{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:15:11Z","timestamp":1784945711757,"version":"3.55.0"},"reference-count":194,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients with \u201cpost-COVID\u201d syndrome manifest with a variety of signs and symptoms that continue\/develop after acute COVID-19. Among the most common are gastrointestinal (GI) and mental symptoms. The reason for symptom occurrence lies in the SARS-CoV-2 capability of binding to exact receptors, among other angiotensin converting enzyme 2 (ACE2) receptors in gastrointestinal lining and neuropilin-1 (NRP-1) in the nervous system, which leads to loss of gastrointestinal and blood-brain barriers integrity and function. The data are mounting that SARS-CoV-2 can trigger systemic inflammation and lead to disruption of gut-brain axis (GBA) and the development of disorders of gut brain interaction (DGBIs). Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are the most common DGBIs syndromes. On the other hand, emotional disorders have also been demonstrated as DGBIs. Currently, there are no official recommendations or recommended procedures for the use of probiotics in patients with COVID-19. However, it can be assumed that many doctors, pharmacists, and patients will want to use a probiotic in the treatment of this disease. In such cases, strains with documented activity should be used. There is a constant need to plan and conduct new trials on the role of probiotics and verify their clinical efficacy for counteracting the negative consequences of COVID-19 pandemic. Quality control is another important but often neglected aspect in trials utilizing probiotics in various clinical entities. It determines the safety and efficacy of probiotics, which is of utmost importance in patients with post-acute COVID-19 syndrome.<\/jats:p>","DOI":"10.3390\/jcm11175155","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:50:51Z","timestamp":1661997051000},"page":"5155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Probiotics in the Management of Mental and Gastrointestinal Post-COVID Symptomes"],"prefix":"10.3390","volume":"11","author":[{"given":"Igor","family":"\u0141oniewski","sequence":"first","affiliation":[{"name":"Department of Biochemical Science, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3430-9079","authenticated-orcid":false,"given":"Karolina","family":"Skonieczna-\u017bydecka","sequence":"additional","affiliation":[{"name":"Department of Biochemical Science, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-1767","authenticated-orcid":false,"given":"Joanna","family":"So\u0142ek-Pastuszka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-5967","authenticated-orcid":false,"given":"Wojciech","family":"Marlicz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","unstructured":"(2022, August 13). Coronavirus COVID-19 (2019-NCoV). Available online: https:\/\/www.arcgis.com\/apps\/dashboards\/bda7594740fd40299423467b48e9ecf6."},{"key":"ref_2","unstructured":"Cascella, M., Rajnik, M., Aleem, A., Dulebohn, S.C., and Di Napoli, R. (2022). Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5114\/ait.2020.93867","article-title":"COVID-19: Gastrointestinal Symptoms and Potential Sources of SARS-CoV-2 Transmission","volume":"52","author":"Kotfis","year":"2020","journal-title":"Anaesthesiol. Intensive Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kukla, M., Skonieczna-\u017bydecka, K., Kotfis, K., Maciejewska, D., \u0141oniewski, I., Lara, L.F., Pazgan-Simon, M., Stachowska, E., Kaczmarczyk, M., and Koulaouzidis, A. (2020). COVID-19, MERS and SARS with Concomitant Liver Injury\u2014Systematic Review of the Existing Literature. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051420"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S1473-3099(20)30314-5","article-title":"Investigation of a COVID-19 Outbreak in Germany Resulting from a Single Travel-Associated Primary Case: A Case Series","volume":"20","author":"Buchholz","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10735-020-09915-3","article-title":"COVID-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms","volume":"51","author":"Mokhtari","year":"2020","journal-title":"J. Mol. Histol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e0380121","DOI":"10.1128\/mbio.03801-21","article-title":"Nutritional Modulation of Gut Microbiota Alleviates Severe Gastrointestinal Symptoms in a Patient with Post-Acute COVID-19 Syndrome","volume":"13","author":"Wang","year":"2022","journal-title":"mBio"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/19490976.2018.1546521","article-title":"Triclosan, a Common Antimicrobial Ingredient, on Gut Microbiota and Gut Health","volume":"10","author":"Sanidad","year":"2018","journal-title":"Gut Microbes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.scitotenv.2017.10.312","article-title":"Antibiotics and Common Antibacterial Biocides Stimulate Horizontal Transfer of Resistance at Low Concentrations","volume":"616\u2013617","author":"Jutkina","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s40200-020-00579-0","article-title":"The Most Important Challenges Ahead of Microbiome Pattern in the Post Era of the COVID-19 Pandemic","volume":"19","author":"Ejtahed","year":"2020","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.fsi.2018.11.007","article-title":"Dietary Lactobacillus Plantarum ST-III Alleviates the Toxic Effects of Triclosan on Zebrafish (Danio Rerio) via Gut Microbiota Modulation","volume":"84","author":"Zang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_12","unstructured":"Woodruff, M.C., Ramonell, R.P., Cashman, K.S., Nguyen, D.C., Ley, A.M., Kyu, S., Saini, A., Haddad, N., Chen, W., and Howell, J.C. (2020). Critically Ill SARS-CoV-2 Patients Display Lupus-like Hallmarks of Extrafollicular B Cell Activation. MedRxiv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.2337\/dc20-0576","article-title":"Obesity and COVID-19 Severity in a Designated Hospital in Shenzhen, China","volume":"43","author":"Cai","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S2213-2600(20)30116-8","article-title":"Are Patients with Hypertension and Diabetes Mellitus at Increased Risk for COVID-19 Infection?","volume":"8","author":"Fang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154217","DOI":"10.1016\/j.metabol.2020.154217","article-title":"Commentary: COVID-19 in Patients with