{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:12:33Z","timestamp":1782537153217,"version":"3.54.5"},"reference-count":23,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: The vascular type of Ehlers\u2013Danlos syndrome (vEDS) is a rare genetic connective tissue disorder caused by pathogenic variants in the COL3A1 gene that result in arterial and organ fragility and premature death. We present five cases of vEDS that highlight the diagnosis and treatment challenges encountered by clinicians with these patients. (2) Case presentations: we present the cases of five patients with vascular complications of vEDS who were successfully managed using endovascular interventions or hybrid techniques at our institution from 2005 to 2022. (3) Conclusions: These data emphasize that a multidisciplinary approach is needed for vEDS patients and that when endovascular or hybrid treatment is performed in a timely manner by a skilled team of interventional radiologists, good results can be achieved. Our report also demonstrates that the prognosis of vEDS patients has improved over the past 20 years with a new prevention program including celiprolol therapy, physical activity adaptation and limitation, and scheduled monitoring by expert clinicians.<\/jats:p>","DOI":"10.3390\/jcm11216344","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"6344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Endovascular Management of Vascular Complications in Ehlers\u2013Danlos Syndrome Type IV"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-4900","authenticated-orcid":false,"given":"Mubarak","family":"Alqahtani","sequence":"first","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Claudinot","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Gaudry","sequence":"additional","affiliation":[{"name":"Aortic Center, Hopital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"Department of Vascular Surgery, Hopital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"CRMBM-UMR CNRS 7339, Aix-Marseille University, 13007 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Antoine","family":"Barral","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, 63100 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Busa","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Hopital Enfants de la Timone, AP-HM, 13005 Marseille, France"},{"name":"Regional Reference Department for Marfan and Related Diseases, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0304","authenticated-orcid":false,"given":"Farah","family":"Cadour","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jacquier","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"CRMBM-UMR CNRS 7339, Aix-Marseille University, 13007 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-8112","authenticated-orcid":false,"given":"Mariangela","family":"De Masi","sequence":"additional","affiliation":[{"name":"Aortic Center, Hopital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"Department of Vascular Surgery, Hopital de la Timone, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bal","sequence":"additional","affiliation":[{"name":"Aortic Center, Hopital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"Department of Vascular Surgery, Hopital de la Timone, AP-HM, 13005 Marseille, France"},{"name":"Regional Reference Department for Marfan and Related Diseases, AP-HM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/bmj.2.5552.612","article-title":"Heterogeneity of the Ehlers-Danlos Syndrome: Description of Three Clinical Types and a Hypothesis to Explain the Basic Defect(s)","volume":"2","author":"Barabas","year":"1967","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM200003093421001","article-title":"Clinical and Genetic Features of Ehlers\u2013Danlos Syndrome Type IV, the Vascular Type","volume":"342","author":"Pepin","year":"2000","journal-title":"N. 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