{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:52:48Z","timestamp":1783155168961,"version":"3.54.6"},"reference-count":40,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Epilepsy surgery in low-grade epilepsy-associated neuroepithelial tumors (LEAT) is usually evaluated in drug-resistant cases, often meaning a time delay from diagnosis to surgery. To identify factors predicting good postoperative seizure control and neuropsychological outcome, the cohort of LEAT patients treated with resective epilepsy surgery at the Epilepsy Center Frankfurt Rhine-Main, Germany between 2015 and 2020 was analyzed. Thirty-five patients (19 males (54.3%) and 16 females, aged 4 to 40 years (M = 18.1), mean follow-up 33 months) were included. Following surgery, 77.1% of patients remained seizure-free (Engel IA\/ILAE 1). Hippocampus and amygdala resection was predictive for seizure freedom in temporal lobe epilepsy. In total, 65.7% of all patients showed cognitive deficits during presurgical workup, decreasing to 51.4% after surgery, predominantly due to significantly less impaired memory functions (p = 0.011). Patients with presurgical cognitive deficits showed a tendency toward a longer duration of epilepsy (p = 0.050). Focal to bilateral tonic-clonic seizures (p = 0.019) and young age at onset (p = 0.018) were associated with a higher likelihood of cognitive deficits after surgery. Therefore, we advocate early epilepsy surgery without requiring proof of drug-resistance. This refers especially to lesions associated with the non-eloquent cortex.<\/jats:p>","DOI":"10.3390\/jcm11195892","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T23:39:31Z","timestamp":1665272371000},"page":"5892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Early Epilepsy Surgery in Benign Cerebral Tumors: Avoid Your \u2018Low-Grade\u2019 Becoming a \u2018Long-Term\u2019 Epilepsy-Associated Tumor"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-2631","authenticated-orcid":false,"given":"Catrin","family":"Mann","sequence":"first","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-5452","authenticated-orcid":false,"given":"Nadine","family":"Conradi","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-0169","authenticated-orcid":false,"given":"Elisabeth","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Institute for Neuroradiology, University Hospital Frankfurt, Goethe University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-7806","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Konczalla","sequence":"additional","affiliation":[{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Department of Neurosurgery, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-2829","authenticated-orcid":false,"given":"Thomas M.","family":"Freiman","sequence":"additional","affiliation":[{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Department of Neurosurgery, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Department of Neurosurgery, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Spyrantis","sequence":"additional","affiliation":[{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Department of Neurosurgery, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Weber","sequence":"additional","affiliation":[{"name":"Neurological Institute (Edinger Institute), University Hospital Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"University Cancer Center (UCT), University Hospital Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Frankfurt Cancer Institute (FCI), 60528 Frankfurt am Main, Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Frankfurt\/Mainz and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Harter","sequence":"additional","affiliation":[{"name":"Neurological Institute (Edinger Institute), University Hospital Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"University Cancer Center (UCT), University Hospital Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Frankfurt Cancer Institute (FCI), 60528 Frankfurt am Main, Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Frankfurt\/Mainz and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-7471","authenticated-orcid":false,"given":"Felix","family":"Rosenow","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schubert-Bast","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"},{"name":"Department of Child Neurology, University Hospital Frankfurt, Goethe-University Frankfurt, 60528 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"Histopathological Findings in Brain Tissue Obtained during Epilepsy 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