{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:59:36Z","timestamp":1781765976120,"version":"3.54.5"},"reference-count":64,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The number of pregnancies achieved using in vitro fertilization (IVF) is rapidly increasing around the world. The chance of obtaining a successful pregnancy is also significantly improved due to technological advances and improvement in infertility treatment. Despite this success, there is evidence that pregnancy conceived by IVF has an increased risk of adverse maternal and perinatal outcome mainly represented by the development of hypertensive diseases, pre-eclampsia, and fetal growth restriction. Although different cofactors may play a role in the genesis of these diseases, the development of the placenta has a pivotal function in determining pregnancy outcomes. Advances in ultrasound technology already allows for evaluation in the first trimester, the impedance to flow in the uterine artery, and the placental volume using Doppler and three-dimensional techniques. This review article aims to describe the modification occurring in placental volume and hemodynamics after IVF and to summarize the differences present according to the type of IVF (fresh vs. frozen-thawed embryos).<\/jats:p>","DOI":"10.3390\/jcm11195793","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"5793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Placental Volume and Uterine Artery Doppler in Pregnancy Following In Vitro Fertilization: A Comprehensive Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-596X","authenticated-orcid":false,"given":"Serena","family":"Resta","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Scandella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Mappa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Pietrolucci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavjola","family":"Maqina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Universit\u00e0 di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/humrep\/dew082","article-title":"International Committee for Monitoring Assisted Reproductive Technologies World Report: Assisted Reproductive Technology 2008, 2009 and 2010","volume":"31","author":"Dyer","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_2","unstructured":"(2022, September 16). Ministero Della Salute: Procreazione Medicalmente Assistita, Available online: https:\/\/www.salute.gov.it\/portale\/donna\/dettaglioContenutiDonna.jsp?lingua=italiano&id=4570&area=Salute%20donna&menu=nascita."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.rbmo.2018.12.023","article-title":"Placental volume and other first-trimester outcomes: Are there differences between fresh embryo transfer, frozen-thawed embryo transfer and natural conception?","volume":"38","author":"Choux","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal outcomes in singletons following in vitro fertilization: A meta-analysis","volume":"103","author":"Jackson","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejogrb.2009.05.035","article-title":"Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta-analyses","volume":"146","author":"McDonald","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/humrep\/dez079","article-title":"Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus","volume":"34","author":"Saito","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/jhh.2012.13","article-title":"Assisted reproductive technology and pregnancy-related hypertensive complications: A systematic review","volume":"27","author":"Thomopoulos","year":"2013","journal-title":"J. Hum. Hypertens."},{"key":"ref_8","first-page":"CD011184","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"3","author":"Wong","year":"2017","journal-title":"Cochrane Libr. Cochrane Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.fertnstert.2012.05.019","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: A systematic review and meta-analysis","volume":"98","author":"Maheshwari","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0140-6736(07)60456-5","article-title":"Outcome of assisted reproduction","volume":"370","author":"Sutcliffe","year":"2007","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humupd\/dmt041","article-title":"The periconceptional period, reproduction and long-term health of offspring: The importance of one-carbon metabolism","volume":"19","author":"Twigt","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13148-015-0120-2","article-title":"The placenta: Phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy","volume":"7","author":"Choux","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/humupd\/dmq017","article-title":"Clinical and immunologic aspects of egg donation pregnancies: A systematic review","volume":"16","author":"Lashley","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.placenta.2013.11.015","article-title":"Association between first-trimester placental volume and birth weight","volume":"35","author":"Effendi","year":"2014","journal-title":"Placenta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/pd.4692","article-title":"First trimester placental volume and vascular indices in pregnancies complicated by preeclampsia","volume":"35","author":"Plasencia","year":"2015","journal-title":"Prenat. Diagn."