{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:35:00Z","timestamp":1792758900784,"version":"4.5.0"},"reference-count":149,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Vasoplegic syndrome (VS) is a common complication following cardiovascular surgery with cardiopulmonary bypass (CPB), and its incidence varies from 5 to 44%. It is defined as a distributive form of shock due to a significant drop in vascular resistance after CPB. Risk factors of VS include heart failure with low ejection fraction, renal failure, pre-operative use of angiotensin-converting enzyme inhibitors, prolonged aortic cross-clamp and left ventricular assist device surgery. The pathophysiology of VS after CPB is multi-factorial. Surgical trauma, exposure to the elements of the CPB circuit and ischemia-reperfusion promote a systemic inflammatory response with the release of cytokines (IL-1\u03b2, IL-6, IL-8, and TNF-\u03b1) with vasodilating properties, both direct and indirect through the expression of inducible nitric oxide (NO) synthase. The resulting increase in NO production fosters a decrease in vascular resistance and a reduced responsiveness to vasopressor agents. Further mechanisms of vasodilation include the lowering of plasma vasopressin, the desensitization of adrenergic receptors, and the activation of ATP-dependent potassium (KATP) channels. Patients developing VS experience more complications and have increased mortality. Management includes primarily fluid resuscitation and conventional vasopressors (catecholamines and vasopressin), while alternative vasopressors (angiotensin 2, methylene blue, hydroxocobalamin) and anti-inflammatory strategies (corticosteroids) may be used as a rescue therapy in deteriorating patients, albeit with insufficient evidence to provide any strong recommendation. In this review, we present an update of the pathophysiological mechanisms of vasoplegic syndrome complicating CPB and discuss available therapeutic options.<\/jats:p>","DOI":"10.3390\/jcm11216407","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T07:26:50Z","timestamp":1667114810000},"page":"6407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care"],"prefix":"10.3390","volume":"11","author":[{"given":"Zied","family":"Ltaief","sequence":"first","affiliation":[{"name":"Service of Adult Intensive Care, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-5223","authenticated-orcid":false,"given":"Nawfel","family":"Ben-Hamouda","sequence":"additional","affiliation":[{"name":"Service of Adult Intensive Care, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Rancati","sequence":"additional","affiliation":[{"name":"Service of Anesthesiology, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad","family":"Gunga","sequence":"additional","affiliation":[{"name":"Service of Cardiac Surgery, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Service of Anesthesiology, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Service of Cardiac Surgery, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Liaudet","sequence":"additional","affiliation":[{"name":"Service of Adult Intensive Care, Lausanne University Hospital and University of Lausanne, 1010 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/00003246-199906000-00033","article-title":"Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass","volume":"27","author":"Kristof","year":"1999","journal-title":"Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0022-5223(02)73284-4","article-title":"Methylene blue: The drug of choice for catecholamine-refractory vasoplegia after cardiopulmonary bypass?","volume":"125","author":"Leyh","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4037\/aacnacc2021299","article-title":"Vasoplegic Syndrome in Patients Undergoing Cardiac Surgery: A Literature Review","volume":"32","author":"Nash","year":"2021","journal-title":"AACN Adv. Crit. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/MAJ.0000000000000341","article-title":"Cardiac vasoplegia syndrome: Pathophysiology, risk factors and treatment","volume":"349","author":"Omar","year":"2015","journal-title":"Am. J. Med. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13019-021-01579-8","article-title":"The additional use of methylene blue has a decatecholaminisation effect on cardiac vasoplegic syndrome after cardiac surgery","volume":"16","author":"Petermichl","year":"2021","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1378\/chest.112.3.676","article-title":"Inflammatory response to cardiopulmonary bypass: Mechanisms involved and possible therapeutic strategies","volume":"112","author":"Wan","year":"1997","journal-title":"Chest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0022-5223(94)70355-8","article-title":"Vasoplegic syndrome: A new dilemma","volume":"107","author":"Gomes","year":"1994","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/0003-4975(96)00055-0","article-title":"Systemic inflammatory response syndrome after cardiac operations","volume":"61","author":"Cremer","year":"1996","journal-title":"Ann. Thorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1056\/NEJMoa0907118","article-title":"Comparison of Dopamine and Norepinephrine in the Treatment of