{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:06:02Z","timestamp":1794027962629,"version":"4.8.0"},"reference-count":71,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI20\/00592"],"award-info":[{"award-number":["PI20\/00592"]}]},{"name":"Instituto de Salud Carlos III","award":["FI21\/00007"],"award-info":[{"award-number":["FI21\/00007"]}]},{"name":"European Regional Development Fund (ERDF)","award":["PI20\/00592"],"award-info":[{"award-number":["PI20\/00592"]}]},{"name":"European Regional Development Fund (ERDF)","award":["FI21\/00007"],"award-info":[{"award-number":["FI21\/00007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim was to describe three patients with hemorrhagic hereditary telangiectasia (HHT) requiring liver transplantation (LT) and to perform a systematic review focusing on surgical complications and long-term follow-up. Unrestricted searches of the Medline and Embase databases were performed through February 2022. Forty-five studies were selected including 80 patients plus the three new reported patients, 68 (81.9%) were female and mean age was 50 (27\u201372) years. Main indications for LT were high-output cardiac failure (n = 40; 48.2%), ischemic cholangitis (n = 19; 22.9%), and a combination of both conditions (n = 13;15.6%). Mean cold ischemic time and red blood cell units transfused during LT were 554 (300\u2013941) minutes and 11.4 (0\u201388) units, respectively. Complications within 30 days were described in 28 (33.7%) patients, mainly bleeding complications in 13 patients, hepatic artery (HA) thrombosis in four and hepatic vein thrombosis in one. Mean follow-up was 76.4 (1\u2013288) months, and during it, four new patients developed thrombotic complications in HA, HA aneurysm, celiac artery, and the portal\u2013splenic\u2013mesenteric vein. HHT relapse in the transplant allograft was detected in 13 (17.1%) patients after 1\u201319 years (including two fatal recurrences). Overall mortality was 12%. In conclusion, previous assessment of HA anatomy and hyperdynamic circulatory state could reduce LT complications. The risk of relapse in the hepatic graft supports a multidisciplinary follow-up for HHT patients with LT.<\/jats:p>","DOI":"10.3390\/jcm11195624","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T01:41:58Z","timestamp":1664156518000},"page":"5624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Perioperative Complications and Long-Term Follow-Up of Liver Transplantation in Hemorrhagic Hereditary Telangiectasia: Report of Three Cases and Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-804X","authenticated-orcid":false,"given":"Antoni","family":"Riera-Mestre","sequence":"first","affiliation":[{"name":"Hemorrhagic Hereditary Telangiectasia Unit, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Internal Medicine Department, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-6260","authenticated-orcid":false,"given":"Pau","family":"Cerd\u00e0","sequence":"additional","affiliation":[{"name":"Hemorrhagic Hereditary Telangiectasia Unit, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Internal Medicine Department, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoelimar Carolina","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery, Institut Cl\u00ednic de Malalties Digestives i Metab\u00f2liques, Hospital Cl\u00ednic, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Iriarte","sequence":"additional","affiliation":[{"name":"Hemorrhagic Hereditary Telangiectasia Unit, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Internal Medicine Department, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Torroella","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery, Institut Cl\u00ednic de Malalties Digestives i Metab\u00f2liques, Hospital Cl\u00ednic, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-2389","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Mora-Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Hemorrhagic Hereditary Telangiectasia Unit, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Internal Medicine Department, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castellote","sequence":"additional","affiliation":[{"name":"Hemorrhagic Hereditary Telangiectasia Unit, Hospital Universitari Bellvitge, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Liver Transplant Unit, Gastroenterology Department, Hospital Universitari Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-5051","authenticated-orcid":false,"given":"Amelia","family":"Hessheimer","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery, Institut Cl\u00ednic de Malalties Digestives i Metab\u00f2liques, Hospital Cl\u00ednic, 08036 Barcelona, Spain"},{"name":"Hepatopancreatobiliary Surgery & Transplantation, General & Digestive Surgery, Hospital Universitario La Paz, IdiPAZ, CIBERehd, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-6824","authenticated-orcid":false,"given":"Constantino","family":"Fondevila","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery, Institut Cl\u00ednic de Malalties Digestives i Metab\u00f2liques, Hospital Cl\u00ednic, 08036 Barcelona, Spain"},{"name":"Hepatopancreatobiliary Surgery & Transplantation, General & Digestive Surgery, Hospital Universitario La Paz, IdiPAZ, CIBERehd, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Llad\u00f3","sequence":"additional","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL), L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"},{"name":"Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain"},{"name":"Liver Transplant Unit, Surgery Department, Hospital Universitari Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","article-title":"Diagnostic criteria for hereditary hemorrhagic 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