{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:51:12Z","timestamp":1770742272152,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>There are limited data on how non-infectious risk factors influence tubal patency in women with subfertility. With hormonal shifts influencing tubal secretions, it has been argued that subfertile women with polycystic ovary syndrome (PCOS) have lower tubal patency. In a retrospective study, 216 women, who underwent diagnostic evaluation for PCOS and infertility, were included. Fallopian tube patency was tested using HSG, HyCoSy, and laparoscopic chromopertubation in 171 (79.2%), 28 (13.0%), and 17 (7.9%), respectively. Bilateral patency was found in 193 women (89.4%), unilateral patency in 13 (6.0%) and bilateral occlusion in 10 (4.6%) patients. Women with PCOS phenotypes C (odds ratio, OR 0.179, 95% CI: 0.039\u20130.828) and D (OR 0.256, 95% CI: 0.069\u20130.947) demonstrated lower risks for Fallopian tube occlusion. In conclusion, our data suggest that about 5% of infertile women with PCOS also have bilateral tubal occlusion, which seems similar to the rate in non-subfertile women. With 11% of participants having unilateral or bilateral tubal occlusion, this should reassure women with PCOS that their hormonal challenges do not seem to increase their risk for tubal factor subfertility.<\/jats:p>","DOI":"10.3390\/jcm11195610","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T01:41:58Z","timestamp":1664156518000},"page":"5610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Prevalence of Fallopian Tube Occlusion in Women with Polycystic Ovary Syndrome Seems Similar to Non-Subfertile Women: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Stefan","family":"Ghobrial","sequence":"first","affiliation":[{"name":"Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Preston","family":"Parry","sequence":"additional","affiliation":[{"name":"Parryscope and Positive Steps Fertility, Madison, WI 39110, USA"},{"name":"Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Holzer","sequence":"additional","affiliation":[{"name":"Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Aschauer","sequence":"additional","affiliation":[{"name":"Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Selzer","sequence":"additional","affiliation":[{"name":"Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Brezina","sequence":"additional","affiliation":[{"name":"Privatklinik Goldenes Kreuz, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Helmy-Bader","sequence":"additional","affiliation":[{"name":"Clinical Division of General Gynecology and Gynecologic Oncology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[{"name":"Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/AOG.0000000000002698","article-title":"Polycystic Ovary Syndrome","volume":"132","author":"Azziz","year":"2018","journal-title":"Obs. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.fertnstert.2013.03.015","article-title":"The basic fertility workup in women with polycystic ovary syndrome: A systematic review","volume":"100","author":"Nahuis","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1001\/jama.2017.7217","article-title":"Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial","volume":"317","author":"Wu","year":"2017","journal-title":"J. Am. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.fertnstert.2018.11.030","article-title":"A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome","volume":"111","author":"Mejia","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/jog.12996","article-title":"Clomiphene citrate before and after withdrawal bleeding for induction of ovulation in women with polycystic ovary syndrome: Randomized cross-over trial","volume":"42","author":"Elbohoty","year":"2016","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0015-0282(02)04843-4","article-title":"Effect of rosiglitazone on spontaneous and clomiphene citrate-induced ovulation in women with polycystic ovary syndrome","volume":"79","author":"Ghazeeri","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJMoa1313517","article-title":"Letrozole versus clomiphene for infertility in the polycystic ovary syndrome","volume":"371","author":"Legro","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.fertnstert.2013.08.056","article-title":"The Pregnancy in Polycystic Ovary Syndrome II study: Baseline characteristics and effects of obesity from a multicenter randomized clinical trial","volume":"101","author":"Legro","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.fertnstert.2006.03.037","article-title":"The Pregnancy in Polycystic Ovary Syndrome study: Baseline characteristics of the randomized cohort including racial effects","volume":"86","author":"Legro","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMoa063971","article-title":"Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome","volume":"356","author":"Legro","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/ijgo.13375","article-title":"Letrozole versus clomiphene citrate for ovulation induction in anovulatory women with polycystic ovarian syndrome: A randomized controlled trial","volume":"152","author":"Bansal","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.fertnstert.2006.06.050","article-title":"Utility of screening for other causes of infertility in women with \u201cknown\u201d polycystic ovary syndrome","volume":"87","author":"McGovern","year":"2007","journal-title":"Fertil. Steril."