{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:04:07Z","timestamp":1790723047418,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: To investigate the prevalence of symptoms and signs of laryngopharyngeal reflux (LPR) and to compare them with the otolaryngologist-estimated prevalence of the most common LPR-related symptoms and signs. Methods: The prevalence of LPR symptoms and signs was determined through the clinical data of 403 patients with a positive LPR diagnosis on hypopharyngeal\u2013esophageal multichannel intraluminal impedance pH monitoring. The otolaryngologist-estimated prevalence was assessed through an international survey investigating the thoughts of 824 otolaryngologists toward LPR symptom and sign prevalence. The determination of potential over- or underestimation of LPR symptoms and findings was investigated through a data comparison between the \u2018true\u2019 prevalence and the \u2018estimated prevalence\u2019 of symptoms and findings by otolaryngologists. Results: The prevalence of breathing difficulties, coated tongue, and ventricular band inflammation was adequately evaluated by otolaryngologists. The prevalence of hoarseness, throat pain, odynophagia, dysphagia, throat clearing, globus sensation, excess throat mucus, tongue burning, heartburn, regurgitations, halitosis, cough after eating or lying down, and troublesome cough was overestimated by otolaryngologists (p &lt; 0.01), while the prevalence of chest pain was underestimated as an LPR symptom. Most laryngeal signs, e.g., arytenoid\/laryngeal erythema, inter-arytenoid granulation, posterior commissure hypertrophy, retrocricoid edema\/erythema, and endolaryngeal sticky mucus, were overestimated (p &lt; 0.01). The occurrence of anterior pillar erythema and tongue tonsil hypertrophy was underestimated by participants. Conclusion: Most laryngopharyngeal reflux symptoms and laryngeal signs were overestimated by otolaryngologists, while some non-laryngeal findings were underestimated. Future studies are needed to better understand the reasons for this phenomenon and to improve the awareness of otolaryngologists toward the most and least prevalent reflux symptoms and signs.<\/jats:p>","DOI":"10.3390\/jcm11175192","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:27:17Z","timestamp":1662067637000},"page":"5192","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Do Otolaryngologists Over- or Underestimate Laryngopharyngeal Reflux Symptoms and Findings in Clinical Practice? A Comparison Study between the True Prevalence and the Otolaryngologist-Estimated Prevalence of Symptoms and Findings"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Polyclinic of Poitiers, Elsan Hospital, 86000 Poitiers, France"},{"name":"Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), B7000 Mons, Belgium"},{"name":"Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, B7000 Baudour, Belgium"},{"name":"Department of Otolaryngology-Head and Neck Surgery, EpiCURA Hospital, Rue L. Cathy, University of Mons, B7000 Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0194599819827488","article-title":"Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review","volume":"160","author":"Lechien","year":"2019","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.giec.2019.12.004","article-title":"Laryngopharyngeal Reflux and Atypical Gastroesophageal Reflux Disease","volume":"30","author":"Barrett","year":"2020","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.294.12.1534","article-title":"Evaluation and management of laryngopharyngeal reflux","volume":"294","author":"Ford","year":"2005","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E1589","DOI":"10.1002\/lary.29270","article-title":"Management of Laryngopharyngeal Reflux Around the World: An International Study","volume":"131","author":"Lechien","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/lary.28962","article-title":"Changes of Laryngeal and Extralaryngeal Symptoms and Findings in Laryngopharyngeal Reflux Patients","volume":"131","author":"Lechien","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00405-021-06705-9","article-title":"Reflux clinic: Proof-of-concept of a Multidisciplinary European Clinic","volume":"278","author":"Lechien","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/01945998211029831","article-title":"Sensitivity, Specificity and Predictive Values of Laryngopharyngeal Reflux Symptoms and Signs in Clinical Practice","volume":"166","author":"Lechien","year":"2022","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/coa.13722","article-title":"The efficacy of a personalised treatment depending on the characteristics of reflux at multichannel intraluminal impedance-pH monitoring in patients with acid, non-acid and mixed laryngopharyngeal reflux","volume":"46","author":"Lechien","year":"2021","journal-title":"Clin. Otolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lechien, J.R., Chan, W.W., Akst, L.M., Hoppo, T., Jobe, B.A., Chiesa-Estomba, C.M., Muls, V., Bobin, F., Saussez, S., and Carroll, T.L. (2021). Normative Ambulatory Reflux Monitoring Metrics for Laryngopharyngeal Reflux: A Systematic Review of 720 Healthy Individuals. Otolaryngol.-Head Neck Surg., 166.","DOI":"10.1177\/01945998211029831"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E98","DOI":"10.1002\/lary.28017","article-title":"Validity and reliability of the reflux symptom score","volume":"130","author":"Lechien","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/0003489419888947","article-title":"Validity and Reliability of the Reflux Sign Assessment","volume":"129","author":"Lechien","year":"2020","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00405-021-06710-y","article-title":"Impact of subspecialty training on management of laryngopharyngeal reflux: Results of a worldwide survey","volume":"278","author":"Lechien","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00405-012-2244-8","article-title":"Over-diagnosis of laryngopharyngeal reflux as the cause of hoarseness","volume":"270","author":"Thomas","year":"2013","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lechien, J.R., Saussez, S., Muls, V., Barillari, M.R., Chiesa-Estomba, C.M., Hans, S., and Karkos, P.D. (2020). Laryngopharyngeal Reflux: A State-of-the-Art Algorithm Management for Primary Care Physicians. J. Clin. Med., 9.","DOI":"10.20944\/preprints202010.0364.v1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0194599816664330","article-title":"Patient-Reported Outcome Measures Related to Laryngopharyngeal Reflux: A Systematic Review of Instrument Development and Validation","volume":"155","author":"Francis","year":"2016","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/lary.27537","article-title":"Instruments evaluating the clinical findings of laryngopharyngeal reflux: A systematic review","volume":"129","author":"Lechien","year":"2019","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/0194599817697055","article-title":"PepsinA as a Marker of Laryngopharyngeal Reflux Detected in Chronic Rhinosinusitis Patients","volume":"156","author":"Ren","year":"2017","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/00005537-200409000-00012","article-title":"Laryngeal findings in users of combination corticosteroid and bronchodilator therapy","volume":"114","author":"Mirza","year":"2004","journal-title":"Laryngoscope"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J. Voice"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/0003489420921424","article-title":"The Impact of Laryngopharyngeal Reflux on Patient-reported Measures of Chronic Rhinosinusitis","volume":"129","author":"Brown","year":"2020","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaip.2017.04.039","article-title":"The Utility of the Reflux Symptom Index for Diagnosis of Laryngopharyngeal Reflux in an Allergy Patient Population","volume":"6","author":"Brauer","year":"2018","journal-title":"J. Allergy. Clin. Immunol. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"389.e27","DOI":"10.1016\/j.jvoice.2014.08.006","article-title":"Voice disorders in the general Greek population and in patients with laryngopharyngeal reflux. Prevalence and risk factors","volume":"29","author":"Spantideas","year":"2015","journal-title":"J. Voice"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","article-title":"The validity and reliability of the reflux finding score (RFS)","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/lary.28756","article-title":"Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples","volume":"131","author":"Lechien","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00405-019-05482-w","article-title":"Association between laryngopharyngeal reflux disease and autonomic nervedysfunction","volume":"276","author":"Wang","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5192\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:22:03Z","timestamp":1760142123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":25,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11175192"],"URL":"https:\/\/doi.org\/10.3390\/jcm11175192","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}