{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:03:04Z","timestamp":1760151784844,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Fund of Japan","award":["23-A-17","26-A-4","29-A-3"],"award-info":[{"award-number":["23-A-17","26-A-4","29-A-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Some studies have shown increased risks of preterm birth, low birth weight, and cesarean delivery after oncologic treatment; others have shown the opposite. We evaluated the outcomes of pregnancies and deliveries of patients who underwent fertility-preserving surgery (FSS) for early-stage epithelial ovarian cancer (EOC) and examined their perinatal prognosis. This retrospective study included women with a history of stage IA or IC ovarian cancer reported in our previous study. The primary outcome was preterm birth after cancer diagnosis was considered. Secondary outcomes were neonatal morbidity and severe maternal morbidity. Thirty-one children were born to 25 women who had undergone FSS. The mean number of weeks at delivery was 38.7 \u00b1 0.7, and the mean birth weight of infants was 3021 \u00b1 160 g. With respect to pregnancy outcomes, 5 patients had preterm labor and 26 had full-term labor. The delivery mode was vaginal delivery in 18 patients and cesarean delivery in 13. Complications during pregnancy included placenta previa (one case) and pelvic abscess (one case). Except for three preterm infants with low birth weight, there were no other perinatal abnormalities. Pregnancy after fertility preservation in EOC has an excellent perinatal prognosis, although the cesarean delivery rate is high.<\/jats:p>","DOI":"10.3390\/jcm11185346","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T01:44:03Z","timestamp":1663033443000},"page":"5346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of Pregnancies and Deliveries of Patients Who Underwent Fertility-Preserving Surgery for Early-Stage Epithelial Ovarian Cancer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-630X","authenticated-orcid":false,"given":"Shin","family":"Nishio","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayo","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima 890-8760, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Osaka Metropolitan University, Osaka 545-8586, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Shikama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8576, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai Universit, Sayama 589-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure 737-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Tohoku University, Sendai 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-1927","authenticated-orcid":false,"given":"Kazuaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, The Jikei University, Tokyo 105-8471, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya 464-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimio","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Tohoku University, Sendai 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"ref_1","unstructured":"National Cancer Institute (2021, January 25). Surveillance, Epidemiology and End Results Program. Cancer Stat Facts: Ovarian Cancer, Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/ovary.html."},{"key":"ref_2","first-page":"1","article-title":"Births: Final Data for 2018","volume":"68","author":"Martin","year":"2019","journal-title":"Natl. Vital Stat. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/humrep\/dev288","article-title":"Assisted Reproductive Technology Use and Outcomes Among Women With a History of Cancer","volume":"31","author":"Luke","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/AOG.0000000000002102","article-title":"All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer","volume":"130","author":"Melamed","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jmig.2020.08.018","article-title":"Outcomes After Fertility-Sparing Surgery for Women With Ovarian Cancer: A Systematic Review of the Literature","volume":"28","author":"Bercow","year":"2021","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1200\/JCO.2010.31.2462","article-title":"It\u2019s Now or Never: Fertility-Related Knowledge, Decision-Making Preferences, and Treatment Intentions in Young Women With Breast Cancer-an Australian Fertility Decision Aid Collaborative Group Study","volume":"29","author":"Peate","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10549-009-0401-6","article-title":"The Fertility- Related Concerns, Needs and Preferences of Younger Women With Breast Cancer: A Systematic Review","volume":"116","author":"Peate","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1470-2045(16)00086-3","article-title":"Pregnancy After Chemotherapy in Male and Female Survivors of Childhood Cancer Treated Between 1970 and 1999: A Report From the Childhood Cancer Survivor Study Cohort","volume":"17","author":"Chow","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/humrep\/dey216","article-title":"The Impact of Cancer on