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/humupd\/dmy030","article-title":"Placental formation in early pregnancy: How is the centre of the placenta made?","volume":"24","author":"Boss","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bpobgyn.2011.02.005","article-title":"Placental bed & maternal\u2014Fetal disorders. Preface","volume":"25","author":"Brosens","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"dev163428","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jama.2010.102","article-title":"First-trimester determination of complications of late pregnancy","volume":"303","author":"Smith","year":"2010","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/aogs.13259","article-title":"Placental development and function in women with a history of placenta-related complications: A systematic review","volume":"97","author":"Reijnders","year":"2018","journal-title":"Acta Obstet. Et Gynecol. Scand."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dms018","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: A systematic review and meta-analysis","volume":"18","author":"Pandey","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists Committee on Obstetric Practice Society for Maternal-Fetal Medicine (2016). Committee opinion no 671: Perinatal risks associated with assisted reproductive technology. Obstet. Gynecol., 128, e61\u2013e68.","DOI":"10.1097\/AOG.0000000000001643"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/AOG.0000000000002786","article-title":"Maternal and fetal risk associated with assisted reproductive technology","volume":"132","author":"Kawwass","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.fertnstert.2017.09.014","article-title":"Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: A model to evaluate IVF treatment versus maternal effects","volume":"108","author":"Woo","year":"2017","journal-title":"Fertil. Steri."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12958-016-0211-8","article-title":"Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: A comprehensive systematic review","volume":"14","author":"Palomba","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/1471-0528.14269","article-title":"Pregnancy at very advanced maternal age: A UK population-based cohort study","volume":"124","author":"Fitzpatrick","year":"2017","journal-title":"BJOG"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.rbmo.2012.03.017","article-title":"Placental adaptations to the maternal-fetal environment: Implications for fetal growth and developmental programming","volume":"25","author":"Sandovici","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fertnstert.2015.09.007","article-title":"Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancyoutcomes in singleton pregnancies: A meta-analysis of cohort studies","volume":"105","author":"Qin","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.fertnstert.2011.05.050","article-title":"Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: A prospective rando\u2014Mized trial comparing fresh and frozen-thawed embryo transfer in normal responders","volume":"96","author":"Shapiro","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12958-021-00869-z","article-title":"The impact of endometrial preparation for frozen embryo transfer on maternal and neonatal outcomes: A review","volume":"20","author":"Lee","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.fertnstert.2010.05.049","article-title":"Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer","volume":"95","author":"Ratcliffe","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humrep\/det440","article-title":"Large baby syndrome in singletons born after frozen embryo transfer (FET): Is it due to maternal factors or the cryotechnique?","volume":"29","author":"Pinborg","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humupd\/dmx031","article-title":"Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer?","volume":"24","author":"Maheshwari","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humupd\/dmy033","article-title":"Fresh versus elective frozen embryo transfer in IVF\/ICSI cycles: A systematic review and meta-analysis of reproductive outcomes","volume":"25","author":"Roque","year":"2019","journal-title":"Hum. Reprod. Update."},{"key":"ref_38","first-page":"CD003414","article-title":"Cycle regimens for frozen-thawed embryo transfer","volume":"7","author":"Ghobara","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"126.e1","DOI":"10.1016\/j.ajog.2019.03.010","article-title":"Neonatal and maternal outcome after frozen embryotransfer: Increased risks in programmed cycles","volume":"221","author":"Wennerholm","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_40","first-page":"R69","article-title":"Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductivetechnologies","volume":"304","author":"Conrad","year":"2013","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum","volume":"73","author":"Schaub","year":"2019","journal-title":"Hypertension"},{"key":"ref_42","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: Systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Hum. Reprod. Update."