{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:11:45Z","timestamp":1790187105427,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Externally Sponsored Scientific Research","award":["ESR-18-13815"],"award-info":[{"award-number":["ESR-18-13815"]}]},{"name":"Spanish Society of Cardiology","award":["ESR-18-13815"],"award-info":[{"award-number":["ESR-18-13815"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Patients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. Unstructured data from the Electronic Health Records were extracted by EHRead\u00ae, a technology based on Natural Language Processing and machine learning. The association between new MACE and the variables of interest were investigated by univariable and multivariable analyses. From a source population of 2,184,662 patients, we identified 4072 adults diagnosed with T2DM and CAD (62.2% male, mean age 70 \u00b1 11). The main comorbidities observed included arterial hypertension, hyperlipidemia, and obesity, with metformin and statins being the treatments most frequently prescribed. MACE development was associated with multivessel (Hazard Ratio (HR) = 2.49) and single coronary vessel disease (HR = 1.71), transient ischemic attack (HR = 2.01), heart failure (HR = 1.32), insulin treatment (HR = 1.40), and percutaneous coronary intervention (PCI) (HR = 2.27), whilst statins (HR = 0.73) were associated with a lower risk of MACE occurrence. In conclusion, we found six risk factors associated with the development of MACE which were related with cardiovascular diseases and T2DM severity, and treatment with statins was identified as a protective factor for new MACE in this study.<\/jats:p>","DOI":"10.3390\/jcm11206004","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T22:18:13Z","timestamp":1665526693000},"page":"6004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-9778","authenticated-orcid":false,"given":"Carlos","family":"Gonz\u00e1lez-Juanatey","sequence":"first","affiliation":[{"name":"Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Anguita-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda, Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, 14014 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-7685","authenticated-orcid":false,"given":"Vivencio","family":"Barrios","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"N\u00fa\u00f1ez-Gil","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-639X","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"G\u00f3mez-Doblas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria CIBERCV (Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares) and IBIMA (Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-8378","authenticated-orcid":false,"given":"Xavier","family":"Garc\u00eda-Moll","sequence":"additional","affiliation":[{"name":"Hospital Universitario Santa Creu i Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lafuente-Gormaz","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-3507","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Roll\u00e1n-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Universitario R\u00edo Hortega, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Peral-Disdier","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ednez-Dolz","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe, CIBERCV, IIS La Fe, 46026 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Rodr\u00edguez-Santamarta","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-1271","authenticated-orcid":false,"given":"Xavier","family":"Vi\u00f1olas-Prat","sequence":"additional","affiliation":[{"name":"Hospital Universitario Santa Creu i Sant Pau, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-6084","authenticated-orcid":false,"given":"Toni","family":"Soriano-Colom\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Vall d\u2019Hebron, CIBERCV, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mu\u00f1oz-Aguilera","sequence":"additional","affiliation":[{"name":"Hospital Infanta Leonor, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Plaza","sequence":"additional","affiliation":[{"name":"Hospital Infanta Sof\u00eda, 28703 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-1441","authenticated-orcid":false,"given":"Alejandro","family":"Curcio-Ruig\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Orts-Soler","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Castell\u00f3n, 12004 Castell\u00f3n de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-3416","authenticated-orcid":false,"given":"Javier","family":"Segovia","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro, 28222 Madrid, 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