{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:00Z","timestamp":1790030040072,"version":"4.0.1"},"reference-count":84,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Psoriasis is a common chronic inflammatory skin disease of the interleukin (IL)-23\/IL-17 axis. The severity of psoriasis has been reported as higher in men than in women. The immunoregulatory role of female sex hormones has been proposed to be one of the factors responsible for sex differences. Among female sex hormones, estrogens have been suggested to be significantly involved in the development of psoriasis by various epidemiological and in vitro studies. For example, the severity of psoriasis is inversely correlated with serum estrogen levels. In vitro, estrogens suppress the production of psoriasis-related cytokines such as IL-1\u03b2 and IL-23 from neutrophils and dendritic cells, respectively. Furthermore, a recent study using a mouse psoriasis model indicated the inhibitory role of estrogens in psoriatic dermatitis by suppressing IL-1\u03b2 production from neutrophils and macrophages. Understanding the role and molecular mechanisms of female sex hormones in psoriasis may lead to better control of the disease.<\/jats:p>","DOI":"10.3390\/jcm11164890","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T23:51:01Z","timestamp":1661125861000},"page":"4890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Regulatory Roles of Estrogens in Psoriasis"],"prefix":"10.3390","volume":"11","author":[{"given":"Akimasa","family":"Adachi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, Japan"},{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan"},{"name":"Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: A systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 Family of Cytokines in Health and Disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal Role of Dermal IL-17-Producing \u03b3\u03b4 T Cells in Skin Inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jid.2018.07.025","article-title":"A Critical Role of the IL-1\u03b2\u2013IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis","volume":"139","author":"Cai","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","first-page":"1","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2004.10.011","article-title":"Regulatory roles of sex hormones in cutaneous biology and immunology","volume":"38","author":"Kanda","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/mi.2017.35","article-title":"Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites","volume":"10","author":"Hall","year":"2017","journal-title":"Mucosal Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/jc.2013-2905","article-title":"Measurement of estradiol-challenges ahead","volume":"99","author":"Stanczyk","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogen receptors regulate innate immune cells and signaling pathways","volume":"294","author":"Kovats","year":"2015","journal-title":"Cell. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/MCB.25.8.2957-2968.2005","article-title":"17\u03b2-Estradiol Inhibits Inflammatory Gene Expression by Controlling NF-\u03baB Intracellular Localization","volume":"25","author":"Ghisletti","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/me.2004-0486","article-title":"Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes","volume":"19","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"39762","DOI":"10.1074\/jbc.M303541200","article-title":"Sp1 and Sp3 transcription factors mediate interleukin-1\u03b2 down-regulation of human type II collagen gene expression in articular chondrocytes","volume":"278","author":"Chadjichristos","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/emmm.202012409","article-title":"Psoriatic skin inflammation is promoted by c-Jun\/AP-1-dependent CCL2 and IL-23 expression in dendritic cells","volume":"13","author":"Novoszel","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33190","DOI":"10.1074\/jbc.274.47.33190","article-title":"A Sp1 binding site of the tumor necrosis factor \u03b1 promoter functions as a nitric oxide response element","volume":"274","author":"Wang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.bbagrm.2015.06.002","article-title":"C\/EBP\u03b2 is a transcriptional key regulator of IL-36\u03b1 in murine macrophages","volume":"1849","author":"Nerlich","year":"2015","journal-title":"Biochim. Biophys. Acta\u2014Gene Regul. Mech."},{"key":"ref_20","first-page":"1","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"579420","DOI":"10.3389\/fendo.2020.579420","article-title":"G Protein-Coupled Estrogen Receptor in Immune Cells and Its Role in Immune-Related Diseases","volume":"11","author":"Notas","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s40257-017-0274-0","article-title":"Severity of Psoriasis Differs Between Men and Women: A Study of the Clinical Outcome Measure Psoriasis Area and Severity Index (PASI) in 5438 Swedish Register Patients","volume":"18","author":"Eriksson","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1346-8138.2011.01209.x","article-title":"Prevalence of dermatological disorders in Japan: A nationwide, cross-sectional, seasonal, multicenter, hospital-based study","volume":"38","author":"Furue","year":"2011","journal-title":"J. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1346-8138.2009.00721.x","article-title":"Analysis of psoriatic patients registered in Asahikawa Medical College Hospital from 1983 to 2007","volume":"36","author":"Takahashi","year":"2009","journal-title":"J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0923-1811(02)00142-1","article-title":"A survey of psoriasis patients in Japan from 1982 to 2001","volume":"31","author":"Kawada","year":"2003","journal-title":"J. Dermatol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jdin.2020.06.002","article-title":"Clinical and epidemiologic features of psoriasis patients in an Egyptian medical center","volume":"1","author":"Mashaly","year":"2020","journal-title":"JAAD Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5021\/ad.2017.29.6.761","article-title":"Prevalence of psoriasis in Korea: A population-based epidemiological study using the Korean national health insurance database","volume":"29","author":"Lee","year":"2017","journal-title":"Ann. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/1346-8138.12224","article-title":"Il Clinical study on psoriasis patients for past 30 years (1982-2012) in Seoul National University Hospital Psoriasis Clinic","volume":"40","author":"Na","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2011.03.002","article-title":"Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan","volume":"63","author":"Tsai","year":"2011","journal-title":"J. Dermatol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/1346-8138.14321","article-title":"Relationship between environmental factors, age of onset and familial history in Japanese patients with psoriasis","volume":"45","author":"Bayaraa","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000251595","article-title":"The natural history of psoriasis in 5600 patients","volume":"148","author":"Farber","year":"1974","journal-title":"Dermatologica"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamadermatol.2021.2007","article-title":"Psoriasis Prevalence in Adults in the United States","volume":"157","author":"Armstrong","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0190-9622(85)70188-0","article-title":"Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris","volume":"13","author":"Henseler","year":"1985","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e010","DOI":"10.1097\/JW9.0000000000000010","article-title":"The impact of gender and sex in psoriasis: What to be aware of when treating women with psoriasis","volume":"8","author":"Guillet","year":"2022","journal-title":"Int. J. Women\u2019s Dermatol."},{"key":"ref_36","first-page":"369","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/archderm.1979.04010100035015","article-title":"Generalized Pustular Psoriasis","volume":"115","author":"Murphy","year":"1979","journal-title":"Arch. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1001\/archderm.141.5.601","article-title":"Hormonal effect on psoriasis in pregnancy and post partum","volume":"141","author":"Murase","year":"2005","journal-title":"Arch. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1046\/j.1365-4362.2003.01760.x","article-title":"Clinical course of psoriasis during pregnancy","volume":"42","author":"Raychaudhuri","year":"2003","journal-title":"Int. J. Dermatol."},{"key":"ref_40","first-page":"257","article-title":"Hormonal Influences on Women with Psoriasis","volume":"61","author":"Mowad","year":"1998","journal-title":"Cutis"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1346-8138.1998.tb02357.x","article-title":"Il Factors influencing psoriasis: An analysis based upon the extent of involvement and clinical type","volume":"25","author":"Park","year":"1998","journal-title":"J. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-4362.1996.tb01632.x","article-title":"Psoriasis and pregnancy: Hormone and immune system interaction","volume":"35","author":"Boyd","year":"1996","journal-title":"Int. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/rheumatology\/28.1.50","article-title":"The effect of pregnancy on the onset of psoriatic arthritis","volume":"28","author":"McHugh","year":"1989","journal-title":"Br. J. Rheumatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/1346-8138.12803","article-title":"Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index","volume":"42","author":"Cemil","year":"2015","journal-title":"J. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archderm.1972.01620050003001","article-title":"Metabolic and Ultrastructural Studies in a Patient With Pustular Psoriasis (von Zumbusch)","volume":"105","author":"Braverman","year":"1972","journal-title":"Arch. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/jcem-29-5-650","article-title":"Enhancement of the anti-inflammatory action of hydrocortisone by estrogen","volume":"29","author":"Spangler","year":"1969","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0190-9622(99)70356-7","article-title":"Tamoxifen-induced remission of psoriasis","volume":"41","author":"Boyd","year":"1999","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Smolinska, E., Moskot, M., Jak\u00f3bkiewicz-Banecka, J., Wegrzyn, G., Banecki, B., Szczerkowska-Dobosz, A., Purzycka-Bohdan, D., and Gabig-Ciminska, M. (2018). Molecular action of isoflavone genistein in the human epithelial cell line HaCaT. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192297"},{"key":"ref_49","first-page":"1","article-title":"Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations","volume":"11","author":"Moskot","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_51","first-page":"1058","article-title":"17\u03b2-Estradiol Inhibits MCP-1 Production in Human Keratinocytes","volume":"120","author":"Kanda","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1046\/j.1523-1747.2003.12067.x","article-title":"17\u03b2-estradiol inhibits the production of RANTES in human keratinocytes","volume":"120","author":"Kanda","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_53","first-page":"1","article-title":"Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.intimp.2019.01.054","article-title":"Genistein suppresses psoriasis-related inflammation through a STAT3\u2013NF-\u03baB-dependent mechanism in keratinocytes","volume":"69","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/mjd.2000.103264","article-title":"Rapid improvement of psoriasis vulgaris during drug-induced agranulocytosis","volume":"43","author":"Toichi","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jaad.2012.09.037","article-title":"Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis","volume":"68","author":"Ikeda","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.4049\/jimmunol.1302959","article-title":"Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis","volume":"192","author":"Sumida","year":"2014","journal-title":"J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"108294","DOI":"10.1016\/j.clim.2019.108294","article-title":"Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis","volume":"210","author":"Han","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jdermsci.2016.03.004","article-title":"CX3CR1 deficiency attenuates imiquimod-induced psoriasis-like skin inflammation with decreased M1 macrophages","volume":"82","author":"Morimura","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"121175","DOI":"10.1172\/jci.insight.121175","article-title":"Epithelial TRAF6 drives IL-17\u2013mediated psoriatic