{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:26Z","timestamp":1787028626312,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACyT","doi-asserted-by":"publisher","award":["753044"],"award-info":[{"award-number":["753044"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACyT","doi-asserted-by":"publisher","award":["2192803055"],"award-info":[{"award-number":["2192803055"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidad Aut\u00f3moma Metropolitana","award":["753044"],"award-info":[{"award-number":["753044"]}]},{"name":"Universidad Aut\u00f3moma Metropolitana","award":["2192803055"],"award-info":[{"award-number":["2192803055"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this work was to obtain insights of the participation of the autonomic nervous system in different stages of calcific aortic valve disease (CAVD) by heart rate variability (HRV) analysis. Studying subjects with no valve impairments and CAVD patients, we also sought to quantify the independent contribution or explanatory capacity of the aortic valve echocardiographic parameters involved in the HRV changes caused by active standing using hierarchical partitioning models to consider other variables or potential confounders. We detected smaller adjustments of the cardiac autonomic response at active standing caused specifically by the aortic valve deterioration. The highest association (i.e., the highest percentage of independent exploratory capacity) was found between the aortic valve area and the active standing changes in the short-term HRV scaling exponent \u03b11 (4.591%). The valve\u2019s maximum pressure gradient echocardiographic parameter was present in most models assessed (in six out of eight models of HRV indices that included a valve parameter as an independent variable). Overall, our study provides insights with a wider perspective to explore and consider CAVD as a neurocardiovascular pathology. This pathology involves autonomic-driven compensatory mechanisms that seem generated by the aortic valve deterioration.<\/jats:p>","DOI":"10.3390\/jcm11164771","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T23:44:25Z","timestamp":1660693465000},"page":"4771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology"],"prefix":"10.3390","volume":"11","author":[{"given":"Jimena","family":"Rodr\u00edguez-Carb\u00f3","sequence":"first","affiliation":[{"name":"Posgrado en Ingenier\u00eda Biom\u00e9dica, Divisi\u00f3n de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma Metropolitana, Unidad Iztapalapa, Mexico City 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Torres-Arellano","sequence":"additional","affiliation":[{"name":"Departamento de Instrumentaci\u00f3n Electromec\u00e1nica, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nydia","family":"\u00c1vila-Vanzzini","sequence":"additional","affiliation":[{"name":"Departamento de Consulta Externa, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashidi","family":"Springall","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-3675","authenticated-orcid":false,"given":"Rafael","family":"Bojalil","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Unidad Xochimilco, Mexico City 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Infante","sequence":"additional","affiliation":[{"name":"Departamento de Instrumentaci\u00f3n Electromec\u00e1nica, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-7751","authenticated-orcid":false,"given":"Claudia","family":"Lerma","sequence":"additional","affiliation":[{"name":"Departamento de Instrumentaci\u00f3n Electromec\u00e1nica, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda El\u00e9ctrica, Divisi\u00f3n de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma Metropolitana, Unidad Iztapalapa, Mexico City 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","unstructured":"Willis, M.S., Homeister, J.W., and Stone, J.R. 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