Diabetes","volume":"107","author":"Hill","year":"2020","journal-title":"Metabolism"},{"key":"ref_16","first-page":"1820","article-title":"Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients","volume":"12","author":"Marques","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ward, D., Bhattarai, S., Rojas-Correa, M., Purkayastha, A., Holler, D., Qu, M.D., Mitchell, W., Yang, J., Fountain, S., and Zeamer, A. (2021). The Intestinal and Oral Microbiomes Are Robust Predictors of COVID-19 Severity the Main Predictor of COVID-19-Related Fatality [Preprint]. Univ. Mass. Med. Sch. Fac. Publ.","DOI":"10.1101\/2021.01.05.20249061"},{"key":"ref_18","first-page":"2930","article-title":"Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Altered Gut Microbiota","volume":"12","author":"Li","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.dsx.2020.12.040","article-title":"Potential Beneficial Role of Probiotics on the Outcome of COVID-19 Patients: An Evolving Perspective","volume":"15","author":"Santacroce","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41591-021-01283-z","article-title":"Post-Acute COVID-19 Syndrome","volume":"27","author":"Nalbandian","year":"2021","journal-title":"Nat. Med."},{"key":"ref_21","unstructured":"Komaroff, A.L. (2022, April 25). The Tragedy of Long COVID. Available online: https:\/\/www.health.harvard.edu\/blog\/the-tragedy-of-the-post-covid-long-haulers-202010152479."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-Month Consequences of COVID-19 in Patients Discharged from Hospital: A Cohort Study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"766","DOI":"10.14309\/ajg.0000000000000620","article-title":"Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study","volume":"115","author":"Pan","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 Links Amino Acid Malnutrition to Microbial Ecology and Intestinal Inflammation","volume":"487","author":"Hashimoto","year":"2012","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/gutjnl-2021-325989","article-title":"Gut Microbiota Dynamics in a Prospective Cohort of Patients with Post-Acute COVID-19 Syndrome","volume":"71","author":"Liu","year":"2022","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S2468-1253(21)00076-5","article-title":"Gastrointestinal Sequelae 90 Days after Discharge for COVID-19","volume":"6","author":"Weng","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gutjnl-2020-323020","article-title":"Gut Microbiota Composition Reflects Disease Severity and Dysfunctional Immune Responses in Patients with COVID-19","volume":"70","author":"Yeoh","year":"2021","journal-title":"Gut"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"198018","DOI":"10.1016\/j.virusres.2020.198018","article-title":"Gut Microbiota and Covid-19- Possible Link and Implications","volume":"285","author":"Dhar","year":"2020","journal-title":"Virus Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1053\/j.gastro.2020.05.048","article-title":"Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization","volume":"159","author":"Zuo","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2017.10.016","article-title":"Exotoxins and Endotoxins: Inducers of Inflammatory Cytokines","volume":"149","author":"Cavaillon","year":"2018","journal-title":"Toxicon Off. J. Int. Soc. Toxinology"},{"key":"ref_31","first-page":"1843","article-title":"Detection of SARS-CoV-2 in Different Types of Clinical Specimens","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_32","unstructured":"(2022, April 25). Small Intestinal Bacterial Overgrowth (SIBO)|OMICS International. Available online: https:\/\/www.omicsonline.org\/open-access\/small-intestinal-bacterial-overgrowth-sibo-2161-069X.1000225.php?aid=31428."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4103\/sjg.SJG_352_20","article-title":"Nutrition and the Gut Microbiome during Critical Illness: A New Insight of Nutritional Therapy","volume":"26","author":"Zaher","year":"2020","journal-title":"Saudi J. Gastroenterol. Off. J. Saudi Gastroenterol. Assoc."},{"key":"ref_34","first-page":"1622","article-title":"Bacterial Co-Infection and Secondary Infection in Patients with COVID-19: A Living Rapid Review and Meta-Analysis","volume":"26","author":"Langford","year":"2020","journal-title":"Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1080\/10408398.2020.1775546","article-title":"Obesity as a Risk Factor for COVID-19: An Overview","volume":"61","author":"Alberca","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/sjg.sjg_75_21","article-title":"Nutrition and the Microbiota Post-COVID-19","volume":"27","author":"Alberca","year":"2021","journal-title":"Saudi J. Gastroenterol. Off. J. Saudi Gastroenterol. Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tifs.2021.12.033","article-title":"Evidences and Perspectives of the Use of Probiotics, Prebiotics, Synbiotics, and Postbiotics as Adjuvants for Prevention and Treatment of COVID-19: A Bibliometric Analysis and Systematic Review","volume":"120","author":"Padilha","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tim.2021.01.003","article-title":"Shaping the Future of Probiotics and Prebiotics","volume":"29","author":"Cunningham","year":"2021","journal-title":"Trends Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100837","DOI":"10.1016\/j.nmni.2021.100837","article-title":"Oral Probiotics in Coronavirus Disease 2019: Connecting the Gut-Lung Axis to Viral Pathogenesis, Inflammation, Secondary Infection and Clinical Trials","volume":"40","author":"Baindara","year":"2021","journal-title":"New Microbes New Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2174\/1381612824666180116163411","article-title":"Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems","volume":"24","author":"Kanauchi","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3389\/fmicb.2020.01877","article-title":"Probiotics at War Against Viruses: What Is Missing From the Picture?","volume":"11","author":"Tiwari","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Strauss, M., Mi\u010deti\u0107-Turk, D., Poga\u010dar, M.