013e31824ecbb0","article-title":"An Analysis of the Experiences of 62 Patients with Moderate Complications after Full-Face Fat Injection for Augmentation","volume":"129","author":"Kim","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/SAP.0b013e31821ee386","article-title":"Autologous Fat Grafting for Correction of Unaesthetic Scars","volume":"69","author":"Guisantes","year":"2012","journal-title":"Ann. Plast. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s00266-011-9681-4","article-title":"Fat Grafting to the Nose: Personal Experience with 36 Patients","volume":"35","author":"Monreal","year":"2011","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jvir.2010.10.023","article-title":"Partial Recovery after Intraarterial Pharmacomechanical Thrombolysis in Ophthalmic Artery Occlusion Following Nasal Autologous Fat Injection","volume":"22","author":"Park","year":"2011","journal-title":"J. Vasc. Interv. Radiol. JVIR"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1099\/jmm.0.024554-0","article-title":"Mycobacterium Conceptionense Infection Complicating Face Rejuvenation with Fat Grafting","volume":"60","author":"Yang","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bjo.2010.180547","article-title":"Periorbital Lipogranuloma: A Previously Unknown Complication of Autologous Fat Injections for Facial Augmentation","volume":"95","author":"Sa","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref_70","first-page":"359","article-title":"Autologous Fat Transfer to the Cranio-Maxillofacial Region: Updates and Controversies","volume":"39","year":"2011","journal-title":"J. Cranio-Maxillo-Fac. Surg. Off. Publ. Eur. Assoc. Cranio-Maxillo-Fac. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/j.tripleo.2009.09.017","article-title":"Use of Autologous Fat Graft for Correction of Facial Asymmetry Stemming from Parry-Romberg Syndrome","volume":"109","author":"Avelar","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/PRS.0b013e3181af023a","article-title":"Influence of the Recipient Site on the Outcomes of Fat Grafting in Facial Reconstructive Surgery","volume":"124","author":"Mojallal","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/sj.bdj.2009.166","article-title":"Facial Atrophy Following Accidental Subcutaneous Extrusion of Sodium Hypochlorite","volume":"206","author":"Markose","year":"2009","journal-title":"Br. Dent. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00266-008-9287-7","article-title":"Minimally Invasive Combined Treatment for Parry-Romberg Syndrome","volume":"33","author":"Onesti","year":"2009","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_75","first-page":"1659","article-title":"Autologous Fat Transplantation for Depressed Linear Scleroderma-Induced Facial Atrophic Scars","volume":"34","author":"Roh","year":"2008","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/SCS.0b013e318176354a","article-title":"Lipostructure Technique in Romberg Syndrome","volume":"19","author":"Grimaldi","year":"2008","journal-title":"J. Craniofac. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00266-008-9223-x","article-title":"Use of Cell Fat Mixed with Platelet Gel in Progressive Hemifacial Atrophy","volume":"33","author":"Cervelli","year":"2009","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/SAP.0b013e318038fcb7","article-title":"Correction of Hemifacial Atrophy with Autologous Fat Transplantation","volume":"59","author":"Xie","year":"2007","journal-title":"Ann. Plast. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/01.sap.0000248110.59452.49","article-title":"Introduction of an Easy Technique for Purification and Injection of Autogenous Free Fat Parcels in Correcting of Facial Contour Deformities","volume":"58","author":"Hu","year":"2007","journal-title":"Ann. Plast. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jcms.2006.07.857","article-title":"Fat Microinfiltration Autografting for Facial Restructuring in HIV Patients","volume":"34","author":"Domergue","year":"2006","journal-title":"J. Cranio-Maxillo-Fac. Surg. Off. Publ. Eur. Assoc. Cranio-Maxillo-Fac. Surg."