{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:39:34Z","timestamp":1792017574554,"version":"4.4.0"},"reference-count":44,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: When maxillary transversal expansion is needed, two protocols of treatment can be used: a maxillary orthodontic expansion followed by a classical bimaxillary osteotomy or a bimaxillary osteotomy with maxillary segmentation. The aim of this study was to assess the accuracy of segmented Le Fort I osteotomy using computer-aided orthognathic surgery and patient-specific titanium plates in patients who underwent a bimaxillary osteotomy for occlusal trouble with maxillary transversal insufficiencies. Methods: A virtual simulation of a Le Fort I osteotomy with maxillary segmentation, a sagittal split ramus osteotomy, and genioplasty (if needed) was conducted on a preoperative three-dimensional (3D) model of each patient\u2019s skull using ProPlan CMF 3.0 software (Materialise, Leuven, Belgium). Computer-assisted osteotomy saw-and-drill guides and patient-specific implants (PSIs, titanium plates) were produced and used during the surgery. We chose to focus on the maxillary repositioning accuracy by comparing the preoperative virtual surgical planning and the postoperative 3D outcome skulls using surface superimpositions and 13 standard dental and bone landmarks. Errors between these preoperative and postoperative landmarks were calculated and compared to discover if segmental maxillary repositioning using PSIs was accurate enough to be safely used to treat transversal insufficiencies. Results: A total of 22 consecutive patients\u201415 females and 7 males, with a mean age of 27.4 years\u2014who underwent bimaxillary computer-assisted orthognathic surgery with maxillary segmentation were enrolled in the study. All patients presented with occlusion trouble, 13 with Class III malocclusions (59%) and 9 (41%) with Class II malocclusions. A quantitative analysis revealed that, overall, the mean absolute discrepancies for the x-axis (transversal dimension), y-axis (anterior\u2013posterior dimensions), and z-axis (vertical dimension) were 0.59 mm, 0.74 mm, and 0.56 mm, respectively. The total error rate of maxillary repositioning was 0.62 mm between the postoperative cone-beam computed tomography (CBCT) and the preoperatively planned 3D skull. According to the literature, precision in maxilla repositioning is defined by an error rate (clinically relevant) at each landmark of &lt;2 mm and a total error of &lt;2 mm for each patient. Conclusions: A high degree of accuracy between the virtual plan and the postoperative result was observed.<\/jats:p>","DOI":"10.3390\/jcm11195495","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T22:36:44Z","timestamp":1663713404000},"page":"5495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Accuracy of Segmented Le Fort I Osteotomy with Virtual Planning in Orthognathic Surgery Using Patient-Specific Implants: A Case Series"],"prefix":"10.3390","volume":"11","author":[{"given":"Olina","family":"Rios","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillo-Facial Surgery, Head and Neck Institute, 06100 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Lerhe","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Surgery, Head and Neck Institute, 06100 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-4571","authenticated-orcid":false,"given":"Emmanuel","family":"Chamorey","sequence":"additional","affiliation":[{"name":"Department of Statistics, Antoine Lacassagne Center, 06100 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Savoldelli","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Surgery, Head and Neck Institute, 06100 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Stability of Transverse Maxillary Dental Arch Dimensions Following Orthodontic-Surgical Correction of Anterior Open Bites","volume":"13","author":"Hoppenreijs","year":"1998","journal-title":"Int. J. Adult Orthodon. Orthognath. Surg."},{"key":"ref_2","first-page":"139","article-title":"Stability of Surgical Maxillary Expansion","volume":"7","author":"Phillips","year":"1992","journal-title":"Int. J. Adult Orthodon. Orthognath. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103707","DOI":"10.1016\/j.jdent.2021.103707","article-title":"Three Dimensional Assessment of Segmented Le Fort I Osteotomy Planning and Follow-up: A Validation Study","volume":"111","author":"Vaes","year":"2021","journal-title":"J. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1746-160X-3-21","article-title":"The Hierarchy of Stability and Predictability in Orthognathic Surgery with Rigid Fixation: An Update and Extension","volume":"3","author":"Proffit","year":"2007","journal-title":"Head Face Med."},{"key":"ref_5","first-page":"191","article-title":"Orthognathic Surgery: A Hierarchy of Stability","volume":"11","author":"Proffit","year":"1996","journal-title":"Int. J. Adult Orthodon. Orthognath. