{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:29:04Z","timestamp":1790947744221,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Suppurative portal vein thrombosis (pylephlebitis) is an uncommon condition usually associated with an intra-abdominal infection or inflammatory process. In this study, we aimed to synthesize data on previously published cases according to the PRISMA guidelines. A total of 103 patients were included. Patients were more commonly male (71.8%) and had a mean age of 49 years. The most common infection associated with pylephlebitis was diverticulitis (n = 29, 28.2%), and Escherichia coli was the most isolated pathogen (n = 21, 20.4%). Blood cultures were positive in 64 cases (62.1%). The most common site of thrombosis was the main portal vein (PV) in 59 patients (57.3%), followed by the superior mesenteric vein (SMV) in 40 patients (38.8%) and the right branch of the PV in 30 patients (29.1%). Sepsis developed in 60 patients (58.3%). The mortality rate in our review was 8.7%, and independent risk factors for mortality were the presence of pertinent comorbidities (OR 5.5, p = 0.02), positive blood cultures (OR 2.2, p = 0.02), and sepsis (OR 17.2, p = 0.049).<\/jats:p>","DOI":"10.3390\/jcm11174992","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:04:32Z","timestamp":1661479472000},"page":"4992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Suppurative Thrombosis of the Portal Vein (Pylephlebits): A Systematic Review of Literature"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-3951","authenticated-orcid":false,"given":"Dorde","family":"Jevtic","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Department of Internal Medicine, Elmhurst Hospital Center, New York, NY 11373, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Gavrancic","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Mayo Clinic, Jacksonville, FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-1141","authenticated-orcid":false,"given":"Ivana","family":"Pantic","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Nordin","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA"},{"name":"Department of Family Medicine, Mayo Clinic Health System, Eau Claire, WI 54701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Nordstrom","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA"},{"name":"Department of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI 54702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-9541","authenticated-orcid":false,"given":"Marina","family":"Antic","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA"},{"name":"Department of Family Medicine, Mayo Clinic Health System, Eau Claire, WI 54701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-4026","authenticated-orcid":false,"given":"Nikola","family":"Pantic","sequence":"additional","affiliation":[{"name":"Clinic of Hematology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-5481","authenticated-orcid":false,"given":"Marija","family":"Kaljevic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Connecticut, Farmington, CT 06269, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-2539","authenticated-orcid":false,"given":"Bojan","family":"Joksimovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Fo\u010da, University of East Sarajevo, 71123 Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Petcu","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA"},{"name":"Department of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI 54702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen","family":"Jecmenica","sequence":"additional","affiliation":[{"name":"Oceana Gastroenterology Associated, Corona, CA 92881, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Milovanovic","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA"},{"name":"Department of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI 54702, 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