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1473-2130.2004.00060.x","article-title":"Fat Injections for Facial Rejuvenation: 17 Years Experience in 1720 Patients","volume":"2","year":"2003","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bjps.2005.12.047","article-title":"Treatment of Human Immunodeficiency Virus-Associated Facial Lipoatrophy with Lipofilling and Submalar Silicone Implants","volume":"59","author":"Mori","year":"2006","journal-title":"J. Plast. Reconstr. Aesthetic Surg. JPRAS"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"108S","DOI":"10.1097\/01.prs.0000234610.81672.e7","article-title":"Structural Fat Grafting: More than a Permanent Filler","volume":"118","author":"Coleman","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1086\/426686","article-title":"Facial Lipohypertrophy in HIV-Infected Subjects Who Underwent Autologous Fat Tissue Transplantation","volume":"40","author":"Guaraldi","year":"2005","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.asj.2004.08.006","article-title":"The Volumetric Face Lift","volume":"24","author":"Ellenbogen","year":"2004","journal-title":"Aesthet. Surg. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00001665-200405000-00027","article-title":"Augmentation by Autologous Adipose Tissue in Cleft Lip and Nose. Final Esthetic Touches in Clefts: Part I","volume":"15","author":"Duskova","year":"2004","journal-title":"J. Craniofac. Surg."},{"key":"ref_87","first-page":"1019","article-title":"Facial Volume Restoration with the Fat Autograft Muscle Injection Technique","volume":"29","author":"Butterwick","year":"2003","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00006534-199807000-00032","article-title":"Simultaneous Rhytidoplasty and Lipoinjection: A Comprehensive Aesthetic Surgical Strategy","volume":"102","author":"Guerrerosantos","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00002341-200205000-00015","article-title":"Fat Hypertrophy after Autologous Fat Transfer","volume":"18","author":"Miller","year":"2002","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-2008-1064474","article-title":"Improving the Aesthetic Aspect of Soft Tissue Defects on the Face Using Autologous Fat Transplantation","volume":"13","year":"1997","journal-title":"Facial Plast. Surg. FPS"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s002669900185","article-title":"Autologous Fat Injection for Soft Tissue Augmentation in the Face: A Safe Procedure?","volume":"22","author":"Feinendegen","year":"1998","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02390317","article-title":"Large Liponecrotic Pseudocyst Formation Following Cheek Augmentation by Fat Injection","volume":"20","author":"Lindenbaum","year":"1996","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1524-4725.1992.tb02795.x","article-title":"Autologous Fat Transplantation. Long-Term Follow-Up","volume":"18","author":"Pinski","year":"1992","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1010-5182(05)80292-6","article-title":"Clinical Evaluation of Techniques Used in the Surgical Treatment of Progressive Hemifacial Atrophy","volume":"22","author":"Roddi","year":"1994","journal-title":"J. Cranio-Maxillo-Fac. Surg. Off. Publ. Eur. Assoc. Cranio-Maxillo-Fac. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0002-9394(89)90823-4","article-title":"Sudden Unilateral Visual Loss after Autologous Fat Injection into the Glabellar Area","volume":"107","author":"Dreizen","year":"1989","journal-title":"Am. J. Ophthalmol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01570383","article-title":"Experience of Injected Fat Grafting","volume":"12","author":"Matsudo","year":"1988","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1524-4725.1988.tb03342.x","article-title":"Combined Scalp Reduction and Autologous Fat Implant Treatment of Localized Soft Tissue Defects","volume":"14","author":"Roenigk","year":"1988","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01575279","article-title":"Liposuction Fat Grafts in Face Wrinkles and Hemifacial Atrophy","volume":"10","author":"Chajchir","year":"1986","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1056\/NEJMicm1100804","article-title":"Images in Clinical Medicine. Blindness after Fat Injections","volume":"365","author":"Park","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1212\/WNL.61.8.1151","article-title":"Acute Fatal Stroke Immediately Following Autologous Fat Injection into the Face","volume":"61","author":"Yoon","year":"2003","journal-title":"Neurology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.STR.24.4.615","article-title":"Middle Cerebral Artery Embolism and Unilateral Visual Loss after Autologous Fat Injection into the Glabellar Area","volume":"24","author":"Egido","year":"1993","journal-title":"Stroke"},{"key":"ref_102","first-page":"679","article-title":"Sudden Unilateral Visual Loss after Autologous Fat Injection into the Nasolabial Fold","volume":"2","author":"Park","year":"2008","journal-title":"Clin. Ophthalmol. Auckl. NZ"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1136\/bjo.80.11.1026","article-title":"Sudden Unilateral Visual Loss and Brain Infarction after Autologous Fat Injection into Nasolabial Groove","volume":"80","author":"Lee","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3760\/cma.j.issn.0366-6999.20133254","article-title":"Fundus Artery Occlusion Caused by Cosmetic Facial Injections","volume":"127","author":"Chen","year":"2014","journal-title":"Chin. Med. J."