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.joms.2014.10.028","article-title":"Computer-Aided Design and Computer-Aided Manufacturing Cutting Guides and Customized Titanium Plates Are Useful in Upper Maxilla Waferless Repositioning","volume":"73","author":"Mazzoni","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.joms.2006.04.001","article-title":"Clinical Feasibility of Computer-Aided Surgical Simulation (CASS) in the Treatment of Complex Cranio-Maxillofacial Deformities","volume":"65","author":"Gateno","year":"2007","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.joms.2020.04.030","article-title":"How Accurate Is 3-Dimensional Computer-Assisted Planning for Segmental Maxillary Surgery?","volume":"78","author":"Kwon","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jcms.2011.03.014","article-title":"3D Planning in Orthognathic Surgery: CAD\/CAM Surgical Splints and Prediction of the Soft and Hard Tissues Results\u2014Our Experience in 16 Cases","volume":"40","year":"2012","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.oooo.2011.11.009","article-title":"Computer-Assisted Orthognathic Surgery: Feasibility Study Using Multiple CAD\/CAM Surgical Splints","volume":"113","author":"Zinser","year":"2012","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.joms.2009.06.007","article-title":"Three-Dimensional Treatment Planning of Orthognathic Surgery in the Era of Virtual Imaging","volume":"67","author":"Swennen","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.jcms.2014.05.006","article-title":"Rapid Prototyped Patient Specific Implants for Reconstruction of Orbital Wall Defects","volume":"42","author":"Stoor","year":"2014","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.jcms.2016.09.008","article-title":"The Use of Patient-Specific Implants in Orthognathic Surgery: A Series of 32 Maxillary Osteotomy Patients","volume":"44","author":"Suojanen","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Avci, T., Omezli, M.M., and Torul, D. (2022). Investigation of the Biomechanical Stability of Cfr-PEEK in the Treatment of Mandibular Angulus Fractures by Finite Element Analysis. J. Stomatol. Oral Maxillofac. Surg., in press.","DOI":"10.1016\/j.jormas.2022.05.008"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.joms.2016.12.042","article-title":"Surgical Splint Design Influences Transverse Expansion in Segmental Maxillary Osteotomies","volume":"75","author":"Stokbro","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ying, X., Tian, K., Zhang, K., Ma, X., and Guo, H. (2021). Accuracy of Virtual Surgical Planning in Segmental Osteotomy in Combination with Bimaxillary Orthognathic Surgery with Surgery First Approach. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01892-7"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.bjoms.2016.07.007","article-title":"Splintless Surgery: Does Patient-Specific CAD-CAM Osteosynthesis Improve Accuracy of Le Fort I Osteotomy?","volume":"54","author":"Kraeima","year":"2016","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1061.e1","DOI":"10.1016\/j.joms.2016.01.016","article-title":"Custom-Machined Miniplates and Bone-Supported Guides for Orthognathic Surgery: A New Surgical Procedure","volume":"74","author":"Brunso","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.jcms.2017.06.027","article-title":"Clinical Accuracy of Waferless Maxillary Positioning Using Customized Surgical Guides and Patient Specific Osteosynthesis in Bimaxillary Orthognathic Surgery","volume":"45","author":"Heufelder","year":"2017","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.joms.2020.11.031","article-title":"Three-Dimensional Repositioning of the Maxilla in Orthognathic Surgery Using Patient-Specific Titanium Plates: A Case Series","volume":"79","author":"Greenberg","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2647.e1","DOI":"10.1016\/j.joms.2018.08.002","article-title":"Patient-Specific Printed Plates Improve Surgical Accuracy In Vitro","volume":"76","author":"Stokbro","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.joms.2014.08.024","article-title":"Cone-Beam Computed Tomographic Comparison of Surgically Assisted Rapid Palatal Expansion and Multipiece Le Fort I Osteotomy","volume":"73","author":"Yao","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2151.e1","DOI":"10.1016\/j.joms.2013.07.007","article-title":"A Paradigm Shift in Orthognathic Surgery? A Comparison of Navigation, Computer-Aided Designed\/Computer-Aided Manufactured Splints, and \u201cClassic\u201d Intermaxillary Splints to Surgical Transfer of Virtual Orthognathic Planning","volume":"71","author":"Zinser","year":"2013","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.ijom.2014.03.011","article-title":"Virtual Planning in Orthognathic Surgery","volume":"43","author":"Stokbro","year":"2014","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijom.2014.10.025","article-title":"Computer-Aided Planning in Orthognathic Surgery-Systematic Review","volume":"44","author":"Haas","year":"2014","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1016\/j.joms.2017.05.025","article-title":"A Systematic Review to Uncover a Universal Protocol for Accuracy Assessment of 3-Dimensional Virtually Planned Orthognathic Surgery","volume":"75","author":"Gaber","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/SCS.0b013e3181996803","article-title":"A Cone-Beam Computed Tomography Triple Scan Procedure to Obtain a Three-Dimensional Augmented Virtual Skull Model