Shock","volume":"362","author":"Biston","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0022-5223(98)70049-2","article-title":"Management of vasodilatory shock after cardiac surgery: Identification of predisposing factors and use of a novel pressor agent","volume":"116","author":"Argenziano","year":"1998","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_11","first-page":"II-286","article-title":"A prospective randomized trial of arginine vasopressin in the treatment of vasodilatory shock after left ventricular assist device placement","volume":"96","author":"Argenziano","year":"1997","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.108.814533","article-title":"Early on-cardiopulmonary bypass hypotension and other factors associated with vasoplegic syndrome","volume":"120","author":"Levin","year":"2009","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ALN.0000000000001434","article-title":"Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery: The VANCS Randomized Controlled Trial","volume":"126","author":"Hajjar","year":"2017","journal-title":"Anesthesiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0971-9784.154462","article-title":"30-day mortality after coronary artery bypass grafting and valve surgery has greatly improved over the last decade, but the 1-year mortality remains constant","volume":"18","author":"Hansen","year":"2015","journal-title":"Ann. Card. Anaesth."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.athoracsur.2013.10.040","article-title":"In-hospital mortality after cardiac surgery: Patient characteristics, timing, and association with postoperative length of intensive care unit and hospital stay","volume":"97","author":"Mazzeffi","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMra002709","article-title":"The pathogenesis of vasodilatory shock","volume":"345","author":"Landry","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.286.5444.1583","article-title":"Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha","volume":"286","author":"Surks","year":"1999","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1213\/00000539-199710000-00011","article-title":"The systemic inflammatory response to cardiopulmonary bypass: Pathophysiological, therapeutic, and pharmacological considerations","volume":"85","author":"Hall","year":"1997","journal-title":"Anesth. Analg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0003-4975(97)00545-6","article-title":"Thrombus formation on a calcific and severely stenotic bicuspid aortic valve","volume":"64","author":"Wan","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.1991.sp018661","article-title":"Cyclic AMP relaxes swine arterial smooth muscle predominantly by decreasing cell Ca2+ concentration","volume":"439","author":"McDaniel","year":"1991","journal-title":"J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0008-6363(95)00101-8","article-title":"Effects of inflammatory cytokines on vascular tone","volume":"30","author":"Ohkawa","year":"1995","journal-title":"Cardiovasc. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-2044.2006.04779.x","article-title":"Association between vasopressor dependence and early outcome in patients after cardiac surgery","volume":"61","author":"Weis","year":"2006","journal-title":"Anaesthesia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/01.CCM.0000059646.89546.98","article-title":"Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery","volume":"31","author":"Kilger","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/icvts\/ivy352","article-title":"Risk factors for vasoplegia after cardiac surgery: A meta-analysis","volume":"28","author":"Dayan","year":"2019","journal-title":"Interact Cardiovasc. Thorac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-2743-8","article-title":"Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options","volume":"24","author":"Busse","year":"2020","journal-title":"Crit. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/SHK.0b013e31821a4002","article-title":"Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: Role of nitric oxide and \u03b1\u2081-adrenoceptor mRNA expression","volume":"36","author":"Kandasamy","year":"2011","journal-title":"Shock"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13054-018-1967-3","article-title":"Vasoplegia treatments: The past, the present, and the future","volume":"22","author":"Levy","year":"2018","journal-title":"Crit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/thx.50.4.403","article-title":"Ca(2+)-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass","volume":"50","author":"Delgado","year":"1995","journal-title":"Thorax"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1164\/ajrccm.152.6.8520738","article-title":"Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass","volume":"152","author":"Hill","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.ATV.21.1.28","article-title":"Potassium Channel Function in Vascular Disease","volume":"21","author":"Sobey","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"R255","DOI":"10.1186\/cc10516","article-title":"Post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration","volume":"15","author":"Colson","year":"2011","journal-title":"Crit. Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/01.CIR.95.5.1122","article-title":"Vasopressin deficiency contributes to the vasodilation of septic shock","volume":"95","author":"Landry","year":"1997","journal-title":"Circulation"},{"key":"ref_35","first-page":"652","article-title":"[Vasopressin in the critically ill patient]","volume":"16","author":"Cuda","year":"2020","journal-title":"Rev. Med. Suisse"},{"key":"ref_36","first-page":"H491","article-title":"Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery","volume":"263","author":"Wakatsuki","year":"1992","journal-title":"Am J. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.CCM.0000251127.45385.CD","article-title":"Vasopressin: Mechanisms of action on the vasculature in health and in septic shock","volume":"35","author":"Barrett","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/01.HYP.18.2.165","article-title":"Cellular mechanism of endothelin-1 release by angiotensin and vasopressin","volume":"18","author":"Emori","year":"1991","journal-title":"Hypertension"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/01.HYP.19.6.753","article-title":"Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells","volume":"19","author":"Imai","year":"1992","journal-title":"Hypertension"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/bj2330083","article-title":"Activation of V1-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets","volume":"233","author":"Siess","year":"1986","journal-title":"Biochem. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1540\/jsmr.44.65","article-title":"Physiological roles of K+ channels in vascular smooth muscle cells","volume":"44","author":"Ko","year":"2008","journal-title":"J. Smooth Muscle Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/343375a0","article-title":"Modulation of ATP-sensitive K+ channels in skeletal muscle by intracellular protons","volume":"343","author":"Davies","year":"1990","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1172\/JCI115497","article-title":"Lactate activates ATP-sensitive potassium channels in guinea pig ventricular myocytes","volume":"88","author":"Keung","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1172\/JCI115820","article-title":"The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog","volume":"89","author":"Landry","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1124\/mol.105.017467","article-title":"Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells","volume":"68","author":"Tang","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s13054-020-03055-6","article-title":"Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease","volume":"24","author":"Liaudet","year":"2020","journal-title":"Crit. Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jtcvs.2021.02.097","article-title":"Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients","volume":"163","author":"Chow","year":"2022","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1051\/ject\/201749174","article-title":"Endothelial Glycocalyx and Cardiopulmonary Bypass","volume":"49","author":"Myers","year":"2017","journal-title":"J. Extra Corpor. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.1074\/jbc.M113.541573","article-title":"Loss of Syndecan-1 Induces a Pro-inflammatory Phenotype in Endothelial Cells with a Dysregulated Response to Atheroprotective Flow","volume":"289","author":"Voyvodic","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"P212","DOI":"10.1186\/cc12150","article-title":"Changes in microcirculatory perfusion during cardiac surgery are paralleled by alterations in glycocalyx integrity","volume":"17","author":"Boer","year":"2013","journal-title":"Crit. Care"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1053\/j.jvca.2019.09.004","article-title":"Vasoplegia After Cardiac Surgery Is Associated with Endothelial Glycocalyx Alterations","volume":"34","author":"Kamel","year":"2020","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.00282.2016","article-title":"Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: Mechanisms and implications","volume":"312","author":"Szabo","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"ref_54","first-page":"208","article-title":"Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock","volume":"11","author":"Coletta","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1053\/j.jvca.2016.08.019","article-title":"Hydroxocobalamin as a Rescue Treatment for Refractory Vasoplegic Syndrome After Prolonged Cardiopulmonary Bypass","volume":"31","author":"Burnes","year":"2017","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.athoracsur.2013.08.050","article-title":"The Use of High-Dose Hydroxocobalamin for Vasoplegic Syndrome","volume":"97","author":"Roderique","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s11748-017-0789-6","article-title":"Risk assessment and outcomes of vasoplegia after cardiac surgery","volume":"65","author":"Tsiouris","year":"2017","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_58","first-page":"532","article-title":"Incidence and predictors of vasoplegia after heart failure surgery","volume":"51","author":"Palmen","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cardfail.2021.01.022","article-title":"Universal Definition and Classification of Heart Failure: A Report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure","volume":"27","author":"Bozkurt","year":"2021","journal-title":"J. Card. Fail."