{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:26:39Z","timestamp":1790882799001,"version":"4.1.0"},"reference-count":12,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mechanical ventilation is a cornerstone in the treatment of critical illness, especially sepsis. Prolonged mechanical ventilation, for a duration exceeding 21 days, is associated with higher rates of in-hospital and post-discharge mortality. Our aim was to assess the association between in-hospital ventilation duration and long-term life expectancy in patients ventilated in intensive care units specifically due to sepsis of any origin. We conducted a population-based retrospective cohort study of adults hospitalized in a general intensive care unit for 24 h or more during 2007\u20132017, who were diagnosed with sepsis or septic shock, treated with invasive mechanical ventilation for a maximum of 60 days and survived hospitalization. The primary exposure was the length of invasive mechanical ventilation. In an adjusted multivariable regression model, survival rates at 1, 2, 3 and 4 years post-hospitalization did not differ significantly between patients who were ventilated for 3\u20138 days (n = 169), 9\u201321 days (n = 160) or 22\u201360 days (n = 170), and those who were ventilated for 1\u20132 days (n = 192). We concluded that the duration of in-hospital ventilation in patients with sepsis cannot serve as a predictor for long-term survival. Thus, the duration of ventilation in itself should not guide the level of care in ventilated patients with sepsis.<\/jats:p>","DOI":"10.3390\/jcm11205995","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T22:18:13Z","timestamp":1665526693000},"page":"5995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can the Duration of In-Hospital Ventilation in Patients with Sepsis Help Predict Long-Term Survival?"],"prefix":"10.3390","volume":"11","author":[{"given":"Moti","family":"Klein","sequence":"first","affiliation":[{"name":"General Intensive Care Unit, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adir","family":"Israeli","sequence":"additional","affiliation":[{"name":"The Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-2482","authenticated-orcid":false,"given":"Lior","family":"Hassan","sequence":"additional","affiliation":[{"name":"The Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410101, Israel"},{"name":"Clinical Research Center, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-7353","authenticated-orcid":false,"given":"Yair","family":"Binyamin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-1643","authenticated-orcid":false,"given":"Matthew","family":"Boyko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Novack","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"},{"name":"Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-8406","authenticated-orcid":false,"given":"Amit","family":"Frenkel","sequence":"additional","affiliation":[{"name":"General Intensive Care Unit, Soroka University Medical Center, the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4103\/lungindia.lungindia_54_16","article-title":"Predictors of Mortality of Severe Sepsis among Adult Patients in the Medical Intensive Care Unit","volume":"34","author":"Mohamed","year":"2017","journal-title":"Lung India Off. Organ Indian Chest Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/ajrccm.153.2.8564118","article-title":"Bedside Prediction of Mortality from Bacteremic Sepsis. A Dynamic Analysis of ICU Patients","volume":"153","author":"Pittet","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1378\/chest.128.6.3937","article-title":"Management of Patients Requiring Prolonged Mechanical Ventilation: Report of a NAMDRC Consensus Conference","volume":"128","author":"MacIntyre","year":"2005","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/CCM.0b013e3181ef4460","article-title":"The Epidemiology of Mechanical Ventilation Use in the United States","volume":"38","author":"Wunsch","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0749-0704(02)00015-5","article-title":"The Epidemiology and Costs of Chronic Critical Illness","volume":"18","author":"Carson","year":"2002","journal-title":"Crit. Care Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S2213-2600(15)00150-2","article-title":"Long-Term Survival of Critically Ill Patients Treated with Prolonged Mechanical Ventilation: A Systematic Review and Meta-Analysis","volume":"3","author":"Damuth","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-0032-1321985","article-title":"Medical and Economic Implications of Prolonged Mechanical Ventilation and Expedited Post\u2013Acute Care","volume":"Volume 33","author":"Cox","year":"2012","journal-title":"Seminars in Respiratory and Critical Care Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1164\/ajrccm.159.5.9809002","article-title":"Outcomes after Long-Term Acute Care: An Analysis of 133 Mechanically Ventilated Patients","volume":"159","author":"Carson","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_9","unstructured":"Jameson, J.L., Kasper, D.L., Fauci, A.S., Hauser, S.L., Longo, D.L., and Loscalzo, J. (2018). Harrison\u2019s Principles of Internal Medicine, McGraw-hill Education."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1513\/AnnalsATS.201610-792OC","article-title":"Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation","volume":"14","author":"Hill","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/s13054-019-2663-7","article-title":"The SOFA Score\u2014Development, Utility and Challenges of Accurate Assessment in Clinical Trials","volume":"23","author":"Lambden","year":"2019","journal-title":"Crit. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients","volume":"286","author":"Bross","year":"2001","journal-title":"JAMA J. Am. Med. 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