Subsequent Chance of Pregnancy: A Population-Based Analysis","volume":"33","author":"Anderson","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/IGC.0b013e31827b877b","article-title":"Association Between Reproductive Cancer and Fetal Outcomes: A Population-Based Study","volume":"23","author":"Mogos","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/AOG.0000000000001035","article-title":"Adverse Obstetric Outcomes Among Early-Onset Cancer Survivors in Finland","volume":"126","author":"Melin","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/ijc.25157","article-title":"Preterm Delivery Among Female Survivors of Childhood, Adolescent and Young Adulthood Cancer","volume":"127","author":"Malila","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Haggar, F.A., Pereira, G., Preen, D., Holman, C.D., and Einarsdottir, K. (2014). Adverse Obstetric and Perinatal Outcomes Following Treatment of Adolescent and Young Adult Cancer: A Population-Based Cohort Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113292"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"van der Kooi, A.L.F., Brewster, D.H., Wood, R., Nowell, S., Fischbacher, C., van den Heuvel-Eibrink, M.M., Laven, J.S.E., Wallace, W.H.B., and Anderson, R.A. (2018). Perinatal Risks in Female Cancer Survivors: A Population-Based Analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202805"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Johansen, G., Dahm-K\u00e4hler, P., Staf, C., Fl\u00f6ter R\u00e5destad, A., and Rodriguez-Wallberg, K.A. (2020). A Swedish Nationwide prospective study of oncological and reproductive outcome following fertility-sparing surgery for treatment of early stage epithelial ovarian cancer in young women. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07511-y"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/AOG.0000000000004532","article-title":"Outcomes of the First Pregnancy After Fertility-Sparing Surgery for Early-Stage Cervical Cancer","volume":"138","author":"Nitecki","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"djx056","DOI":"10.1093\/jnci\/djx056","article-title":"Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study","volume":"109","author":"Reulen","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1200\/JCO.2009.24.8617","article-title":"Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer: A Proposal for Patient Selection","volume":"28","author":"Satoh","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/jjco\/hyv032","article-title":"A Non-randomized Confirmatory Study Regarding Selection of Fertility-Sparing Surgery for Patients With Epithelial Ovarian Cancer: Japan Clinical Oncology Group Study (JCOG1203)","volume":"45","author":"Satoh","year":"2015","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejso.2013.11.028","article-title":"Conservative Treatment of Early Stage Ovarian Cancer: Oncological and Fertility Outcomes","volume":"40","author":"Zapardiel","year":"2014","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/annonc\/mds241","article-title":"Conservative Management of Early-Stage Epithelial Ovarian Cancer: Results of a Large Retrospective Series","volume":"24","author":"Fruscio","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.fertnstert.2015.06.008","article-title":"Long-Term Follow-Up of Patients With an Isolated Ovarian Recurrence After Conservative Treatment of Epithelial Ovarian Cancer: Review of the Results of an International Multicenter Study Comprising 545 Patients","volume":"104","author":"Bentivegna","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jog.13518","article-title":"Cesarean Section Rates and Local Resources for Perinatal Care in Japan: A Nationwide Ecological Study Using the National Database of Health Insurance Claims","volume":"44","author":"Maeda","year":"2018","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1200\/JCO.2006.06.5888","article-title":"American Society of Clinical Oncology Recommendations on Fertility Preservation in Cancer Patients","volume":"24","author":"Lee","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1097\/IGC.0b013e31829e9fe2","article-title":"Association Between Reproductive Cancer and Fetal Outcomes: A Systematic Review","volume":"23","author":"Mogos","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3109\/0284186X.2012.758870","article-title":"Stillbirth, Early Death and Neonatal Morbidity Among Offspring of Female Cancer Survivors","volume":"52","author":"Dyba","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_27","first-page":"7","article-title":"Validity of Health Plan and Birth Certificate Data for Pregnancy Research. Pharmacoepidemiol","volume":"22","author":"Andrade","year":"2013","journal-title":"Drug Saf."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:29:47Z","timestamp":1760142587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":27,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11185346"],"URL":"https:\/\/doi.org\/10.3390\/jcm11185346","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,9,12]]}}}