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e013108","DOI":"10.1161\/JAHA.119.013108","article-title":"Predictors and Clinical Outcomes of Vasoplegia in Patients Bridged to Heart Transplantation with Continuous-Flow Left Ventricular Assist Devices","volume":"8","author":"Asleh","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/ndt\/16.6.1189","article-title":"Endothelial dysfunction in chronic renal failure: Roles of lipoprotein oxidation and pro-inflammatory cytokines","volume":"16","author":"Bolton","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1510\/icvts.2007.174698","article-title":"Should angiotensin converting enzyme inhibitors\/angiotensin II receptor antagonists be omitted before cardiac surgery to avoid postoperative vasodilation?","volume":"7","author":"Raja","year":"2008","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4330\/wjc.v14.i4.250","article-title":"Effect of preoperative renin-angiotensin system blockade on vasoplegia after cardiac surgery: A systematic review with meta-analysis","volume":"14","author":"Noubiap","year":"2022","journal-title":"World J. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/bja\/83.5.715","article-title":"Effect of omitting regular ACE inhibitor medication before cardiac surgery on haemodynamic variables and vasoactive drug requirements","volume":"83","author":"Pigott","year":"1999","journal-title":"Br. J. Anaesth."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1010-7940(97)00284-4","article-title":"The effect of angiotensin converting enzyme inhibition on myocardial function and blood pressure after coronary artery bypass surgery--a randomised study","volume":"13","author":"Webb","year":"1998","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/bja\/aeg013","article-title":"Effect of preoperative beta-blockade on perioperative mortality in coronary surgery","volume":"90","author":"Mertens","year":"2003","journal-title":"Br. J. Anaesth."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.healun.2011.10.010","article-title":"Pre-operative risk factors and clinical outcomes associated with vasoplegia in recipients of orthotopic heart transplantation in the contemporary era","volume":"31","author":"Patarroyo","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejcts.2003.11.032","article-title":"Risk factors and outcomes for \u2018vasoplegia syndrome\u2019 following cardiac transplantation","volume":"25","author":"Byrne","year":"2004","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_69","first-page":"619","article-title":"Vasoplegic syndrome after open heart surgery","volume":"39","author":"Gomes","year":"1998","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1051\/ject\/201446197","article-title":"Attenuating the Systemic Inflammatory Response to Adult Cardiopulmonary Bypass: A Critical Review of the Evidence Base","volume":"46","author":"Landis","year":"2014","journal-title":"J. Extra Corpor. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2012.01.020","article-title":"Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials","volume":"164","author":"Anastasiadis","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory Shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.15441\/ceem.16.128","article-title":"Stressed vs. unstressed volume and its relevance to critical care practitioners","volume":"3","author":"Spiegel","year":"2016","journal-title":"Clin. Exp. Emerg. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CCM.0b013e3181feeb15","article-title":"Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality","volume":"39","author":"Boyd","year":"2011","journal-title":"Crit. Care Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00134-016-4237-3","article-title":"Higher versus lower blood pressure targets for vasopressor therapy in shock: A multicentre pilot randomized controlled trial","volume":"42","author":"Lamontagne","year":"2016","journal-title":"Intensive Care Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1378\/chest.13-2104","article-title":"Early Management of Severe Sepsis: Concepts and Controversies","volume":"145","author":"Marik","year":"2014","journal-title":"Chest"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/jama.2019.0071","article-title":"Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients with Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial","volume":"321","author":"Damiani","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s13054-021-03671-w","article-title":"Pathophysiology and clinical implications of the veno-arterial PCO2 gap","volume":"25","author":"Ltaief","year":"2021","journal-title":"Crit. Care"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1053\/j.jvca.2017.10.032","article-title":"Vasoplegia After Cardiovascular Procedures-Pathophysiology and Targeted Therapy","volume":"32","author":"Shaefi","year":"2018","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bjae.2018.03.005","article-title":"Assessing dynamic fluid-responsiveness using transthoracic echocardiography in intensive care","volume":"18","author":"Desai","year":"2018","journal-title":"BJA Educ."