{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:51:00Z","timestamp":1789555860140,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the support of the Erasmus + Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"the support of the Erasmus + Programme of the European Union","award":["270-2017-294"],"award-info":[{"award-number":["270-2017-294"]}]},{"name":"the support of the Erasmus + Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"Secretar\u00eda Nacional de Ciencia y Tecnolog\u00eda de Panam\u00e1 (SENACYT)","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"Secretar\u00eda Nacional de Ciencia y Tecnolog\u00eda de Panam\u00e1 (SENACYT)","award":["270-2017-294"],"award-info":[{"award-number":["270-2017-294"]}]},{"name":"Secretar\u00eda Nacional de Ciencia y Tecnolog\u00eda de Panam\u00e1 (SENACYT)","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"Instituto Nacional para la formaci\u00f3n y aprovechamiento de Recursos Humanos de Panam\u00e1 (IFARHU)","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"Instituto Nacional para la formaci\u00f3n y aprovechamiento de Recursos Humanos de Panam\u00e1 (IFARHU)","award":["270-2017-294"],"award-info":[{"award-number":["270-2017-294"]}]},{"name":"Instituto Nacional para la formaci\u00f3n y aprovechamiento de Recursos Humanos de Panam\u00e1 (IFARHU)","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"APC was funded by the Erasmus + Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]},{"name":"APC was funded by the Erasmus + Programme of the European Union","award":["270-2017-294"],"award-info":[{"award-number":["270-2017-294"]}]},{"name":"APC was funded by the Erasmus + Programme of the European Union","award":["2013-0040"],"award-info":[{"award-number":["2013-0040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM\u00ae version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM\u00ae in predicting NRM was analyzed by matching quantitative ultrasound analysis and clinical outcomes. This study included 166 images. Neonatal respiratory morbidity occurred in 12.7% of cases, and it was predicted by quantusFLM\u00ae analysis with an overall sensitivity of 42.9%, specificity of 95.9%, positive predictive value of 60%, and negative predictive value of 92.1%. The accuracy was 89.2%, with a positive likelihood ratio of 10.4, and a negative likelihood ratio of 0.6. The results of this study demonstrate the good prediction capability of NRM in twin pregnancies using a non-invasive lung texture analysis software. The test showed an overall good performance with high specificity, negative predictive value, and accuracy.<\/jats:p>","DOI":"10.3390\/jcm11164895","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T23:51:01Z","timestamp":1661125861000},"page":"4895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-126X","authenticated-orcid":false,"given":"Ana L.","family":"Moreno-Espinosa","sequence":"first","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Department of Obstetrics and Gynecology, Hospital Santo Tom\u00e1s, Universidad de Panam\u00e1, Panama City 07096, Panama"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-4846","authenticated-orcid":false,"given":"Ameth","family":"Hawkins-Villarreal","sequence":"additional","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Department of Obstetrics and Gynecology, Hospital Santo Tom\u00e1s, Universidad de Panam\u00e1, Panama City 07096, Panama"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-5130","authenticated-orcid":false,"given":"David","family":"Coronado-Gutierrez","sequence":"additional","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Transmural Biotech SL, 08021 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier P.","family":"Burgos-Artizzu","sequence":"additional","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Transmural Biotech SL, 08021 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3857","authenticated-orcid":false,"given":"Raigam J.","family":"Mart\u00ednez-Portilla","sequence":"additional","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"},{"name":"Clinical Research Branch, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Pe\u00f1a-Ramirez","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad del Valle, Cali 760032, Colombia"},{"name":"Department of Obstetrics and Gynecology, Hospital Universitario del Valle Evaristo Garc\u00eda E.S.E., Cali 760043, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8150-6457","authenticated-orcid":false,"given":"Dahiana M.","family":"Gallo","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad del Valle, Cali 760032, Colombia"},{"name":"Department of Obstetrics and Gynecology, Hospital Universitario del Valle Evaristo Garc\u00eda E.S.E., Cali 760043, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-9074","authenticated-orcid":false,"given":"Stefan R.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences Lund, Lund University, 221 00 Lund, Sweden"},{"name":"Sk\u00e5ne University Hospital, 214 28 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratac\u00f2s","sequence":"additional","affiliation":[{"name":"BCNatal-Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"Centre for Biomedical 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