{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:57:46Z","timestamp":1784289466056,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospices Civils de Lyon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Spinal anaesthesia is an established component of perioperative management for fast-track lower limbs arthroplasty. Short-acting local anaesthetics may present an interesting option for primary non-complicated knee (TKA) and hip (THA) arthroplasty. We describe the perioperative outcomes in patients operated under fixed 50 mg spinal chloroprocaine for total hip and knee replacement. In this retrospective case series study, 65 patients were analysed (median age 65 years, 55% females, benefit from THA (n = 31), TKA (n = 25), and unicompartmental knee arthroplasty (n = 9)). In all cases, anaesthesia duration (87 min) was sufficient for successful surgery (52 min). Up to 45% of patients (THA and less in TKA) developed postoperative pain in the post-anaesthesia care unit (PACU), requiring intravenous morphine titration (up to 7.5 mg). One patient developed severe breakthrough pain requiring advanced regional analgesia. The median PACU stay was up to 97 min (less in TKA), and the incidence of nausea and urinary retention was low. All patients were able to start physical therapy on the same day of surgery. These findings encourage the use of a short-acting agent for spinal anaesthesia in patients with primary non-complicated arthroplasty; however, the relay analgesia should be systematically implemented to avoid breakthrough pain in PACU.<\/jats:p>","DOI":"10.3390\/jcm11195771","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"5771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Perioperative Outcomes in Patients Who Received Spinal Chloroprocaine for Total Hip or Knee Arthroplasty\u2014Consecutive Case Series Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Khaleifah","family":"Alhefeiti","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, F-69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Patrascu","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, F-69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lustig","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Orthop\u00e9dique et M\u00e9decine de Sport, Centre d\u2019Excellence FIFA H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, F-69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Aubrun","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, F-69004 Lyon, France"},{"name":"U1290 RESHAPE, INSERM, Universit\u00e9 Claude Bernard Lyon 1, F-69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-2171","authenticated-orcid":false,"given":"Mikhail","family":"Dziadzko","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Universit\u00e9 Claude Bernard, F-69004 Lyon, France"},{"name":"U1290 RESHAPE, INSERM, Universit\u00e9 Claude Bernard Lyon 1, F-69003 Lyon, France"},{"name":"Consultation Douleur, Groupement Hospitalier Nord, Hospices Civils de Lyon, F-69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/ACO.0000000000001170","article-title":"Regional versus general anesthesia for ambulatory total hip and knee arthroplasty","volume":"5","author":"Baratta","year":"2022","journal-title":"Curr. 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