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/ALN.0b013e318229a500","article-title":"An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: The mini-fluid challenge study","volume":"115","author":"Muller","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/EJA.0000000000001406","article-title":"Mini fluid chAllenge aNd End-expiratory occlusion test to assess flUid responsiVEness in the opeRating room (MANEUVER study): A multicentre cohort study","volume":"38","author":"Messina","year":"2021","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1001\/jama.2010.1446","article-title":"Transfusion requirements after cardiac surgery: The TRACS randomized controlled trial","volume":"304","author":"Hajjar","year":"2010","journal-title":"JAMA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.athoracsur.2017.05.048","article-title":"A Randomized Clinical Trial of Red Blood Cell Transfusion Triggers in Cardiac Surgery","volume":"104","author":"Koch","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1711818","article-title":"Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery","volume":"377","author":"Mazer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa1403612","article-title":"Liberal or restrictive transfusion after cardiac surgery","volume":"372","author":"Murphy","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/jama.2019.0554","article-title":"Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference","volume":"321","author":"Mueller","year":"2019","journal-title":"JAMA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.athoracsur.2021.03.033","article-title":"STS\/SCA\/AmSECT\/SABM Update to the Clinical Practice Guidelines on Patient Blood Management","volume":"112","author":"Tibi","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/0735-1097(95)00007-Q","article-title":"Endothelium-derived relaxing factor is important in mediating the high output state in chronic severe anemia","volume":"25","author":"Anand","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1476-5381.1986.tb11157.x","article-title":"The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor","volume":"89","author":"Martin","year":"1986","journal-title":"Br. J. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/HYPERTENSIONAHA.112.193565","article-title":"Hemoglobin level is positively associated with blood pressure in a large cohort of healthy individuals","volume":"60","author":"Atsma","year":"2012","journal-title":"Hypertension"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1056\/NEJMoa1312173","article-title":"High versus low blood-pressure target in patients with septic shock","volume":"370","author":"Asfar","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/jama.2020.0930","article-title":"Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients with Vasodilatory Hypotension: A Randomized Clinical Trial","volume":"323","author":"Lamontagne","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00134-019-05544-x","article-title":"Challenges in the management of septic shock: A narrative review","volume":"45","author":"Cecconi","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s13054-020-03204-x","article-title":"Timing of norepinephrine initiation in patients with septic shock: A systematic review and meta-analysis","volume":"24","author":"Li","year":"2020","journal-title":"Crit. Care"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00134-021-06595-9","article-title":"Current practice and evolving concepts in septic shock resuscitation","volume":"48","author":"Bakker","year":"2022","journal-title":"Intensive Care Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1053\/j.jvca.2020.11.032","article-title":"Vasopressor Therapy in Cardiac Surgery-An Experts\u2019 Consensus Statement","volume":"35","author":"Guarracino","year":"2021","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13613-015-0052-1","article-title":"Experts\u2019 recommendations for the management of adult patients with cardiogenic shock","volume":"5","author":"Levy","year":"2015","journal-title":"Ann. Intensive Care"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Sponholz, C., Schelenz, C., Reinhart, K., Schirmer, U., and Stehr, S.N. (2014). Catecholamine and volume therapy for cardiac surgery in Germany\u2013results from a postal survey. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103996"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1164\/rccm.202002-0339OC","article-title":"Norepinephrine Dysregulates the Immune Response and Compromises Host Defense during Sepsis","volume":"202","author":"Stolk","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/01.CIR.0000066692.71008.BB","article-title":"Arginine vasopressin in advanced vasodilatory shock: A prospective, randomized, controlled study","volume":"107","author":"Mayr","year":"2003","journal-title":"Circulation"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00134-009-1630-1","article-title":"Comparing two different arginine vasopressin doses in advanced vasodilatory shock: A randomized, controlled, open-label