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/humrep\/dez095","article-title":"Perinatal outcomes of singletons following vitrification versus slow-freezing of embryos: A multicenter cohort study using propensity score analysis","volume":"34","author":"Gu","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_44","first-page":"569","article-title":"The \u2018Great Obstetrical Syndromes\u2019 are associated with disorders of deep placentation","volume":"25","author":"Brosens","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1080\/14767058.2020.1767060","article-title":"Modeling Pulsatility Index nomograms from different maternal and fetal vessels by quantile regression at 24\u201340 weeks of gestation: A prospective cross-sectional study","volume":"35","author":"Rizzo","year":"2022","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/uog.5157","article-title":"Uterine artery Doppler at 11+0 to 13+6 weeks in the prediction of pre-eclampsia","volume":"30","author":"Plasencia","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/uog.13275","article-title":"First-trimester uterine artery Doppler and adverse pregnancy outcome: A meta-analysis involving 55974 women","volume":"43","author":"Velauthar","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejogrb.2007.08.015","article-title":"First trimester uterine Doppler and three-dimensional ultrasound placental volume calculation in predicting preeclampsia","volume":"138","author":"Rizzo","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/humrep\/der117","article-title":"Assisted conception and placental perfusion assessed by uterine artery Doppler at 11\u201313 weeks\u2019 gestation","volume":"26","author":"Carbone","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/uog.3842","article-title":"Uterine artery Doppler velocimetry at 11\u201314 weeks in singleton pregnancies conceived by assisted reproductive technology","volume":"29","author":"Prefumo","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1177\/1933719116641765","article-title":"Are There Differences in Placental Volume and Uterine Artery Doppler in Pregnancies Resulting From the Transfer of Fresh Versus Frozen-Thawed Embryos Through In Vitro Fertilization","volume":"23","author":"Rizzo","year":"2016","journal-title":"Reprod. Sci"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1093\/humrep\/deu241","article-title":"Altered gene expression in human placentas after IVF\/ICSI","volume":"29","author":"Nelissen","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fertnstert.2008.12.144","article-title":"Placental pathology in egg donor pregnancies","volume":"93","author":"Gundogan","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/uog.21969","article-title":"Uterine artery Doppler in singleton pregnancies conceived after in-vitro fertilization or intracytoplasmic sperm injection with fresh vs. frozen blastocyst transfer: Longitudinal cohort study","volume":"56","author":"Cavoretto","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/humrep\/deab070","article-title":"The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: The Rotterdam Periconception cohort","volume":"36","author":"Rousian","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/uog.19197","article-title":"Correlation between central and uterine hemodynamics in hypertensive disorders of pregnancy","volume":"54","author":"Perry","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/uog.14633","article-title":"Prediction of early- and late- onset pregnancy-induced hypertension using placental volume on three-dimensional ultrasound and uterine artery Doppler","volume":"45","author":"Arakaki","year":"2015","journal-title":"Ultrasound Obstet. Gyneco."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1046\/j.0960-7692.2001.00596.x","article-title":"Uterine artery Doppler and placental volume in the first trimester in the prediction of pregnancy complications","volume":"18","author":"Schuchter","year":"2001","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/pd.5356","article-title":"Placental volume at 11 to 14 gestational weeks in pregnancies complicated with fetal growth restriction and preeclampsia","volume":"38","author":"Papastefanou","year":"2018","journal-title":"Prenat. Diagn."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/humrep\/deu273","article-title":"First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF\/ICSI pregnancies","volume":"29","author":"Rifouna","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/uog.14918","article-title":"Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks\u2019 gestation in pregnancies conceived with in-vitro fertilization: Comparison between autologous and donor oocyte recipients","volume":"47","author":"Rizzo","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.fertnstert.2017.04.010","article-title":"Mode of conception does not appear to affect placental volume in the first trimester","volume":"107","author":"Churchill","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10815-018-1176-7","article-title":"Mode of conception does not affect fetal or placental growth parameters or ratios in early gestation or at delivery","volume":"35","author":"Sundheimer","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Manna, C., Lacconi, V., Rizzo, G., De Lorenzo, A., and Massimiani, M. (2022). Placental Dysfunction in Assisted Reproductive Pregnancies: Perinatal, Neonatal and Adult Life Outcomes. Int. J. Mol. 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