{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:47:50Z","timestamp":1782157670158,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Project of Nanchang Science and Technology Bureau","award":["2019[258]"],"award-info":[{"award-number":["2019[258]"]}]},{"name":"General Project of Nanchang Science and Technology Bureau","award":["81660286"],"award-info":[{"award-number":["81660286"]}]},{"name":"National Natural Science Foundation","award":["2019[258]"],"award-info":[{"award-number":["2019[258]"]}]},{"name":"National Natural Science Foundation","award":["81660286"],"award-info":[{"award-number":["81660286"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty healthy controls (HCs) were recruited and underwent T1-weighted magnetic resonance imaging (MRI) scanning. After preprocessing and segmentation, individual-based MBNs were constructed based on the morphological similarity of gray matter using the combined Euclidean distance. Young survivors showed a significantly lower global clustering coefficient (p = 0.008) and local efficiency (p = 0.035) compared with HCs. In addition, ALL survivors exhibited bidirectional alterations (decreases and increases) in nodal centrality and efficiency around the Rolandic operculum and posterior occipital lobe (p &lt; 0.05, false discovery rate (FDR) corrected). Altered nodal topological efficiencies were associated with off-therapy duration and verbal memory capacity in the digit span test (p &lt; 0.05, FDR corrected). Network-based statistical analysis revealed decreased morphological connections mainly in the pallidum subnetwork, which was negatively correlated with off-therapy durations (p &lt; 0.05). Overall, the topological organization of the individual-based MBNs was disrupted in the young survivors of ALL, which may play a crucial role in executive efficiency deficits.<\/jats:p>","DOI":"10.3390\/jcm11185362","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:37:28Z","timestamp":1663108648000},"page":"5362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?\u2014Evidence from Individual-Based Morphological Brain Network Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Ying","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Oncology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, No. 90, Bayi Road, Xihu District, Nanchang 330003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-1096","authenticated-orcid":false,"given":"Long","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Peking University, No. 60 Yannan Yuan, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanchang University, Yongwaizheng St. 17, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanchang University, Yongwaizheng St. 17, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jiangxi Provincial Children\u2019s Hospital, Diezihu Ave. 1666, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jiangxi Provincial Children\u2019s Hospital, Diezihu Ave. 1666, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Spin Imaging Technology Co., Ltd., No.6 Fengxin Road, Nanjing 210012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-910X","authenticated-orcid":false,"given":"Fuqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanchang University, Yongwaizheng St. 17, Nanchang 330006, China"},{"name":"Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Yongwaizheng St. 17, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanchang University, Yongwaizheng St. 17, Nanchang 330006, China"},{"name":"Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Yongwaizheng St. 17, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Neaga, A., Jimbu, L., Mesaros, O., Bota, M., Lazar, D., Cainap, S., Blag, C., and Zdrenghea, M. 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