{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:38:24Z","timestamp":1787801904592,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Weinmann\/Germany","award":["01VSF1905"],"award-info":[{"award-number":["01VSF1905"]}]},{"name":"companies dealing with mechanical ventilation products","award":["01VSF1905"],"award-info":[{"award-number":["01VSF1905"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Non-invasive ventilation (NIV) has been shown to be the most appropriate therapy for COPD patients with chronic respiratory failure. While physiological parameters and long-term outcome frequently serve as primary outcomes, very few studies have primarily addressed the impact of NIV initiation on sleep quality in COPD. Methods: This single-center prospective cohort study comprised NIV-na\u00efve patients with COPD. All patients underwent polysomnographic evaluation both at baseline and at 3 months follow-up, accompanied by the assessment of health-related quality of life (HRQL) using the Severe Respiratory Insufficiency Questionnaire (SRI) and the Epworth Sleepiness Scale (ESS). A subgroup evaluation was performed to address the impact of comorbid obstructive sleep apnea syndrome (OSAS). Results: Forty-six patients were enrolled and twenty-five patients completed the follow-up period (66.7 \u00b1 7.4 years). NIV resulted in an increase in slow-wave sleep (+2% (\u22123.5\/7.5), p = 0.465) and rapid eye movement sleep (+2.2% (\u22121.0\/5.4), p = 0.174), although no statistical significance could be detected. ESS (\u22121.7(\u22123.6\/0.1), p = 0.066) also showed a positive trend. Significant improvements in the Respiratory Disturbance Index (RDI) (\u221212.6(\u221223.7\/\u22121.5), p = 0.027), lung function parameters, transcutaneous PCO2 and the SRI summary scale (4.5(0.9\/8), p = 0.016) were observed. Conclusion: NIV therapy does not decrease sleep quality and is even capable of improving HRQL, transcutaneous PaCO2, daytime sleepiness and RDI, and the latter especially holds true for patients with comorbid OSAS.<\/jats:p>","DOI":"10.3390\/jcm11185483","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T21:47:27Z","timestamp":1663624047000},"page":"5483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Impact of Non-Invasive Ventilation on Sleep Quality in COPD Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Maximilian","family":"Wollsching-Strobel","sequence":"first","affiliation":[{"name":"Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt K\u00f6ln, 51109 Cologne, Germany"},{"name":"Faculty of Health, School of Medicine, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Anna","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University Medical Hospital, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Julian","family":"Baur","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University Medical Hospital, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sebastian","family":"Majorski","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt K\u00f6ln, 51109 Cologne, Germany"},{"name":"Faculty of Health, School of Medicine, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike Sophie","family":"Magnet","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt K\u00f6ln, 51109 Cologne, Germany"},{"name":"Faculty of Health, School of Medicine, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Storre","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University Medical Hospital, 79110 Freiburg im Breisgau, Germany"},{"name":"Praxis Pneumologie Solln, 81477 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-2672","authenticated-orcid":false,"given":"Wolfram","family":"Windisch","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt K\u00f6ln, 51109 Cologne, Germany"},{"name":"Faculty of Health, School of Medicine, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-0211","authenticated-orcid":false,"given":"Sarah Bettina","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt K\u00f6ln, 51109 Cologne, Germany"},{"name":"Faculty of Health, School of Medicine, Witten\/Herdecke University, 58455 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1378\/chest.116.2.521","article-title":"Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease, COPD, and nocturnal hypoventilation\u2014A consensus conference report","volume":"116","author":"Goldberg","year":"1999","journal-title":"Chest"},{"key":"ref_2","first-page":"403","article-title":"The development of inpatient initiation and follow-up of home mechanical ventilation in Germany","volume":"118","author":"Schwarz","year":"2021","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/thx.2009.124263","article-title":"High-intensity versus low-intensity non-invasive ventilation in patients with stable hypercapnic COPD: A randomised crossover trial","volume":"65","author":"Dreher","year":"2010","journal-title":"Thorax"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/15412555.2017.1318843","article-title":"Why high-intensity NPPV is favourable to low-intensity NPPV: Clinical and physiological reasons","volume":"14","author":"Schwarz","year":"2017","journal-title":"COPD J. 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Care"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:34:24Z","timestamp":1760142864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/18\/5483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":29,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jcm11185483"],"URL":"https:\/\/doi.org\/10.3390\/jcm11185483","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]}}}