{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:11:18Z","timestamp":1791436278288,"version":"4.3.3"},"reference-count":34,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Radiology and Medical Informatics department of the Faculty of Medicine of the Geneva University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the causes of pulmonary hypertension (PH) and requires invasive measurement of the mean pulmonary artery pressure (mPAP) during right heart catheterisation (RHC) for the diagnosis. 4D flow MRI could provide non-invasive parameters to estimate the mPAP. Twenty-five patients with suspected CTEPH underwent cardiac MRI. Mean vortex duration (%), pulmonary distensibility, right ventricular volumes and function were measured using 4D flow MRI and cine sequences, and compared with the mPAP measured by RHC. The mPAP measured during RHC was 33 \u00b1 16 mmHg (10\u201366 mmHg). PH (defined as mPAP &gt; 20 mmHg) was present in 19 of 25 patients (76%). A vortical flow was observed in all but two patients (92%) on 4D flow images, and vortex duration showed good correlation with the mPAP (r = 0.805; p &lt; 0.0001). Youden index analysis showed that a vortex duration of 8.6% of the cardiac cycle provided a 95% sensitivity and an 83% specificity to detect PH. Reliability for the measurement of vortex duration was excellent for both intra-observer ICC = 0.823 and inter-observer ICC = 0.788. Vortex duration could be a useful parameter to non-invasively estimate mPAP in patients with suspected CTEPH.<\/jats:p>","DOI":"10.3390\/jcm11175237","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T20:52:51Z","timestamp":1662497571000},"page":"5237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlation between Pulmonary Artery Pressure and Vortex Duration Determined by 4D Flow MRI in Main Pulmonary Artery in Patients with Suspicion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-1929","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Deux","sequence":"first","affiliation":[{"name":"Division of Radiology, Diagnostic Department Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-1220","authenticated-orcid":false,"given":"Lindsey","family":"Crowe","sequence":"additional","affiliation":[{"name":"Division of Radiology, Diagnostic Department Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-0480","authenticated-orcid":false,"given":"L\u00e9on","family":"Genecand","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Division of Pulmonary Medicine, Department of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Division of Radiology, Diagnostic Department Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Glessgen","sequence":"additional","affiliation":[{"name":"Division of Radiology, Diagnostic Department Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-2857","authenticated-orcid":false,"given":"St\u00e9phane","family":"Noble","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Division of Cardiology, Department of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-0927","authenticated-orcid":false,"given":"Maurice","family":"Beghetti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Paediatric Cardiology Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque P\u00e9diatrique, University of Geneva and Lausanne, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ning","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA Inc., Cleveland, OH 44125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-4441","authenticated-orcid":false,"given":"Daniel","family":"Giese","sequence":"additional","affiliation":[{"name":"Magnetic Resonance, Siemens Healthcare GmbH, 91052 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lador","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Division of Pulmonary Medicine, Department of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Vall\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Radiology, Diagnostic Department Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"},{"name":"Pulmonary Hypertension Program, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"j5492","DOI":"10.1136\/bmj.j5492","article-title":"Pulmonary arterial hypertension: Pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2002828","DOI":"10.1183\/13993003.02828-2020","article-title":"ERS statement on chronic thromboembolic pulmonary hypertension","volume":"57","author":"Delcroix","year":"2021","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/14779072.2022.2034499","article-title":"Chronic thromboembolic pulmonary hypertension: A review of risk factors, management and current challenges","volume":"20","author":"Cannon","year":"2022","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_5","first-page":"100568","article-title":"Comparative accuracy of non-invasive imaging versus right heart catheterization for the diagnosis of pulmonary hypertension: A systematic review and meta-analysis","volume":"29","author":"Ulah","year":"2020","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Topyla-Putowska, W., Tomaszewski, M., Wysokinski, A., and Tomaszewski, A. (2021). Echocardiography in Pulmonary Arterial Hypertension: Comprehensive Evaluation and Technical Considerations. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153229"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1148\/radiol.2018180603","article-title":"Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models","volume":"290","author":"Johns","year":"2019","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110142","DOI":"10.1016\/j.ejrad.2021.110142","article-title":"Quantification of vortex flow in pulmonary arteries of patients with chronic thromboembolic pulmonary hypertension","volume":"148","author":"Kamada","year":"2022","journal-title":"Eur. J. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/mrm.25326","article-title":"Four-dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: Results from two institutions","volume":"73","author":"Barker","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1186\/s40064-016-2755-7","article-title":"Non-invasive evaluation of pulmonary arterial blood flow and wall shear stress in pulmonary arterial hypertension with 3D phase contrast magnetic resonance imaging","volume":"5","author":"Odari","year":"2016","journal-title":"Springerplus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2463\/mrms.rev.2021-0111","article-title":"Clinical Application of 4D Flow MR Imaging to Pulmonary Hypertension","volume":"21","author":"Ota","year":"2022","journal-title":"Magn. Reson. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1086\/685052","article-title":"Vorticity is a marker of diastolic ventricular interdependency in pulmonary hypertension","volume":"6","author":"Schafer","year":"2016","journal-title":"Pulm. Circ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.rmr.2022.03.001","article-title":"The role of cardiac magnetic resonance imaging in pulmonary arterial hypertension and chronic thrombo-embolic pulmonary hypertension","volume":"39","author":"Valentin","year":"2022","journal-title":"Rev. Mal. Respir."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/eurheartj\/ehv054","article-title":"Four-dimensional flow magnetic resonance imaging visualizes drastic change in vortex flow in the main pulmonary artery after percutaneous transluminal pulmonary angioplasty in a patient with chronic thromboembolic pulmonary hypertension","volume":"36","author":"Ota","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ramos, J.G., Fyrdahl, A., Wieslander, B., Reiter, G., Reiter, U., Jin, N., Maret, E., Eriksson, M., Caidahl, K., and Sorensson, P. (2020). Cardiovascular magnetic resonance 4D flow analysis has a higher diagnostic yield than Doppler echocardiography for detecting increased pulmonary artery pressure. BMC Med. Imaging, 20.","DOI":"10.1186\/s12880-020-00428-9"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/CIRCIMAGING.108.780247","article-title":"Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure","volume":"1","author":"Reiter","year":"2008","journal-title":"Circ. Cardiovasc. Imaging."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1148\/radiol.14140849","article-title":"Blood flow vortices along the main pulmonary artery measured with MR imaging for diagnosis of pulmonary hypertension","volume":"275","author":"Reiter","year":"2015","journal-title":"Radiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s00330-020-07287-6","article-title":"MR 4D flow-based mean pulmonary arterial pressure tracking in pulmonary hypertension","volume":"31","author":"Reiter","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Galie","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.diii.2020.09.001","article-title":"Interobserver agreement issues in radiology","volume":"101","author":"Benchoufi","year":"2020","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mri.2022.02.007","article-title":"Automated vortical blood flow-based estimation of mean pulmonary arterial pressure from 4D flow MRI","volume":"88","author":"Krauter","year":"2022","journal-title":"Magn. Reson. Imaging"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"von Spiczak, J., Crelier, G., Giese, D., Kozerke, S., Maintz, D., and Bunck, A.C. (2015). Quantitative Analysis of Vortical Blood Flow in the Thoracic Aorta Using 4D Phase Contrast MRI. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139025"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/jmri.25251","article-title":"4D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension","volume":"44","author":"Kheyfets","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Schafer, M., Barker, A.J., Kheyfets, V., Stenmark, K.R., Crapo, J., Yeager, M.E., Truong, U., Buckner, J.K., Fenster, B.E., and Hunter, K.S. (2017). Helicity and Vorticity of Pulmonary Arterial Flow in Patients with Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J. Am. Heart Assoc., 6.","DOI":"10.1161\/JAHA.117.007010"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Schafer, M., Frank, B.S., Ivy, D.D., Abman, S.H., Stenmark, K.R., Mitchell, M.B., Browne, L.P., Barker, A.J., Hunter, K.S., and Kheyfets, V. (2021). Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children with Pulmonary Arterial Hypertension. J. Am. Heart Assoc., 10.","DOI":"10.1161\/JAHA.120.020548"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/echo.12061","article-title":"The diagnostic accuracy of Doppler echocardiography in assessment of pulmonary artery systolic pressure: A meta-analysis","volume":"30","author":"Taleb","year":"2013","journal-title":"Echocardiography"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1801904","DOI":"10.1183\/13993003.01904-2018","article-title":"Diagnosis of pulmonary hypertension","volume":"53","author":"Frost","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lammers, S.R., Kao, P.H., Qi, H.J., Hunter, K., Lanning, C., Albietz, J., Hofmeister, S., Mecham, R., Stenmark, K.R., and Shandas, R. (2008). Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves. Am. J. Physiol. Heart Circ. Physiol., 295.","DOI":"10.1152\/ajpheart.00127.2008"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1088.e1","DOI":"10.1016\/j.ahj.2007.03.005","article-title":"Impaired peripheral endothelial function in severe idiopathic pulmonary hypertension correlates with the pulmonary vascular response to inhaled iloprost","volume":"153","author":"Wolff","year":"2007","journal-title":"Am. Heart J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3934\/mbe.2020031","article-title":"A computational study on the influence of aortic valve disease on hemodynamics in dilated aorta","volume":"17","author":"Xu","year":"2019","journal-title":"Math. Biosci. Eng."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12968-016-0252-3","article-title":"Age dependence of pulmonary artery blood flow measured by 4D flow cardiovascular magnetic resonance: Results of a population-based study","volume":"18","author":"Wehrum","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/mrm.28561","article-title":"Highly accelerated aortic 4D flow MRI using compressed sensing: Performance at different acceleration factors in patients with aortic disease","volume":"85","author":"Pathrose","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/mrm.28491","article-title":"Fully self-gated whole-heart 4D flow imaging from a 5-minute scan","volume":"85","author":"Pruitt","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"110035","DOI":"10.1016\/j.ejrad.2021.110035","article-title":"k-t accelerated multi-VENC 4D flow MRI improves vortex assessment in pulmonary hypertension","volume":"145","author":"Kroeger","year":"2021","journal-title":"Eur. J. Radiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5237\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:23:53Z","timestamp":1760142233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/17\/5237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":34,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11175237"],"URL":"https:\/\/doi.org\/10.3390\/jcm11175237","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]}}}