\u0160., and Fijan, S. (2021). Probiotics for the Prevention of Acute Respiratory-Tract Infections in Older People: Systematic Review. Healthcare, 9.","DOI":"10.3390\/healthcare9060690"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3920\/BM2015.0096","article-title":"Absence of Adverse Events in Healthy Individuals Using Probiotics--Analysis of Six Randomised Studies by One Study Group","volume":"7","author":"Tapiovaara","year":"2016","journal-title":"Benef. Microbes"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Montazeri-Najafabady, N., Kazemi, K., and Gholami, A. (2022). Recent Advances in Antiviral Effects of Probiotics: Potential Mechanism Study in Prevention and Treatment of SARS-CoV-2. Biologia, 1\u201318.","DOI":"10.1007\/s11756-022-01147-y"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2567.2009.03204.x","article-title":"Well-Controlled Proinflammatory Cytokine Responses of Peyer\u2019s Patch Cells to Probiotic Lactobacillus Casei","volume":"130","author":"Chiba","year":"2010","journal-title":"Immunology"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Chowdhury, A.H., C\u00e1mara, M., Verma, C., Eremin, O., Kulkarni, A.D., and Lobo, D.N. (2019). Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium Longum, AHCC\u00ae and Azithromycin in Healthy Individuals. Nutrients, 11.","DOI":"10.3390\/nu11102470"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/MCG.0b013e31826a8468","article-title":"Probiotics Reduce Gut Microbial Translocation and Improve Adult Atopic Dermatitis","volume":"46","author":"Iemoli","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.autrev.2016.01.002","article-title":"Induction of Regulatory T Cells: A Role for Probiotics and Prebiotics to Suppress Autoimmunity","volume":"15","author":"Dwivedi","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1178638819882739","DOI":"10.1177\/1178638819882739","article-title":"The Effects of Dietary Polyphenols on Circulating Cardiovascular Disease Biomarkers and Iron Status: A Systematic Review","volume":"12","author":"Speer","year":"2019","journal-title":"Nutr. Metab. Insights"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.etap.2016.03.005","article-title":"Natural Iron Chelators: Protective Role in A549 Cells of Flavonoids-Rich Extracts of Citrus Juices in Fe(3+)-Induced Oxidative Stress","volume":"43","author":"Ferlazzo","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/QAI.0000000000000784","article-title":"Reduced Levels of D-Dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART","volume":"70","author":"Stiksrud","year":"2015","journal-title":"J. Acquir. Immune Defic. Syndr. 1999"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2147\/DDDT.S155110","article-title":"The Influence of Prebiotic or Probiotic Supplementation on Antibody Titers after Influenza Vaccination: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"12","author":"Yeh","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lei, W.-T., Shih, P.-C., Liu, S.-J., Lin, C.-Y., and Yeh, T.-L. (2017). Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 9.","DOI":"10.3390\/nu9111175"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/17474124.2017.1343664","article-title":"From Clinical Uncertainties to Precision Medicine: The Emerging Role of the Gut Barrier and Microbiome in Small Bowel Functional Diseases","volume":"11","author":"Marlicz","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fmed.2020.00389","article-title":"Challenges in the Management of SARS-CoV-2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19","volume":"7","author":"Ceccarelli","year":"2020","journal-title":"Front. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"834","DOI":"10.11569\/wcjd.v28.i17.834","article-title":"Clinical effects of probiotics in ordinary-type COVID-19 patients with diarrhea","volume":"28","author":"Ke","year":"2020","journal-title":"World Chin. J. Dig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2018899","DOI":"10.1080\/19490976.2021.2018899","article-title":"Probiotic Improves Symptomatic and Viral Clearance in Covid19 Outpatients: A Randomized, Quadruple-Blinded, Placebo-Controlled Trial","volume":"14","author":"Abreu","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e047069","DOI":"10.1136\/bmjopen-2020-047069","article-title":"Randomised, Double-Blind, Placebo-Controlled Trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): A Clinical Trial Protocol","volume":"11","author":"Tang","year":"2021","journal-title":"BMJ Open"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41538-020-00078-9","article-title":"The Potential Application of Probiotics and Prebiotics for the Prevention and Treatment of COVID-19","volume":"4","author":"Olaimat","year":"2020","journal-title":"Npj Sci. Food"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Descriptive Study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1111\/all.14289","article-title":"Eleven Faces of Coronavirus Disease 2019","volume":"75","author":"Dong","year":"2020","journal-title":"Allergy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jiph.2020.07.003","article-title":"Molecular Pathogenesis of Secondary Bacterial Infection Associated to Viral Infections Including SARS-CoV-2","volume":"13","author":"Manna","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1445-2197.2005.03285.x","article-title":"Severe Acute Respiratory Syndrome in Surgical Patients: A Diagnostic Dilemma","volume":"75","author":"Tan","year":"2005","journal-title":"ANZ J. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-1605(98)00055-5","article-title":"Survival of Lactobacillus Plantarum DSM 9843 (299v), and Effect on the Short-Chain Fatty Acid Content of Faeces after Ingestion of a Rose-Hip Drink with Fermented Oats","volume":"42","author":"Johansson","year":"1998","journal-title":"Int. J. Food Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/aem.59.1.15-20.1993","article-title":"Administration of Different Lactobacillus Strains in Fermented Oatmeal Soup: In Vivo Colonization of Human Intestinal Mucosa and Effect on the Indigenous Flora","volume":"59","author":"Johansson","year":"1993","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s10620-012-2102-y","article-title":"Lactobacillus Plantarum 299v Does Not Reduce Enteric Bacteria or Bacterial Translocation in Patients Undergoing Colon Resection","volume":"57","author":"Mangell","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1572-0241.2000.02015.x","article-title":"Alteration of Intestinal Microflora Is Associated With Reduction in Abdominal Bloating and Pain in Patients With Irritable Bowel Syndrome","volume":"95","author":"Nobaek","year":"2000","journal-title":"Off. J. Am. Coll. Gastroenterol. ACG"},{"key":"ref_69","first-page":"215","article-title":"Persistence