},{"key":"ref_105","first-page":"485","article-title":"Sudden Visual Loss and Multiple Cerebral Infarction after Autologous Fat Injection into the Glabella","volume":"40","author":"Hong","year":"2014","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3340\/jkns.2012.51.5.312","article-title":"Magnetic Resonance Findings in Two Episodes of Repeated Cerebral Fat Embolisms in a Patient with Autologous Fat Injection into the Face","volume":"51","author":"Lee","year":"2012","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s004150050177","article-title":"Middle Cerebral Artery Occlusion AND Ocular Fat Embolism after Autologous Fat Injection in the Face","volume":"245","author":"Feinendegen","year":"1998","journal-title":"J. Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3341\/kjo.2011.25.5.358","article-title":"Ophthalmic Artery Obstruction and Cerebral Infarction Following Periocular Injection of Autologous Fat","volume":"25","author":"Lee","year":"2011","journal-title":"Korean J. Ophthalmol. KJO"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.wneu.2018.08.148","article-title":"Cerebral Fat Embolism as Complication of Facial Fat Graft: Retrospective Analysis of Clinical Characteristics, Treatment, and Prognosis","volume":"120","author":"Huo","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jns.2014.08.030","article-title":"Central Retinal Artery Occlusion with Concomitant Ipsilateral Cerebral Infarction after Cosmetic Facial Injections","volume":"346","author":"Hong","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"S487","DOI":"10.1097\/SAP.0000000000002873","article-title":"Adipose Grafting for Volume and Scar Release","volume":"86","author":"Le","year":"2021","journal-title":"Ann. Plast. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijscr.2021.01.006","article-title":"Lipofilling as an Aesthetic Restorative Technique for the Facial Hemiatrophy of Parry-Romberg Syndrome: An Analysis of 27 Cases","volume":"79","author":"Aloua","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/PRS.0000000000001364","article-title":"Deaths Caused by Gluteal Lipoinjection: What Are We Doing Wrong?","volume":"136","author":"Bayter","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/PRS.0000000000004219","article-title":"Critical Differences between Microscopic (MIFE) and Macroscopic (MAFE) Fat Embolism during Liposuction and Gluteal Lipoinjection","volume":"141","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_115","first-page":"622","article-title":"Adult Respiratory Distress Syndrome Due to Fat Embolism in the Postoperative Period Following Liposuction and Fat Grafting","volume":"34","author":"Costa","year":"2008","journal-title":"J. Bras. Pneumol. Publicacao Of. Soc. Bras. Pneumol. E Tisilogia"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00266-017-0805-3","article-title":"Ocular Complications Following Autologous Fat Injections into Facial Area: Case Report of a Recovery from Visual Loss After Ophthalmic Artery Occlusion and a Review of the Literature","volume":"41","author":"Szantyr","year":"2017","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e2091","DOI":"10.1097\/GOX.0000000000002091","article-title":"The Successful Mechanical Lipectomy Treatment of Cerebral Fat Embolism Following Autologous Fat Injection","volume":"7","author":"Zhou","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00266-020-01612-6","article-title":"Volume Retention After Facial Fat Grafting and Relevant Factors: A Systematic Review and Meta-Analysis","volume":"45","author":"Lv","year":"2021","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00266-018-1265-0","article-title":"Internal Carotid Artery Embolism After Autologous Fat Injection for Temporal Augmentation","volume":"43","author":"Liu","year":"2019","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/SCS.0000000000004625","article-title":"Autologous Fat Used for Facial Filling Can Lead to Massive Cerebral Infarction Through Middle Cerebral Artery or Facial Intracranial Branches","volume":"29","author":"Wang","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0036-1582233","article-title":"The Impact of Facial Lipofilling on Patient-Perceived Improvement in Facial Appearance and Quality of Life","volume":"32","author":"Tepavcevic","year":"2016","journal-title":"Facial Plast. Surg. 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