{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:23:04Z","timestamp":1790666584931,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foch foundation, foundation pour la recherche m\u00e9dicale"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Uterine transplantation is becoming an increasingly realistic therapeutic for uterine infertility. Surgical training on large animal models such as sheep is a prerequisite for establishing a program in humans. The objective of our study was to analyze the predictive factors for successful vascular anastomoses. We performed 40 autotransplants that involved end-to-side anastomoses from the uterine to the external iliac vessels. We analyzed vessel results in terms of success or failure; a total of 78.7% of arterial and 82.9% of venous anastomoses were successful in the immediate postoperative period. In multivariate analysis, independent factors associated with immediate successful vein anastomoses were as follows: a short warm ischemia time (&lt;2 h, OR = 0.05; 95% CI [0.003\u20130.88], p = 0.04), the absence of any anastomotic complications (OR = 0.06; 95% CI [0.003\u20130.099], p = 0.049), and their realization by a vascular surgeon (OR = 29.3; 95% CI [1.17\u2013731.9], p = 0.04). Secondly, we showed that an increase in lactate levels greater than 2.72 mmol\/L, six hours after reperfusion was predictive of failure, with a sensibility of 85.7% and a specificity of 75.0%. In order to perfect the management of vascular anastomoses by a vascular surgeon, training on animal models and in microsurgery are mandatory in establishing a uterine transplantation program in humans.<\/jats:p>","DOI":"10.3390\/jcm11185262","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T20:52:51Z","timestamp":1662497571000},"page":"5262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Predictive Factors for Successful Vascular Anastomoses in a Sheep Uterine Transplantation Model"],"prefix":"10.3390","volume":"11","author":[{"given":"Claire","family":"Le Gal","sequence":"first","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-1203","authenticated-orcid":false,"given":"Marie","family":"Carbonnel","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"Department of Gynecology and Obstetrics, Foch Hospital, 92150 Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Balaya","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Foch Hospital, 92150 Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-4815","authenticated-orcid":false,"given":"Christophe","family":"Richard","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"},{"name":"MIMA2 Platform, INRAE, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gelin","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"},{"name":"MIMA2 Platform, INRAE, 78350 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Galio","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sandra","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Hersant","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor University Hospital, 94000 Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bosc","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor University Hospital, 94000 Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Charton","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Amboise Pare University Hospital, AP-HP, 92100 Boulogne-Billancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-6092","authenticated-orcid":false,"given":"Pascale","family":"Chavatte-Palmer","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-2756","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Vialard","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"National Veterinary School, BREED, 94700 Maisons-Alfort, France"},{"name":"Department of Genetics, Medical Biology Laboratory, Poissy-St Germain en Laye University Hospital, 78300 Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Coscas","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Amboise Pare University Hospital, AP-HP, 92100 Boulogne-Billancourt, France"},{"name":"UMR 1018, Inserm-Paris11-CESP, Versailles Saint-Quentin-en-Yvelines University, 78000 Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Ayoubi","sequence":"additional","affiliation":[{"name":"UVSQ, INRAE, BREED, Paris-Saclay University, 78350 Jouy-en-Josas, France"},{"name":"Department of Gynecology and Obstetrics, Foch Hospital, 92150 Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/IJWH.S75635","article-title":"Uterus Transplantation: Current Progress and Future 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Scand."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5262\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:24:20Z","timestamp":1760142260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":41,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11185262"],"URL":"https:\/\/doi.org\/10.3390\/jcm11185262","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]}}}