of Lactobacillus Plantarum DSM 9843 on Human Tonsillar Surface after Oral Administration in Fermented Oatmeal Gruel. A Pilot Study","volume":"543","author":"Warfving","year":"2000","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"R285","DOI":"10.1186\/cc3522","article-title":"Adhesion of the Probiotic Bacterium Lactobacillus Plantarum 299v onto the Gut Mucosa in Critically Ill Patients: A Randomised Open Trial","volume":"9","author":"Klarin","year":"2005","journal-title":"Crit. Care"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1128\/aem.62.7.2244-2251.1996","article-title":"A Mannose-Specific Adherence Mechanism in Lactobacillus Plantarum Conferring Binding to the Human Colonic Cell Line HT-29","volume":"62","author":"Adlerberth","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1600-0463.2006.apm_369.x","article-title":"Adhesive Capability of Lactobacillus Plantarum 299v Is Important for Preventing Bacterial Translocation in Endotoxemic Rats","volume":"114","author":"Mangell","year":"2006","journal-title":"APMIS Acta Pathol. Microbiol. Immunol. Scand."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1099\/0022-1317-51-10-837","article-title":"Purification of Native Alpha-Enolase from Streptococcus Pneumoniae That Binds Plasminogen and Is Immunogenic","volume":"51","author":"Whiting","year":"2002","journal-title":"J. Med. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0014-5793(02)02580-2","article-title":"Enhanced Activation of Bound Plasminogen on Staphylococcus Aureus by Staphylokinase","volume":"517","author":"Helin","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/infdis\/166.2.436","article-title":"Streptokinase-Producing Streptococci Grown in Human Plasma Acquire Unregulated Cell-Associated Plasmin Activity","volume":"166","author":"Lottenberg","year":"1992","journal-title":"J. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/IAI.67.3.1086-1092.1999","article-title":"The Staphylococcal Transferrin-Binding Protein Is a Cell Wall Glyceraldehyde-3-Phosphate Dehydrogenase","volume":"67","author":"Modun","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1084\/jem.170.6.2065","article-title":"The Major Parasite Surface Antigen Associated with Human Resistance to Schistosomiasis Is a 37-KD Glyceraldehyde-3P-Dehydrogenase","volume":"170","author":"Caillol","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_78","first-page":"G941","article-title":"Probiotics Inhibit Enteropathogenic, E. Coli Adherence in Vitro by Inducing Intestinal Mucin Gene Expression","volume":"276","author":"Mack","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/gut.52.6.827","article-title":"Extracellular MUC3 Mucin Secretion Follows Adherence of Lactobacillus Strains to Intestinal Epithelial Cells in Vitro","volume":"52","author":"Mack","year":"2003","journal-title":"Gut"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1080\/07391102.2020.1775123","article-title":"Antiviral Effects of Probiotic Metabolites on COVID-19","volume":"39","author":"Anwar","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"100515","DOI":"10.1016\/j.imu.2021.100515","article-title":"Manipulated Bio Antimicrobial Peptides from Probiotic Bacteria as Proposed Drugs for COVID-19 Disease","volume":"23","author":"Balmeh","year":"2021","journal-title":"Inform. Med. Unlocked"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.fct.2019.04.032","article-title":"Reappraisal of Probiotics\u2019 Safety in Human","volume":"129","author":"Sotoudegan","year":"2019","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Costa, R.L., Moreira, J., Lorenzo, A., and Lamas, C.C. (2018). Infectious Complications Following Probiotic Ingestion: A Potentially Underestimated Problem? A Systematic Review of Reports and Case Series. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2394-3"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert Consensus Document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_86","first-page":"276","article-title":"Quality of Probiotic Products for Preterm Infants: Contamination and Missing Strains","volume":"109","author":"Vermeulen","year":"2020","journal-title":"Acta Paediatr. Oslo Nor. 1992"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","article-title":"The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Synbiotics","volume":"17","author":"Swanson","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_88","unstructured":"(2022, April 28). Update of the List of QPS-Recommended Biological Agents Intentionally Added to Food or Feed as Notified to EFSA 13: Suitability of Taxonomic Units Notified to EFSA until September 2020|EFSA. Available online: https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/6377."},{"key":"ref_89","unstructured":"Center for Veterinary Medicine, and Center for Food Safety and Applied Nutrition (2022, April 28). Guidance for Industry: Regulatory Framework for Substances Intended for Use in Human Food or Animal Food on the Basis of the Generally Recognized as Safe (GRAS) Provision of the Federal Food, Drug, and Cosmetic Act, Available online: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/guidance-industry-regulatory-framework-substances-intended-use-human-food-or-animal-food-basis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.copbio.2014.11.021","article-title":"Novel Probiotics and Prebiotics: Road to the Market","volume":"32","author":"Kumar","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_91","unstructured":"(2022, August 14). EMA European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Boyle, R.J., Robins-Browne, R.M., and Tang, M.L.K. (2006). Probiotic Use in Clinical Practice: What Are the Risks?. Am. J. Clin. Nutr., 83.","DOI":"10.1093\/ajcn\/83.6.1256"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"109136","DOI":"10.1016\/j.foodres.2020.109136","article-title":"Chemistry and Microbial Sources of Curdlan with Potential Application and Safety Regulations as Prebiotic in Food and Health","volume":"133","author":"Verma","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3389\/fmicb.2020.01662","article-title":"Criteria to Qualify Microorganisms as \u201cProbiotic\u201d in Foods and Dietary Supplements","volume":"11","author":"Binda","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"102598","DOI":"10.1016\/j.ifset.2020.102598","article-title":"Multiparameter