{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:28:09Z","timestamp":1781278089246,"version":"3.54.1"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shuangqing Talent Program Project of Guangdong Provincial people\u2032s Hospital","award":["KJ012019095"],"award-info":[{"award-number":["KJ012019095"]}]},{"name":"2022 \u201cthe Fundamental Research Funds for the Central Universities\u201d","award":["KJ012019095"],"award-info":[{"award-number":["KJ012019095"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The study aimed to evaluate the diagnostic performance of optical coherence tomography (OCT) in identifying functionally significant coronary stenosis in a vessel with single stenosis. Background: The OCT-based morphofunctional computational method for deriving the optical flow ratio (OFR) has diagnostic value, as it can identify the functional severity of coronary stenosis, but the ability of the OFR to aid the OCT in determining coronary stenosis hemodynamics in single-stenosis lesion remains unclear. Methods: 74 vessels with single stenosis were studied in 69 patients; all cases were performed through OCT and quantitative flow ratio (QFR), and OCT images were used to perform OFR. Results: Among vessels with single stenosis, OFR showed a good correlation with QFR (r = 0.86; p &lt; 0.001). Taking QFR as the standard, the vessel-level diagnosis accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of OFR were 90% (95% CI: 81 to 96), 94% (95% CI: 77 to 99), 88% (95% CI: 74 to 96), 85% (95% CI: 68 to 94) and 95% (95% CI: 82 to 99), respectively. Among vessels with OFR\/QFR concordance, both the minimum lumen area (MLA) and minimum lumen diameter (MLD) showed excellent diagnostic efficiency (MLA: area under the curve (AUC) = 0.92, 95% CI: 0.85 to 0.98, p &lt; 0.001; MLD: AUC = 0.93, 95% CI: 0.86 to 0.98, p &lt; 0.001) in determining the functional significance of coronary stenosis in a single stenosis lesion, and the best cutoff values were 1.55 mm2 and 1.40 mm. Conclusions: OFR has a good correlation with QFR. OCT-measured MLA and MLD have excellent diagnostic efficiency in identifying the hemodynamic significance of coronary stenosis in a vessel with single stenosis.<\/jats:p>","DOI":"10.3390\/jcm11175198","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T20:52:51Z","timestamp":1662497571000},"page":"5198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Morphometric Assessment for Functional Evaluation of Coronary Stenosis with Optical Coherence Tomography and the Optical Flow Ratio in a Vessel with Single Stenosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-1670","authenticated-orcid":false,"given":"Yuming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehuo","family":"Lin","sequence":"additional","affiliation":[{"name":"Shantou University Medical College, Shantou 515041, China"},{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanmin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-623X","authenticated-orcid":false,"given":"Yuanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianjin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1161\/01.CIR.103.24.2928","article-title":"Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: A randomized trial","volume":"103","author":"Bech","year":"2001","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa0807611","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention","volume":"360","author":"Tonino","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1205361","article-title":"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease","volume":"367","author":"Pijls","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5603\/CJ.a2019.0054","article-title":"Consensus document for invasive coronary physiologic assessment in Asia-Pacific countries","volume":"26","author":"Lee","year":"2019","journal-title":"Cardiol. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jcin.2016.07.013","article-title":"Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study","volume":"9","author":"Tu","year":"2016","journal-title":"JACC Cardiovasc Interv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.jacc.2017.10.035","article-title":"Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis","volume":"70","author":"Xu","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4244\/EIJ-D-19-01034","article-title":"Diagnostic performance of intracoronary optical coherence tomography-based versus angiography-based fractional flow reserve for the evaluation of coronary lesions","volume":"16","author":"Huang","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jacc.2011.09.078","article-title":"Morphometric Assessment of Coronary Stenosis Relevance With Optical Coherence Tomography: A Comparison With Fractional Flow Reserve and Intravascular Ultrasound","volume":"59","author":"Gonzalo","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/S0140-6736(16)31922-5","article-title":"Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation (ILUMIEN III: OPTIMIZE PCI): A randomised controlled trial","volume":"388","author":"Ali","year":"2016","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/eurheartj\/ehz332","article-title":"Clinical use of intracoronary imaging. Part 2: Acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions","volume":"40","author":"Johnson","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jacc.2012.12.012","article-title":"FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study","volume":"61","author":"Waksman","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jjcc.2013.11.009","article-title":"Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters","volume":"64","author":"Zafar","year":"2014","journal-title":"J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ahj.2015.01.013","article-title":"Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions","volume":"169","author":"Barbero","year":"2015","journal-title":"Am. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Milzi, A., Dettori, R., Burgmaier, K., Marx, N., Reith, S., and Burgmaier, M. (2021). Quantitative Flow Ratio Is Related to Intraluminal Coronary Stenosis Parameters as Assessed with Optical Coherence Tomography. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091856"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMoa1803538","article-title":"Five-Year Outcomes with PCI Guided by Fractional Flow Reserve","volume":"379","author":"Xaplanteris","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(15)00057-4","article-title":"Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial","volume":"386","author":"Zimmermann","year":"2015","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12933-016-0464-8","article-title":"Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) prospective study. Rationale and design","volume":"15","author":"Kennedy","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e011728","DOI":"10.1161\/CIRCINTERVENTIONS.121.011728","article-title":"Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT\u2013FFR Trial","volume":"15","author":"Fabris","year":"2022","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jcin.2009.06.019","article-title":"Intracoronary Optical Coherence Tomography: A Comprehensive Review: Clinical and Research Applications","volume":"2","author":"Bezerra","year":"2009","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4244\/EIJ-D-19-00182","article-title":"Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity","volume":"15","author":"Yu","year":"2019","journal-title":"EuroIntervention"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/ccd.29592","article-title":"Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law","volume":"97","author":"Tu","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4244\/EIJV6I5A97","article-title":"Safety and feasibility of frequency domain optical coherence tomography to guide decision making in percutaneous coronary intervention","volume":"6","author":"Imola","year":"2010","journal-title":"EuroIntervention"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00392-014-0759-2","article-title":"Correlation between optical coherence tomography-derived intraluminal parameters and fractional flow reserve measurements in intermediate grade coronary lesions: A comparison between diabetic and non-diabetic patients","volume":"104","author":"Reith","year":"2015","journal-title":"Clin. Res. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1253\/circj.CJ-12-0195","article-title":"Optical Coherence Tomography-Derived Anatomical Criteria for Functionally Significant Coronary Stenosis Assessed by Fractional Flow Reserve","volume":"76","author":"Shiono","year":"2012","journal-title":"Circ. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.ahj.2013.08.016","article-title":"Quantitative angiography and optical coherence tomography for the functional assessment of nonobstructive coronary stenoses: Comparison with fractional flow reserve","volume":"166","author":"Pyxaras","year":"2013","journal-title":"Am. Heart J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5198\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:22:23Z","timestamp":1760142143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":25,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11175198"],"URL":"https:\/\/doi.org\/10.3390\/jcm11175198","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]}}}