{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:27:45Z","timestamp":1766748465924,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Primary EBV-positive mucocutaneous ulcer (EBVMCU) is a rare and indolent disorder occurring in the oropharynx, skin, and gastrointestinal tract, with remission after removal of the immunosuppressive causes. We present a 69-year-old woman with heartburn, regurgitation of gastric acid, enlarged lymph nodes, and parotid glands. The endoscopic examination showed a circumscribed ulcer in the lower esophagus. A biopsy pathology indicated an esophageal EBV-associated lymphoproliferative disorder and a parotid gland\/lymph node indolent B-cell lymphoma. Interestingly, the patient did not undergo any treatment, but the endoscopic ulcer improved significantly after more than 2 months. The last pathology showed EBV negativity, and EBVMCU was considered in combination with clinical and endoscopic manifestations. We followed up with the patient at 6 months, and the symptoms of acid reflux and heartburn had disappeared. Our case demonstrates that EBVMCU may occur in the esophagus with spontaneous regression.<\/jats:p>","DOI":"10.3390\/jcm11164915","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T23:51:01Z","timestamp":1661125861000},"page":"4915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Epstein\u2013Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-8452","authenticated-orcid":false,"given":"Chunping","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Geriatric, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Nong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-3661","authenticated-orcid":false,"given":"Yunlong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric, Peking University First Hospital, Peking University, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1038\/s41379-020-0599-8","article-title":"Clinicopathological analysis of 34 Japanese patients with EBV-positive mucocutaneous ulcer","volume":"33","author":"Ikeda","year":"2020","journal-title":"Mod. 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