Flow Cytometric Enumeration of Probiotic-Containing Commercial Powders","volume":"68","author":"Sielatycka","year":"2021","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"10179","DOI":"10.3390\/nu7125526","article-title":"The Effect of Lactobacillus Plantarum 299v on the Incidence of Clostridium Difficile Infection in High Risk Patients Treated with Antibiotics","volume":"7","author":"Adamczak","year":"2015","journal-title":"Nutrients"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1159\/000484428","article-title":"Clostridium Difficile Infection in the Nephrology Ward","volume":"42","author":"Dudzicz","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"ref_98","first-page":"809","article-title":"The Unregulated Probiotic Market","volume":"17","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/jmv.26105","article-title":"Potential Neuroinvasive Pathways of SARS-CoV-2: Deciphering the Spectrum of Neurological Deficit Seen in Coronavirus Disease-2019 (COVID-19)","volume":"92","author":"Baig","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.virusres.2011.12.021","article-title":"Coronavirus Infection of Rat Dorsal Root Ganglia: Ultrastructural Characterization of Viral Replication, Transfer, and the Early Response of Satellite Cells","volume":"163","author":"Li","year":"2012","journal-title":"Virus Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnana.2020.00037","article-title":"Neuromechanisms of SARS-CoV-2: A Review","volume":"14","author":"DosSantos","year":"2020","journal-title":"Front. Neuroanat."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/acschemneuro.0c00172","article-title":"SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection","volume":"11","author":"Butowt","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Gudowska-Sawczuk, M., and Mroczko, B. (2021). The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132772"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41593-020-00758-5","article-title":"Olfactory Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals with COVID-19","volume":"24","author":"Meinhardt","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbi.2020.04.060","article-title":"Can the Enteric Nervous System Be an Alternative Entrance Door in SARS-CoV2 Neuroinvasion?","volume":"87","author":"Esposito","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Skonieczna-\u017bydecka, K., Marlicz, W., Misera, A., Koulaouzidis, A., and \u0141oniewski, I. (2018). Microbiome-The Missing Link in the Gut-Brain Axis: Focus on Its Role in Gastrointestinal and Mental Health. J. Clin. Med., 7.","DOI":"10.20944\/preprints201810.0554.v1"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jmv.25825","article-title":"The Presence of SARS-CoV-2 RNA in the Feces of COVID-19 Patients","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"100081","DOI":"10.1016\/j.bbih.2020.100081","article-title":"How to Detect and Track Chronic Neurologic Sequelae of COVID-19? Use of Auditory Brainstem Responses and Neuroimaging for Long-Term Patient Follow-Up","volume":"5","author":"Ogier","year":"2020","journal-title":"Brain Behav. Immun.-Health"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/jmv.25915","article-title":"Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)","volume":"92","author":"Bryce","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_110","first-page":"3738","article-title":"Infection Mechanism of SARS-CoV-2 and Its Implication on the Nervous System","volume":"11","author":"Minjarez","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11684-020-0786-5","article-title":"Neurological Manifestations of Patients with COVID-19: Potential Routes of SARS-CoV-2 Neuroinvasion from the Periphery to the Brain","volume":"14","author":"Li","year":"2020","journal-title":"Front. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coi.2015.10.008","article-title":"Mechanisms of Restriction of Viral Neuroinvasion at the Blood-Brain Barrier","volume":"38","author":"Miner","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"102799","DOI":"10.1016\/j.ebiom.2020.102799","article-title":"Infectivity of Human Coronavirus in the Brain","volume":"56","author":"Cheng","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbi.2020.04.027","article-title":"Are We Facing a Crashing Wave of Neuropsychiatric Sequelae of COVID-19? Neuropsychiatric Symptoms and Potential Immunologic Mechanisms","volume":"87","author":"Troyer","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.genhosppsych.2009.03.001","article-title":"Long-Term Psychiatric Morbidities among SARS Survivors","volume":"31","author":"Mak","year":"2009","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2215-0366(20)30307-2","article-title":"How Mental Health Care Should Change as a Consequence of the COVID-19 Pandemic","volume":"7","author":"Moreno","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and Disorders of the Stress System","volume":"5","author":"Chrousos","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12992-017-0237-5","article-title":"The Role of Unhealthy Lifestyles in the Incidence and Persistence of Depression: A Longitudinal General Population Study in Four Emerging Countries","volume":"13","author":"Cabello","year":"2017","journal-title":"Glob. Health"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jad.2021.09.090","article-title":"Physical and Mental Health Impact of COVID-19 on Children, Adolescents, and Their Families: The Collaborative Outcomes Study on Health and Functioning during Infection Times\u2014Children and Adolescents (COH-FIT-C&A)","volume":"299","author":"Solmi","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jad.2021.07.048","article-title":"The Collaborative Outcomes Study on Health and Functioning during Infection Times in Adults (COH-FIT-Adults): Design and Methods of an International Online Survey Targeting Physical and Mental Health Effects of the COVID-19 Pandemic","volume":"299","author":"Solmi","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/jmv.27549","article-title":"A Large Scale Meta-Analytic Atlas of Mental Health Problems Prevalence during the COVID-19 Early Pandemic","volume":"94","author":"Dragioti","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/gutjnl-2020-320926","article-title":"Epidemiological, Clinical and Virological Characteristics of 74 Cases of Coronavirus-Infected