{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:26:58Z","timestamp":1776540418035,"version":"3.51.2"},"reference-count":29,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The primary objective was to evaluate bone fragility prevalence on dual X-ray absorptiometry (DXA) and computed tomography (CT) in patients with severe obesity. The secondary objective was to evaluate the risk factors for bone fragility. This monocentric study was conducted in patients with grade 2 and 3 obesity. Bone mineral density (BMD) and T-score were studied on DXA, and the scanographic bone attenuation coefficient of L1 (SBAC-L1) was measured on CT. Among the 1386 patients included, 1013 had undergone both DXA and CT within less than 2 years. The mean age was 48.4 (\u00b111.4) years, 77.6% were women, and the mean BMI was 45.6 (\u00b16.7) kg\/m\u00b2. Eight patients (0.8%) had osteoporosis in at least one site. The mean SBAC-L1 was 192.3 (\u00b152.4) HU; 163 patients (16.1%) were under the threshold of 145 HU. Older age (OR[CI95] = 1.1 [1.08\u20131.16]), lower BMD on the femoral neck and spine (OR[CI95] = 0.04[0.005\u20130.33] and OR[CI95] = 0.001[0.0001\u20130.008], respectively), and higher lean mass (OR[CI95] = 1.1 [1.03\u20131.13]) were significantly associated with an SBAC-L1 \u2264 145 HU in multivariate analysis. Approximately 16% of patients with severe obesity were under the SBAC-L1 threshold, while less than 1% were classified as osteoporotic on DXA.<\/jats:p>","DOI":"10.3390\/jcm11206114","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T21:11:51Z","timestamp":1666041111000},"page":"6114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Osteoporosis Assessed by DXA and\/or CT in Severe Obese Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Marion","family":"Halin","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-6979","authenticated-orcid":false,"given":"Edem","family":"Allado","sequence":"additional","affiliation":[{"name":"University Center of Sports Medicine and Adapted Physical Activity, CHRU-Nancy, F-54000 Nancy, France"},{"name":"DevAH, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-7549","authenticated-orcid":false,"given":"Eliane","family":"Albuisson","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9thodologie, Data Management et Statistiques (UMDS), D\u00e9partement MPI, DRCI, CHRU-Nancy, F-54000 Nancy, France"},{"name":"IECL, CNRS, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-6660","authenticated-orcid":false,"given":"Laurent","family":"Brunaud","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Multidisciplinaire de la Chirurgie de L\u2019ob\u00e9sit\u00e9 (UMCO), University Hospital, F-54000 Nancy, France"},{"name":"Inserm UMRS 1256 N-GERE (Nutrition-Genetics-Environmental Risks), Faculty of Medicine, University de Lorraine, F-54000 Nancy, France"},{"name":"Department of Digestive, Hepato-Biliary and Endocrine Surgery, University Hospital, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Chary-Valckenaere","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital, F-54000 Nancy, France"},{"name":"Ing\u00e9nierie Mol\u00e9culaire et Physiopathologie Articulaire (IMoPA), UMR 7365 CNRS\u2014University of Lorraine, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Loeuille","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital, F-54000 Nancy, France"},{"name":"Ing\u00e9nierie Mol\u00e9culaire et Physiopathologie Articulaire (IMoPA), UMR 7365 CNRS\u2014University of Lorraine, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Quilliot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Multidisciplinaire de la Chirurgie de L\u2019ob\u00e9sit\u00e9 (UMCO), University Hospital, F-54000 Nancy, France"},{"name":"Inserm UMRS 1256 N-GERE (Nutrition-Genetics-Environmental Risks), Faculty of Medicine, University de Lorraine, F-54000 Nancy, France"},{"name":"Department of Endocrinology Diabetology and Nutrition, University Hospital, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-0531","authenticated-orcid":false,"given":"Marine","family":"Fauny","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital, F-54000 Nancy, France"},{"name":"Department of Rheumatology, Saint Charles Hospital, F-54200 Toul, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","unstructured":"WHO (1995). 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