{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:42:27Z","timestamp":1760244147165,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82071607","32100691","XLYC1907071","151039","2018225062","202003"],"award-info":[{"award-number":["82071607","32100691","XLYC1907071","151039","2018225062","202003"]}]},{"name":"Liaoning Revitalization Talents Program","award":["82071607","32100691","XLYC1907071","151039","2018225062","202003"],"award-info":[{"award-number":["82071607","32100691","XLYC1907071","151039","2018225062","202003"]}]},{"name":"Fok Ying Tung Education Foundation","award":["82071607","32100691","XLYC1907071","151039","2018225062","202003"],"award-info":[{"award-number":["82071607","32100691","XLYC1907071","151039","2018225062","202003"]}]},{"name":"Key Research and Development Program of Liaoning Province","award":["82071607","32100691","XLYC1907071","151039","2018225062","202003"],"award-info":[{"award-number":["82071607","32100691","XLYC1907071","151039","2018225062","202003"]}]},{"name":"Outstanding Scientific Fund of Shengjing Hospital","award":["82071607","32100691","XLYC1907071","151039","2018225062","202003"],"award-info":[{"award-number":["82071607","32100691","XLYC1907071","151039","2018225062","202003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives. The objectives of this study were to identify global trends in research on cell-free deoxyribonucleic acid (cfDNA) from a bibliometric perspective and provide researchers with new research hotspots. Methods. In all, we extracted 5038 pieces of literature from PubMed and 527 articles from the Web of Science Core Collection (WoSCC) database related to cfDNA published from 1 January 2017 to 31 December 2021. For PubMed literature, we employed co-word, biclustering, and strategic diagram analysis to describe the trends in research on cfDNA in the said five years. Then, we used VOSviewer analysis for the WoSCC database to display the trends in research on cfDNA in obstetrics and gynecology during 2017\u20132021. Results. Strategy diagram analysis of 95 major Medical Subject Headings terms extracted from 5038 pieces of literature indicated that cfDNA sequence analysis for non-invasive prenatal and genetic testing and its application in the fields of neoplasm genetics and diagnosis is a newly emerging immature theme of cfDNA. VOSviewer analysis of 527 articles showed the global trends in research on cfDNA in obstetrics and gynecology, for example, in terms of most influential authors, institutions, countries, journals, and five research hotspots: (1) cfDNA application in prenatal screening and prenatal diagnosis, (2) cfDNA application in assisted reproductive technology, (3) cfDNA application in pre-eclampsia, DNA methylation, etc., (4) cfDNA application in placental dysfunction and fetal growth restriction, and (5) cfDNA application in fetal chromosomal abnormalities (fetal aneuploidy). Conclusions. Comprehensive visual analysis provides information regarding authors, organizations, countries\/regions, journals, research hotspots, and emerging topics in the field of cfDNA for obstetrics and gynecology research. This comprehensive study could make it easier to find a partner for project development and build a network of knowledge on this emerging topic.<\/jats:p>","DOI":"10.3390\/jcm11195545","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"5545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Trends in Research on Cell-Free Nucleic Acids in Obstetrics and Gynecology during 2017\u20132021"],"prefix":"10.3390","volume":"11","author":[{"given":"Wenyan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyue","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Life Sciences, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Life Sciences, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-9100","authenticated-orcid":false,"given":"Bei","family":"Shi","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China"},{"name":"Department of Physiology, School of Life Sciences, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41431-018-0132-4","article-title":"Circulating cell-free nucleic acids: Characteristics and applications","volume":"26","author":"Pos","year":"2018","journal-title":"Eur. 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