Disease 2019 (COVID-19) with Gastrointestinal Symptoms","volume":"69","author":"Jin","year":"2020","journal-title":"Gut"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S2468-1253(20)30118-7","article-title":"Enteric Involvement in Hospitalised Patients with COVID-19 Outside Wuhan","volume":"5","author":"Wan","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2020.04.045","article-title":"Prevalence and Characteristics of Gastrointestinal Symptoms in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study","volume":"159","author":"Redd","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1053\/j.gastro.2020.04.008","article-title":"High Prevalence of Concurrent Gastrointestinal Manifestations in Patients With Severe Acute Respiratory Syndrome Coronavirus 2: Early Experience From California","volume":"159","author":"Cholankeril","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/all.14238","article-title":"Clinical Characteristics of 140 Patients Infected with SARS-CoV-2 in Wuhan, China","volume":"75","author":"Zhang","year":"2020","journal-title":"Allergy"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2020.03.065","article-title":"Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-Analysis","volume":"159","author":"Cheung","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.26424","article-title":"Epidemiology of COVID-19: A Systematic Review and Meta-Analysis of Clinical Characteristics, Risk Factors, and Outcomes","volume":"93","author":"Li","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.mayocp.2021.04.011","article-title":"Lack of Marked Association Between Gastrointestinal Symptoms and COVID-19 Mortality: An Updated Meta-Analysis Based on Adjusted Effect Estimates","volume":"96","author":"Li","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.25822","article-title":"Imaging and Clinical Features of Patients with 2019 Novel Coronavirus SARS-CoV-2: A Systematic Review and Meta-Analysis","volume":"92","author":"Cao","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/j.gastro.2020.05.001","article-title":"AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19","volume":"159","author":"Sultan","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cell.2022.01.014","article-title":"Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae","volume":"185","author":"Su","year":"2022","journal-title":"Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12015-020-10010-z","article-title":"SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45- Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome","volume":"17","author":"Ratajczak","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/j.gastro.2020.07.067","article-title":"The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection","volume":"160","author":"Penninger","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109951","DOI":"10.1016\/j.pnpbp.2020.109951","article-title":"The HPA Axis Dysregulation in Severe Mental Illness: Can We Shift the Blame to Gut Microbiota?","volume":"102","author":"Misiak","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"815798","DOI":"10.3389\/fcimb.2022.815798","article-title":"Treatment With Multi-Species Probiotics Changes the Functions, Not the Composition of Gut Microbiota in Postmenopausal Women With Obesity: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"12","author":"Kaczmarczyk","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7861\/clinmed.2021-0522","article-title":"COVID-19 Infection Causing Residual Gastrointestinal Symptoms\u2014A Single UK Centre Case Series","volume":"22","author":"Cooney","year":"2022","journal-title":"Clin. Med."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Abate, S.M., Ahmed Ali, S., Mantfardo, B., and Basu, B. (2020). Rate of Intensive Care Unit Admission and Outcomes among Patients with Coronavirus: A Systematic Review and Meta-Analysis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235653"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/anae.15201","article-title":"Outcomes from Intensive Care in Patients with COVID-19: A Systematic Review and Meta-Analysis of Observational Studies","volume":"75","author":"Armstrong","year":"2020","journal-title":"Anaesthesia"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13613-021-00820-w","article-title":"Intensive Care Management of Patients with COVID-19: A Practical Approach","volume":"11","author":"Hajjar","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"ref_143","first-page":"100186","article-title":"Long Covid in Adults Discharged from UK Hospitals after Covid-19: A Prospective, Multicentre Cohort Study Using the ISARIC WHO Clinical Characterisation Protocol","volume":"8","author":"Sigfrid","year":"2021","journal-title":"Lancet Reg. Health-Eur."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/00042737-200110000-00004","article-title":"A Controlled, Double-Blind, Randomized Study on the Efficacy of Lactobacillus Plantarum 299V in Patients with Irritable Bowel Syndrome","volume":"13","author":"Niedzielin","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gutjnl-2021-324598","article-title":"British Society of Gastroenterology Guidelines on the Management of Irritable Bowel Syndrome","volume":"70","author":"Vasant","year":"2021","journal-title":"Gut"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"369","DOI":"10.5114\/pg.2021.111766","article-title":"Probiotics in Irritable Bowel Syndrome\u2014Is the Quest for the Right Strain over? Rapid Review of Existing Guidelines and Recommendations","volume":"16","author":"Marlicz","year":"2021","journal-title":"Gastroenterol. Rev. Gastroenterol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"101154","DOI":"10.1016\/j.eclinm.2021.101154","article-title":"Strain-Specific and Outcome-Specific Efficacy of Probiotics for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis","volume":"41","author":"McFarland","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_148","first-page":"125","article-title":"[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment\u2014Real-life data of a non-interventional study in Germany]","volume":"59","author":"Krammer","year":"2021","journal-title":"Z. Gastroenterol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jhn.12385","article-title":"British Dietetic Association Systematic Review and Evidence-Based Practice Guidelines for the Dietary Management of Irritable Bowel Syndrome in Adults (2016 Update)","volume":"29","author":"McKenzie","year":"2016","journal-title":"J. Hum. Nutr. Diet. Off. J. Br. Diet. Assoc."