},{"key":"ref_14","first-page":"551","article-title":"Hysterosalpingographic evaluation of tubal patency in women treated for anovulatory infertility","volume":"64","author":"Kotarski","year":"1993","journal-title":"Ginekol. Pol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril., 81, 19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.fertnstert.2004.12.050","article-title":"Hysterosalpingography","volume":"83","author":"Baramki","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00404-014-3465-4","article-title":"Hysterosalpingo contrast sonography (HyCoSy): Let\u2019s make the point!","volume":"291","author":"Capobianco","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jmig.2019.03.006","article-title":"Assessment of Tubal Patency: A Prospective Comparison of Diagnostic Hysteroscopy and Laparoscopic Chromopertubation","volume":"27","author":"Ott","year":"2020","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/humupd\/dmt061","article-title":"Definition and significance of polycystic ovarian morphology: A task force report from the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13048-019-0564-7","article-title":"Changes in serum markers of patients with PCOS during consecutive clomiphene stimulation cycles: A retrospective study","volume":"12","author":"Hager","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"904706","DOI":"10.3389\/fendo.2022.904706","article-title":"Polycystic Ovary Syndrome Phenotype D Versus Functional Hypothalamic Amenorrhea with Polycystic Ovarian Morphology: A Retrospective Study About a Frequent Differential Diagnosis","volume":"13","author":"Beitl","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Holzer, I., Parry, J.P., Beitl, K., Pozderovic, B., Marculescu, R., and Ott, J. (2022). Parameters for Calcium Metabolism in Women with Polycystic Ovary Syndrome Who Undergo Stimulation with Letrozole: A Prospective Cohort Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092597"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1210\/jc.2014-2523","article-title":"Testosterone to dihydrotestosterone ratio as a new biomarker for an adverse metabolic phenotype in the polycystic ovary syndrome","volume":"100","author":"Hofer","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1007\/s43032-021-00535-0","article-title":"Evaluation of the Efficacy of Sex Hormone-Binding Globulin in Insulin Resistance Assessment Based on HOMA-IR in Patients with PCOS","volume":"28","author":"Chen","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.31083\/j.ceog4903070","article-title":"Fallopian tube patency diagnosed by laparoscopic chromopertubation in women with polycystic ovarian syndrome and non-subfertile controls: A retrospective case-control study","volume":"49","author":"Mayrhofer","year":"2022","journal-title":"Clin. Exp. Obs. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1056\/NEJMoa1505297","article-title":"Randomized Trial of a Lifestyle Program in Obese Infertile Women","volume":"374","author":"Mutsaerts","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e18383","DOI":"10.1097\/MD.0000000000018383","article-title":"Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study","volume":"99","author":"Shi","year":"2020","journal-title":"Medicine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/humrep\/dex227","article-title":"Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome","volume":"32","author":"Amer","year":"2017","journal-title":"Hum. Reprododuction"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.fertnstert.2020.06.002","article-title":"Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction","volume":"114","author":"Vitek","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1080\/09513590.2017.1332174","article-title":"Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: A prospective randomized trial","volume":"33","author":"Liu","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12020-020-02315-3","article-title":"The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: A double blind, randomized clinical trial","volume":"69","author":"Rasheedy","year":"2020","journal-title":"Endocrine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1093\/humrep\/dew175","article-title":"Fertility-related quality of life from two RCT cohorts with infertility: Unexplained infertility and polycystic ovary syndrome","volume":"31","author":"Santoro","year":"2016","journal-title":"Hum. Reprododuction"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1093\/humrep\/deaa157","article-title":"Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating","volume":"35","author":"Colina","year":"2020","journal-title":"Hum. Reprododuction"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/mrd.23291","article-title":"How do elevated levels of testosterone affect the function of the human fallopian tube and fertility? New insights","volume":"87","author":"Dulohery","year":"2020","journal-title":"Mol. Reprod. Dev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hager, M., Wenzl, R., Riesenhuber, S., Marschalek, J., Kuessel, L., Mayrhofer, D., Ristl, R., Kurz, C., and Ott, J. (2019). The Prevalence of Incidental Endometriosis in Women Undergoing Laparoscopic Ovarian Drilling for Clomiphene-Resistant Polycystic Ovary Syndrome: A Retrospective Cohort Study and Meta-Analysis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081210"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/oxfordjournals.humrep.a138238","article-title":"The multicenter transcervical balloon tubaplasty study: Conclusions and comparison to alternative technologies","volume":"8","author":"Gleicher","year":"1993","journal-title":"Hum. Reprododuction"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/19\/5610\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:26Z","timestamp":1760143106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/19\/5610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":36,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["jcm11195610"],"URL":"https:\/\/doi.org\/10.3390\/jcm11195610","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]}}}