Appropriate for Orthognathic Surgery Planning","volume":"20","author":"Swennen","year":"2009","journal-title":"J. Craniofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajodo.2005.03.029","article-title":"Three-Dimensional Cone-Beam Computed Tomography for Assessment of Mandibular Changes after Orthognathic Surgery","volume":"131","author":"Cevidanes","year":"2007","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"40.e1","DOI":"10.1590\/2177-6709.23.6.40.e1-10.onl","article-title":"Global Distribution of Malocclusion Traits: A Systematic Review","volume":"23","author":"Alhammadi","year":"2018","journal-title":"Dent. Press J. Orthod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.sdentj.2021.09.005","article-title":"Prevalence of Malocclusion among Children of the Kingdom of Saudi Arabia\u2014A Systematic Review and Meta-Analysis","volume":"33","author":"Devanna","year":"2021","journal-title":"Saudi. Dent. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4103\/1735-3327.192269","article-title":"Prevalence of Malocclusion among Iranian Children: A Systematic Review and Meta-Analysis","volume":"13","author":"Akbari","year":"2016","journal-title":"Dent. Res. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bjps.2016.03.008","article-title":"Functional Needs of Subjects with Dentofacial Deformities: A Study Using the Index of Orthognathic Functional Treatment Need (IOFTN)","volume":"69","author":"Eslamipour","year":"2016","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Olkun, H.K., Borzabadi-Farahani, A., and U\u00e7kan, S. (2019). Orthognathic Surgery Treatment Need in a Turkish Adult Population: A Retrospective Study. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16111881"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/ams.ams_104_16","article-title":"A Retrospective Analysis of Dentofacial Deformities and Orthognathic Surgeries","volume":"7","author":"Eslamipour","year":"2017","journal-title":"Ann. Maxillofac. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"468.e1","DOI":"10.1016\/j.joms.2019.10.019","article-title":"Landmark-Based Versus Voxel-Based 3-Dimensional Quantitative Analysis of Bimaxillary Osteotomies: A Comparative Study","volume":"78","author":"Xi","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Nada, R.M., Maal, T.J.J., Breuning, K.H., Berg\u00e9, S.J., Mostafa, Y.A., and Kuijpers-Jagtman, A.M. (2011). Accuracy and Reproducibility of Voxel Based Superimposition of Cone Beam Computed Tomography Models on the Anterior Cranial Base and the Zygomatic Arches. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016520"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shahidi, S., Bahrampour, E., Soltanimehr, E., Zamani, A., Oshagh, M., Moattari, M., and Mehdizadeh, A. (2014). The Accuracy of a Designed Software for Automated Localization of Craniofacial Landmarks on CBCT Images. BMC Med. Imaging, 14.","DOI":"10.1186\/1471-2342-14-32"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s11548-015-1173-6","article-title":"A Knowledge-Based Algorithm for Automatic Detection of Cephalometric Landmarks on CBCT Images","volume":"10","author":"Gupta","year":"2015","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_39","first-page":"17","article-title":"Reeb Graph for Automatic 3D Cephalometry","volume":"8","year":"2014","journal-title":"Int. J. Image Process."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Baan, F., Liebregts, J., Xi, T., Schreurs, R., de Koning, M., Berg\u00e9, S., and Maal, T. (2016). A New 3D Tool for Assessing the Accuracy of Bimaxillary Surgery: The OrthoGnathicAnalyser. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149625"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1259\/dmfr\/17102411","article-title":"Superimposition of 3D Cone-Beam CT Models of Orthognathic Surgery Patients","volume":"34","author":"Cevidanes","year":"2005","journal-title":"Dentomaxillofac. Radiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ajodo.2005.12.008","article-title":"Image Analysis and Superimposition of 3-Dimensional Cone-Beam Computed Tomography Models","volume":"129","author":"Cevidanes","year":"2006","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Almukhtar, A., Ju, X., Khambay, B., McDonald, J., and Ayoub, A. (2014). Comparison of the Accuracy of Voxel Based Registration and Surface Based Registration for 3D Assessment of Surgical Change Following Orthognathic Surgery. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093402"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.ijom.2022.03.007","article-title":"Virtual Surgical Analysis: Long-Term Cone Beam Computed Tomography Stability Assessment of Segmental Bimaxillary Surgery","volume":"51","author":"Holte","year":"2022","journal-title":"Int. J. Oral Maxillofac. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/19\/5495\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:34:54Z","timestamp":1760142894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/19\/5495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":44,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["jcm11195495"],"URL":"https:\/\/doi.org\/10.3390\/jcm11195495","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]}}}