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-277X.2012.01242.x","article-title":"British Dietetic Association Evidence-Based Guidelines for the Dietary Management of Irritable Bowel Syndrome in Adults","volume":"25","author":"McKenzie","year":"2012","journal-title":"J. Hum. Nutr. Diet. Off. J. Br. Diet. Assoc."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/MCG.0000000000000420","article-title":"Recommendations for Probiotic Use\u20142015 Update: Proceedings and Consensus Opinion","volume":"49","author":"Floch","year":"2015","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1097\/MCG.0b013e318230928b","article-title":"Recommendations for Probiotic Use-2011 Update","volume":"45","author":"Floch","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_153","unstructured":"(2022, August 14). World Gastroenterology Organisation (WGO). Available online: https:\/\/www.worldgastroenterology.org."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"831193","DOI":"10.3389\/fnins.2021.831193","article-title":"Impending Mental Health Issues During Coronavirus Disease 2019\u2014Time for Personalized Nutrition Based on the Gut Microbiota to Tide Over the Crisis?","volume":"15","author":"Dhar","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2020.05.026","article-title":"Prevalence of Depression, Anxiety, and Insomnia among Healthcare Workers during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis","volume":"88","author":"Pappa","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2215-0366(20)30203-0","article-title":"Psychiatric and Neuropsychiatric Presentations Associated with Severe Coronavirus Infections: A Systematic Review and Meta-Analysis with Comparison to the COVID-19 Pandemic","volume":"7","author":"Rogers","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"110111","DOI":"10.1016\/j.pnpbp.2020.110111","article-title":"Major Depressive Disorder and Gut Microbiota\u2014Association Not Causation. A Scoping Review","volume":"106","author":"Misera","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s13668-020-00313-5","article-title":"Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry","volume":"9","author":"Butler","year":"2020","journal-title":"Curr. Nutr. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e2019686","DOI":"10.1001\/jamanetworkopen.2020.19686","article-title":"Prevalence of Depression Symptoms in US Adults Before and During the COVID-19 Pandemic","volume":"3","author":"Ettman","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.biopsych.2013.05.001","article-title":"Psychobiotics: A Novel Class of Psychotropic","volume":"74","author":"Dinan","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1017\/S0007114511005137","article-title":"Combination of Lactobacillus Helveticus R0052 and Bifidobacterium Longum R0175 Reduces Post-Myocardial Infarction Depression Symptoms and Restores Intestinal Permeability in a Rat Model","volume":"107","author":"Rondeau","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/nmo.12540","article-title":"Vagotomy Prevents the Effect of Probiotics on Caspase Activity in a Model of Postmyocardial Infarction Depression","volume":"27","author":"Malick","year":"2015","journal-title":"Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e823","DOI":"10.1038\/tp.2016.94","article-title":"The Effects of a Probiotic Formulation (Lactobacillus Rhamnosus and L. Helveticus) on Developmental Trajectories of Emotional Learning in Stressed Infant Rats","volume":"6","author":"Cowan","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"589","DOI":"10.5056\/jnm16018","article-title":"Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review","volume":"22","author":"Wang","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S0007114510004319","article-title":"Assessment of Psychotropic-like Properties of a Probiotic Formulation (Lactobacillus Helveticus R0052 and Bifidobacterium Longum R0175) in Rats and Human Subjects","volume":"105","author":"Messaoudi","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/gut.2006.117176","article-title":"Probiotic Treatment of Rat Pups Normalises Corticosterone Release and Ameliorates Colonic Dysfunction Induced by Maternal Separation","volume":"56","author":"Gareau","year":"2007","journal-title":"Gut"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the Individual. Mechanisms Leading to Disease","volume":"153","author":"McEwen","year":"1993","journal-title":"Arch. Intern. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neubiorev.2014.06.004","article-title":"Refining and Integrating Schizophrenia Pathophysiology\u2014Relevance of the Allostatic Load Concept","volume":"45","author":"Misiak","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1042\/BST20190110","article-title":"Allostatic Load and Ageing: Linking the Microbiome and Nutrition with Age-Related Health","volume":"47","author":"Shiels","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1017\/S0007114509990766","article-title":"Lactobacillus Helveticus and Bifidobacterium Longum Taken in Combination Reduce the Apoptosis Propensity in the Limbic System after Myocardial Infarction in a Rat Model","volume":"102","author":"Girard","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1177\/0956797616653103","article-title":"Treating Generational Stress: Effect of Paternal Stress on Development of Memory and Extinction in Offspring Is Reversed by Probiotic Treatment","volume":"27","author":"Callaghan","year":"2016","journal-title":"Psychol. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2007.10.001","article-title":"Probiotic Food Supplement Reduces Stress-Induced Gastrointestinal Symptoms in Volunteers: A Double-Blind, Placebo-Controlled, Randomized Trial","volume":"28","author":"Diop","year":"2008","journal-title":"Nutr. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"110076","DOI":"10.1016\/j.pnpbp.2020.110076","article-title":"Analysis of Gut Microbiota and Intestinal Integrity Markers of Inpatients with Major Depressive Disorder","volume":"106","author":"Kaczmarczyk","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Li\u015bkiewicz, P., Pe\u0142ka-Wysiecka, J., Kaczmarczyk, M., \u0141oniewski, I., Wro\u0144ski, M., B\u0105ba-Kubi\u015b, A., Skonieczna-\u017bydecka, K., Marlicz, W., Misiak, B., and Samochowiec, J. (2019). Fecal Microbiota Analysis in Patients Going through a Depressive Episode during Treatment in a Psychiatric Hospital Setting. J. Clin. Med., 8.","DOI":"10.3390\/jcm8020164"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Misera, A., Li\u015bkiewicz, P., \u0141oniewski, I., Skonieczna-\u017bydecka, K., and Samochowiec, J. (2021). Effect of Psychobiotics on Psychometric Tests and Inflammatory Markers in Major Depressive Disorder: Meta-Analysis of Randomized Controlled Trials with Meta-Regression. Pharmaceuticals, 14.","DOI":"10.3390\/ph14100952"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5056\/jnm20079","article-title":"Effects of a Psychobiotic Supplement on Serum Brain-Derived Neurotrophic Factor Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical Trial","volume":"26","author":"Kazemi","year":"2020","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/1028415X.2019.1598669","article-title":"Efficacy of a Multispecies Probiotic as Adjunctive Therapy in Generalized Anxiety Disorder: A Double Blind, Randomized, Placebo-Controlled Trial","volume":"24","author":"Eskandarzadeh","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jad.2022.02.024","article-title":"Stressful Events Induce Long-Term Gut Microbiota Dysbiosis and Associated Post-Traumatic Stress Symptoms in Healthcare Workers Fighting against COVID-19","volume":"303","author":"Gao","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/nmo.12804","article-title":"Probiotic Lactobacillus Casei Strain Shirota Relieves Stress-Associated Symptoms by Modulating the Gut-Brain Interaction in Human and Animal Models","volume":"28","author":"Takada","year":"2016","journal-title":"Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3920\/BM2018.0135","article-title":"Lactobacillus Plantarum DR7 Alleviates Stress and Anxiety in Adults: A Randomised, Double-Blind, Placebo-Controlled Study","volume":"10","author":"Chong","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_181","first-page":"486","article-title":"Probiotics Drive Gut Microbiome Triggering Emotional Brain Signatures","volume":"9","author":"Bagga","year":"2018","journal-title":"Gut Microbes"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/sj.ejcn.1602546","article-title":"Impact of Consuming a Milk Drink Containing a Probiotic on Mood and Cognition","volume":"61","author":"Benton","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1757-4749-1-6","article-title":"A Randomized, Double-Blind, Placebo-Controlled Pilot Study of a Probiotic in Emotional Symptoms of Chronic Fatigue Syndrome","volume":"1","author":"Rao","year":"2009","journal-title":"Gut Pathog."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4161\/gmic.2.4.16108","article-title":"Beneficial Psychological Effects of a Probiotic Formulation (Lactobacillus Helveticus R0052 and Bifidobacterium Longum R0175) in Healthy Human Volunteers","volume":"2","author":"Messaoudi","year":"2011","journal-title":"Gut Microbes"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbi.2015.04.003","article-title":"A Randomized Controlled Trial to Test the Effect of Multispecies Probiotics on Cognitive Reactivity to Sad Mood","volume":"48","author":"Steenbergen","year":"2015","journal-title":"Brain. Behav. Immun."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.psyneuen.2018.10.010","article-title":"Probiotic Lactobacillus Plantarum 299v Decreases Kynurenine Concentration and Improves Cognitive Functions in Patients with Major Depression: A Double-Blind, Randomized, Placebo Controlled Study","volume":"100","author":"Rudzki","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/jhn.12675","article-title":"Effect of Probiotic and Prebiotic versus Placebo on Appetite in Patients with Major Depressive Disorder: Post Hoc Analysis of a Randomised Clinical Trial","volume":"33","author":"Kazemi","year":"2020","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jff.2018.11.041","article-title":"Effect of Prebiotic and Probiotic Supplementation on Circulating Pro-Inflammatory Cytokines and Urinary Cortisol Levels in Patients with Major Depressive Disorder: A Double-Blind, Placebo-Controlled Randomized Clinical Trial","volume":"52","author":"Kazemi","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e60507","DOI":"10.5812\/archneurosci.60507","article-title":"The Effect of Synbiotic as an Adjuvant Therapy to Fluoxetine in Moderate Depression: A Randomized Multicenter Trial","volume":"5","author":"Ghorbani","year":"2018","journal-title":"Arch. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jad.2019.04.097","article-title":"Gut Feelings: A Randomised, Triple-Blind, Placebo-Controlled Trial of Probiotics for Depressive Symptoms","volume":"253","author":"Chahwan","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.nut.2015.09.003","article-title":"Clinical and Metabolic Response to Probiotic Administration in Patients with Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"32","author":"Akkasheh","year":"2016","journal-title":"Nutrition"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"19m02578","DOI":"10.4088\/PCC.19m02578","article-title":"Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"22","author":"Saccarello","year":"2020","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Reininghaus, E.Z., Platzer, M., Kohlhammer-Dohr, A., Hamm, C., M\u00f6rkl, S., Bengesser, S.A., Fellendorf, F.T., Lahousen-Luxenberger, T., Leitner-Afschar, B., and Sch\u00f6ggl, H. (2020). PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression\u2014A Randomized Controlled Trial. Nutrients, 12.","DOI":"10.3390\/nu12113422"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Reiter, A., Bengesser, S.A., Hauschild, A.-C., Birkl-T\u00f6glhofer, A.-M., Fellendorf, F.T., Platzer, M., F\u00e4rber, T., Seidl, M., Mendel, L.-M., and Unterweger, R. (2020). Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder-Preliminary Results of the PROVIT Study. Nutrients, 12.","DOI":"10.3390\/nu12092575"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5155\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:21:12Z","timestamp":1760142072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":194,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11175155"],"URL":"https:\/\/doi.org\/10.3390\/jcm11175155","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}