{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:32:27Z","timestamp":1762918347438,"version":"build-2065373602"},"reference-count":95,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"capital medical development research fund","award":["2022-2-2015","81371289","7212047"],"award-info":[{"award-number":["2022-2-2015","81371289","7212047"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"publisher","award":["2022-2-2015","81371289","7212047"],"award-info":[{"award-number":["2022-2-2015","81371289","7212047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["2022-2-2015","81371289","7212047"],"award-info":[{"award-number":["2022-2-2015","81371289","7212047"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Ischemic cerebrovascular disease (ICD), the most common neurological disease worldwide, can be classified based on the onset time (acute\/chronic) and the type of cerebral blood vessel involved (artery or venous sinus). Classifications include acute ischemic stroke (AIS)\/transient ischemic attack (TIA), chronic cerebral circulation insufficiency (CCCI), acute cerebral venous sinus thrombosis (CVST), and chronic cerebrospinal venous insufficiency (CCSVI). The pathogenesis of cerebral arterial ischemia may be correlated with cerebral venous ischemia through decreased cerebral perfusion. The core treatment goals for both arterial and venous ICDs include perfusion recovery, reduction of cerebral ischemic injury, and preservation of the neuronal integrity of the involved region as soon as possible; however, therapy based on the current guidelines for either acute ischemic events or chronic cerebral ischemia is not ideal because the recurrence rate of AIS or CVST is still very high. Therefore, this review discusses the neuroprotective effects of four novel potential ICD treatments with high translation rates, known as the BE COOL treatments (Batroxobin, oxygEn, Conditioning, and cOOLing), and subsequently analyzes how BE COOL treatments are used in clinical settings. The combination of batroxobin, oxygen, conditioning, and cooling may be a promising intervention for preserving ischemic tissues.<\/jats:p>","DOI":"10.3390\/jcm11206193","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T22:49:46Z","timestamp":1666306186000},"page":"6193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The BE COOL Treatments (Batroxobin, oxygEn, Conditioning, and cOOLing): Emerging Adjunct Therapies for Ischemic Cerebrovascular Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Siying","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China"},{"name":"Department of China, America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China"},{"name":"Department of China, America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China"},{"name":"Department of China, America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.14336\/AD.2020.0404","article-title":"Pathogenesis and management in cerebrovenous outflow disorders","volume":"12","author":"Bai","year":"2021","journal-title":"Aging Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/cns.12859","article-title":"Understanding jugular venous outflow disturbance","volume":"24","author":"Zhou","year":"2018","journal-title":"CNS Neurosci. 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