inflammation","volume":"3","author":"Matsumoto","year":"2018","journal-title":"JCI Insight"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4049\/jimmunol.167.1.542","article-title":"Estrogen Treatment Down-Regulates TNF-\u03b1 Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice","volume":"167","author":"Ito","year":"2001","journal-title":"J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcb.10607","article-title":"Estrogen regulates cytokine production and apoptosis in PMA-differentiated, macrophage-like U937 cells","volume":"90","author":"Carruba","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.fertnstert.2004.05.072","article-title":"17\u03b2-Estradiol and progesterone do not influence the production of cytokines from lipopolysaccharide-stimulated monocytes in humans","volume":"82","author":"Bouman","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S8756-3282(01)00468-9","article-title":"The effect of 17\u03b2-estradiol on production of cytokines in cultures of peripheral blood","volume":"29","author":"Rogers","year":"2001","journal-title":"Bone"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/art.1780270604","article-title":"Female hormones reduce neutrophil responsiveness in vitro","volume":"27","author":"Buyon","year":"1984","journal-title":"Arthritis Rheum."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2003-02-0649","article-title":"Sex-specific alterations in neutrophil apoptosis: The role of estradiol and progesterone","volume":"102","author":"Molloy","year":"2003","journal-title":"Blood"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1189\/jlb.1110645","article-title":"Estradiol impairs the Th17 immune response against Candida albicans","volume":"91","author":"Relloso","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_68","first-page":"1","article-title":"Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway","volume":"12","author":"Anipindi","year":"2016","journal-title":"PLoS Pathog."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1182\/blood-2003-10-3380","article-title":"17\u03b2-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells","volume":"104","author":"Bengtsson","year":"2004","journal-title":"Blood"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.4049\/jimmunol.1400806","article-title":"Estradiol Inhibits Th17 Cell Differentiation through Inhibition of ROR\u03b3T Transcription by Recruiting the ER\u03b1\/REA Complex to Estrogen Response Elements of the ROR\u03b3T Promoter","volume":"194","author":"Chen","year":"2015","journal-title":"J. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmi008","article-title":"Sex hormones and the immune response in humans","volume":"11","author":"Bouman","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.4049\/jimmunol.1101578","article-title":"Estrogen Receptor \u03b1 Signaling in T Lymphocytes Is Required for Estradiol-Mediated Inhibition of Th1 and Th17 Cell Differentiation and Protection against Experimental Autoimmune Encephalomyelitis","volume":"187","author":"Laffont","year":"2011","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/jbmr.5650050912","article-title":"Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women","volume":"5","author":"Ralston","year":"1990","journal-title":"J. Bone Miner. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4049\/jimmunol.158.1.446","article-title":"Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects","volume":"158","author":"Gilmore","year":"1997","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00635","article-title":"The immune system is a natural target for estrogen action: Opposing effects of estrogen in two prototypical autoimmune diseases","volume":"6","author":"Khan","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/1547691X.2016.1223768","article-title":"Medium-dose estrogen ameliorates experimental autoimmune encephalomyelitis in ovariectomized mice","volume":"13","author":"Haghmorad","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/1346-8138.15913","article-title":"Pathophysiology of psoriasis: A review","volume":"48","author":"Yamanaka","year":"2021","journal-title":"J. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijwd.2015.03.001","article-title":"The immunologic effects of estrogen on psoriasis: A comprehensive review","volume":"1","author":"Danesh","year":"2015","journal-title":"Int. J. Women\u2019s Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/jat.3988","article-title":"Estrogen receptor \u03b1 activation aggravates imiquimod-induced psoriasis-like dermatitis in mice by enhancing dendritic cell interleukin-23 secretion","volume":"40","author":"Iwano","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Adachi, A., Honda, T., Egawa, G., Kanameishi, S., Takimoto, R., Miyake, T., Hossain, M.R., Komine, M., Ohtsuki, M., and Gunzer, M. (2022). Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions. J. Allergy Clin. Immunol.","DOI":"10.1016\/j.jaci.2022.03.028"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0015-0282(01)01971-9","article-title":"The immune response during the luteal phase of the ovarian cycle: Increasing sensitivity of human monocytes to endotoxin","volume":"76","author":"Bouman","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1126\/science.3871966","article-title":"Increased plasma interleukin-1 activity in women after ovulation","volume":"227","author":"Cannon","year":"1984","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0301-2115(99)00003-2","article-title":"Variations in peripheral blood levels of immunoreactive tumor necrosis factor \u03b1 (TNF\u03b1) throughout the menstrual cycle and secretion of TNF\u03b1 from the human corpus luteum","volume":"83","author":"Jasper","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/jama.1967.03130130035009","article-title":"Generalized Pustular Psoriasis Induced by Potassium Iodide","volume":"201","author":"Shelley","year":"1967","journal-title":"Jama"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/16\/4890\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:46Z","timestamp":1760141566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/16\/4890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,20]]},"references-count":84,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jcm11164890"],"URL":"https:\/\/doi.org\/10.3390\/jcm11164890","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,20]]}}}