{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:38:08Z","timestamp":1792406288147,"version":"4.4.0"},"reference-count":21,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007642","name":"University of Rome \u201cTor Vergata\u201d","doi-asserted-by":"publisher","award":["E83C22001960005"],"award-info":[{"award-number":["E83C22001960005"]}],"id":[{"id":"10.13039\/501100007642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The incidence of hair loss (HL) and telogen effluvium (TE) has increased due to the spread of the coronavirus disease (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). New biotechnologies based on micro-needling (MND) with Low-Level LED Therapy (LLLT) and Growth Factors (GFs) used for hair re-growth (HR-G) in Androgenetic Alopecia (AGA) need to be standardized also in HL and TE related to COVID-19. This article aims to describe the preliminary clinical results obtained from an open-label case-series observational study. MND with LLLT and GFs was used in patients affected by HL and TE-related to COVID-19. In total, 10 patients (6 men were identified in stage I\u2013III vertex according to the Norwood\u2013Hamilton scale, and 4 women were identified in stage I\u2013II according to the Ludwig scale) were enrolled and analyzed after screening (exclusion and inclusion criteria evaluation). HR-G assessment was analyzed through photography, physician\u2019s and patient\u2019s global assessment scale, and standardized phototrichograms during a short follow-up: T0\u2014baseline; T1\u201420 weeks (wks). In the targeted area computerized trichograms showed encouraging results with a hair density increase of 11 \u00b1 2 hairs\/cm2 at T1 after 20 wks (20 wks vs. 0 wks) compared with baseline (58 \u00b1 2 hairs\/cm2 at T1 versus 47 \u00b1 2 hairs\/cm2 at baseline) with a not quite statistically significant difference in HR-G (p = 0.0690). The preliminary effectiveness of MND with LLLT and GFs use has been demonstrated in mild-to-moderate HL and TE related to COVID-19. Further controlled trials are required to confirm these preliminary results.<\/jats:p>","DOI":"10.3390\/jcm11195760","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"5760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preliminary Investigation on Micro-Needling with Low-Level LED Therapy and Growth Factors in Hair Loss Related to COVID-19"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-3977","authenticated-orcid":false,"given":"Pietro","family":"Gentile","sequence":"first","affiliation":[{"name":"Plastic and Reconstructive Surgery, Department of Surgical Science, University of \u201cTor Vergata\u201d, 00133 Rome, Italy"},{"name":"Academy of International Regenerative Medicine & Surgery Societies (AIRMESS), 1201 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","first-page":"56406","article-title":"Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia","volume":"131","author":"Gentile","year":"2018","journal-title":"J. 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