{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:09:09Z","timestamp":1788908949964,"version":"build-2803163510"},"reference-count":32,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Nerve compression syndromes of the upper extremity are a common cause of neuropathic pain and functional impairment. Recently, platelet-rich plasma (PRP) infiltrations have emerged as an effective biological approach to the treatment of this type of injury. The objectives of this retrospective observational study were to assess clinical improvement in patients with median and ulnar nerve entrapment syndrome after undergoing biologically-assisted nerve release surgery with plasma-rich-in-growth-factors (PRGF) technology. Methods: Participants (n = 39) with moderate-to-severe nerve compression syndrome of the upper limb diagnosed by both electromyography and clinical examination, and who were treated with PRGF, were identified from the center\u2019s medical records. The evaluation was based on patient-reported outcomes. Pre- and post-treatment differences in the Visual analog scale (VAS), the Boston carpal tunnel questionnaire (BCTQ), and the Quick-DASH score were assessed. Results: Three study groups were conducted: patients with carpal tunnel syndrome (n = 16), with recurrent carpal tunnel syndrome (n = 8), and with ulnar nerve entrapment (n = 15). The median follow-up was 12 months (interquartile range (IQR), 9\u201316). In comparison to pre-treatment values, all three study groups obtained statistically significant improvements for the three analyzed scales at the end of the follow-up, with p &lt; 0.001 for all scales in the carpal tunnel syndrome and ulnar nerve entrapment groups and p &lt; 0.01 for all scales in the recurrent carpal tunnel syndrome group. There were no serious adverse effects in the analyzed patients. Conclusion: PRGF-assisted open surgical nerve release treatment (intraneural and perineural liquid PRGF infiltrations and nerve wrapping with PRGF membrane) exerts long-term beneficial effects on pain reduction and functional improvement in the nerve and nerve\u2013muscle unit in patients with upper extremity compression syndromes.<\/jats:p>","DOI":"10.3390\/jcm11164789","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T23:44:25Z","timestamp":1660693465000},"page":"4789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Effectiveness of Plasma Rich in Growth Factors (PRGF) in the Treatment of Nerve Compression Syndromes of the Upper Extremity: A Retrospective Observational Clinical Study"],"prefix":"10.3390","volume":"11","author":[{"given":"V\u00edctor","family":"Gal\u00e1n","sequence":"first","affiliation":[{"name":"Hand, Wrist and Microsurgery Unit, Cl\u00ednica Indautxu, 48010 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"I\u00f1igo-Dendariarena","sequence":"additional","affiliation":[{"name":"Hand, Wrist and Microsurgery Unit, Cl\u00ednica Indautxu, 48010 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Gal\u00e1n","sequence":"additional","affiliation":[{"name":"School of Medicine, European University, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-7206","authenticated-orcid":false,"given":"Roberto","family":"Prado","sequence":"additional","affiliation":[{"name":"BTI-Biotechnology Institute I MAS D, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV\/EHU-Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"},{"name":"Eduardo Anitua Foundation for Biomedical Research, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Padilla","sequence":"additional","affiliation":[{"name":"BTI-Biotechnology Institute I MAS D, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV\/EHU-Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"},{"name":"Eduardo Anitua Foundation for Biomedical Research, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-5303","authenticated-orcid":false,"given":"Eduardo","family":"Anitua","sequence":"additional","affiliation":[{"name":"BTI-Biotechnology Institute I MAS D, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV\/EHU-Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"},{"name":"Eduardo Anitua Foundation for Biomedical Research, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1056\/NEJMcp013018","article-title":"Clinical practice. 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