trial","volume":"36","author":"Torgersen","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jtcvs.2010.03.012","article-title":"Comparative effects of norepinephrine and vasopressin on internal thoracic arterial graft flow after off-pump coronary artery bypass grafting","volume":"141","author":"Park","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1749-8090-8-49","article-title":"The effect of vasopressin on the hemodynamics in CABG patients","volume":"8","author":"Hu","year":"2013","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1053\/j.jvca.2018.04.006","article-title":"Vasopressin in Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials","volume":"32","author":"Bouvet","year":"2018","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.2018.4528","article-title":"Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone with Atrial Fibrillation in Patients with Distributive Shock: A Systematic Review and Meta-analysis","volume":"319","author":"McIntyre","year":"2018","journal-title":"J. Am. Med. Assoc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/CCM.0000000000003471","article-title":"Renal Outcomes of Vasopressin and Its Analogs in Distributive Shock: A Systematic Review and Meta-Analysis of Randomized Trials","volume":"47","author":"Nedel","year":"2019","journal-title":"Crit. Care Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the Treatment of Vasodilatory Shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.jvca.2020.08.001","article-title":"Treatment with Angiotensin II Is Associated with Rapid Blood Pressure Response and Vasopressor Sparing in Patients With Vasoplegia After Cardiac Surgery: A Post-Hoc Analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study","volume":"35","author":"Klijian","year":"2021","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/anae.15802","article-title":"A double-blind randomised feasibility trial of angiotensin-2 in cardiac surgery","volume":"77","author":"Coulson","year":"2022","journal-title":"Anaesthesia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/PEC.0000000000002526","article-title":"Methylene Blue: An Antidote for Methemoglobinemia and Beyond","volume":"37","author":"Liebelt","year":"2021","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Kofler, O., Simbeck, M., Tomasi, R., Hinske, L.C., Klotz, L.V., Uhle, F., Born, F., Pichlmaier, M., Hagl, C., and Weigand, M.A. (2022). Early Use of Methylene Blue in Vasoplegic Syndrome: A 10-Year Propensity Score-Matched Cohort Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041121"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.athoracsur.2004.10.038","article-title":"Preoperative Methylene Blue Administration in Patients at High Risk for Vasoplegic Syndrome During Cardiac Surgery","volume":"79","author":"Kuralay","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1067\/mtc.2001.115153","article-title":"Reversal of severe vasoplegia with single-dose methylene blue after heart transplantation","volume":"122","author":"Kofidis","year":"2001","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0003-4975(03)01510-8","article-title":"Methylene blue reduces mortality and morbidity in vasoplegic patients after cardiac surgery","volume":"77","author":"Levin","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-5223(99)70161-3","article-title":"Reversal of refractory hypotension with single-dose methylene blue after coronary artery bypass surgery","volume":"118","author":"Yiu","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.athoracsur.2017.02.057","article-title":"Methylene Blue for Vasoplegic Syndrome After Cardiac Operation: Early Administration Improves Survival","volume":"104","author":"Mehaffey","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_119","unstructured":"Ramezanpour Ahangar, E., and Annamaraju, P. (2022). Hydroxocobalamin, StatPearls Publishing."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.freeradbiomed.2009.03.017","article-title":"Inhibition of nitric oxide synthase by cobalamins and cobinamides","volume":"46","author":"Weinberg","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_121","first-page":"665","article-title":"Spectroscopic studies of nitric oxide (NO) interactions with cobalamins: Reaction of NO with superoxocobalamin(III) likely accounts for cobalamin reversal of the biological effects of NO","volume":"285","author":"Kruszyna","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/15563650.2014.990976","article-title":"High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep","volume":"53","author":"Haouzi","year":"2015","journal-title":"Clin. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13181-019-00710-5","article-title":"Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development","volume":"15","author":"Ng","year":"2019","journal-title":"J. Med. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1053\/j.jvca.2018.08.017","article-title":"Hydroxocobalamin for the Treatment of Vasoplegia: A Review of Current Literature and Considerations for Use","volume":"33","author":"Shapeton","year":"2019","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/01.ccm.0000508898.30711.31","article-title":"Evaluation of hydroxocobalamin in vasoplegia in cardiac surgery","volume":"44","author":"Klemm","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_126","first-page":"e28267","article-title":"High-Dose Hydroxocobalamin for Refractory Vasoplegia Post Cardiac Surgery","volume":"14","author":"Bak","year":"2022","journal-title":"Cureus"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s12630-017-1029-3","article-title":"Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: A case series","volume":"65","author":"Shah","year":"2018","journal-title":"Can. J. Anaesth."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hrtlng.2020.11.003","article-title":"Extended duration infusion of high-dose hydroxocobalamin for vasoplegic syndrome following cardiac surgery","volume":"50","author":"Seelhammer","year":"2021","journal-title":"Heart Lung"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s13054-015-1131-2","article-title":"Ascorbate-dependent vasopressor synthesis: A rationale for vitamin C administration in severe sepsis and septic shock?","volume":"19","author":"Carr","year":"2015","journal-title":"Crit. Care"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"H2353","DOI":"10.1152\/ajpheart.00968.2003","article-title":"Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle","volume":"286","author":"Dillon","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MCO.0000000000000148","article-title":"Vitamin C supplementation in the critically ill patient","volume":"18","author":"Berger","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.nut.2013.10.026","article-title":"Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation","volume":"30","author":"Rodemeister","year":"2014","journal-title":"Nutrition"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1053\/j.jvca.2019.08.034","article-title":"A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery","volume":"34","author":"Yanase","year":"2020","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa2200644","article-title":"Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit","volume":"386","author":"Lamontagne","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1097\/CCM.0000000000005427","article-title":"Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy","volume":"50","author":"Wacker","year":"2022","journal-title":"Crit. Care Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccc.2018.11.005","article-title":"Hydrocortisone in Vasodilatory Shock","volume":"35","author":"Venkatesh","year":"2019","journal-title":"Crit. Care Clin."},{"key":"ref_137","first-page":"L41","article-title":"Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung","volume":"268","author":"Mak","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1172\/JCI115315","article-title":"Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells","volume":"88","author":"Sakaue","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1705716","article-title":"Hydrocortisone plus Fludrocortisone for Adults with Septic Shock","volume":"378","author":"Annane","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jama.288.7.862","article-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock","volume":"288","author":"Annane","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1705835","article-title":"Adjunctive Glucocorticoid Therapy in Patients with Septic Shock","volume":"378","author":"Venkatesh","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/jama.2012.14144","article-title":"Intraoperative high-dose dexamethasone for cardiac surgery: A randomized controlled trial","volume":"308","author":"Dieleman","year":"2012","journal-title":"J. Am. Med. Assoc."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jss.2006.02.013","article-title":"Pulse low dose steroids attenuate post-cardiopulmonary bypass SIRS.; SIRS I","volume":"132","author":"Whitlock","year":"2006","journal-title":"J. Surg. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"832205","DOI":"10.3389\/fsurg.2022.832205","article-title":"Meta-Analysis: Shouldn\u2019t Prophylactic Corticosteroids be Administered During Cardiac Surgery with Cardiopulmonary Bypass?","volume":"9","author":"Chai","year":"2022","journal-title":"Front. Surg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00134-022-06810-1","article-title":"Hemoperfusion in the intensive care unit","volume":"48","author":"Ricci","year":"2022","journal-title":"Intensive Care Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/CIRCULATIONAHA.121.056940","article-title":"Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results from a Multicenter Randomized Controlled Trial","volume":"145","author":"Diab","year":"2022","journal-title":"Circulation"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/CCM.0000000000005023","article-title":"Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis: An Updated Systematic Review of Comparative Efficacy and Safety","volume":"49","author":"Goetz","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Heymann, M., Schorer, R., and Putzu, A. (2022). Mortality and adverse events of hemoadsorption with CytoSorb\u00ae in critically ill patients: A systematic review and meta-analysis of randomized controlled trials. Acta Anaesthesiol. 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