{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:19:04Z","timestamp":1791292744509,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Only three laryngeal transplants have been described in the literature to date, and none of the techniques has enabled a completely satisfactory functional result to be obtained. This article presents a new model of laryngeal transplantation, with quality of revascularisation of the transplant being the principal objective and optimisation of the various steps of the procedure, with the integration of a new reinnervation technique as a secondary objective. We present a preclinical animal study. Three pig larynges removed in vivo underwent allotransplantation according to the same protocol. The quality of the revascularisation was examined immediately after the surgery as well as by endoscopy for one animal on the fourth day after the operation. The mean time of cold ischaemia was 3 h 15 min. The anaesthetic tolerance of the pigs was excellent. Revascularisation was achieved and judged to be excellent for the three transplants immediately after the operation and the endoscopy performed for one pig on the fourth day after the operation confirmed this result. The anatomical similarities also enabled the application and integration of an innovative technique of laryngeal reinnervation into the various phases of the operation. We describe a reliable and reproducible animal model for laryngeal transplantation. Its application in humans can be envisaged.<\/jats:p>","DOI":"10.3390\/jcm11216427","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T07:26:50Z","timestamp":1667114810000},"page":"6427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A New Animal Model of Laryngeal Transplantation"],"prefix":"10.3390","volume":"11","author":[{"given":"Pierre","family":"Philouze","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019ORL et Chirurgie Cervico-Faciale, Croix-Rousse Hospital, Universit\u00e9 Lyon 1, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Malard","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL, H\u00f4tel-Dieu, Universit\u00e9 Nantes, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Albert","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL, H\u00f4pital Bichat, University Paris VII, AP-HP, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Badet","sequence":"additional","affiliation":[{"name":"Service de Chirurgie de la Transplantation et d\u2019Urologie, H\u00f4pital Edouard-Herriot, Universit\u00e9 Lyon 1, 69347 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-3191","authenticated-orcid":false,"given":"Bertrand","family":"Baujat","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et Chirurgie Cervico-Faciale, H\u00f4pital Tenon, APHP, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Faure","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019ORL et Chirurgie Cervico-Faciale, H\u00f4pital Edouard Herriot, Universit\u00e9 Lyon 1, 69100 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Fuchsmann","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019ORL et Chirurgie Cervico-Faciale, Croix-Rousse Hospital, Universit\u00e9 Lyon 1, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Jegoux","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et Chirurgie Maxillo-Faciale, CHU Pontchaillou, Universit\u00e9  Rennes, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lacau-St-Guily","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et Chirurgie Cervico-Faciale, H\u00f4pital Tenon, APHP, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2907-8947","authenticated-orcid":false,"given":"Jean-Paul","family":"Marie","sequence":"additional","affiliation":[{"name":"Service ORL et Chirurgie Cervico-Faciale, H\u00f4pital Charles-Nicolle, CHU Rouen, Universit\u00e9 Rouen Normandie, UR 3830 GRHVN, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Ramade","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019ORL et Chirurgie Cervico-Faciale, Croix-Rousse Hospital, Universit\u00e9 Lyon 1, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Vergez","sequence":"additional","affiliation":[{"name":"Service ORL et Chirurgie Cervicofaciale, CHU Toulouse Rangueil-Larrey, Universit\u00e9 Toulouse, 31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ceruse","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019ORL et Chirurgie Cervico-Faciale, Croix-Rousse Hospital, Universit\u00e9 Lyon 1, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier J.","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Small Animal Surgery and Anesthesia, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering (ONIRIS), 44307 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/TP.0b013e31823d4af6","article-title":"First human face transplantation: 5 years outcomes","volume":"93","author":"Petruzzo","year":"2012","journal-title":"Transplantation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0140-6736(99)02062-0","article-title":"Human hand allograft: Report on first 6 months","volume":"353","author":"Dubernard","year":"1999","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bewley, A.F., and Farwell, D.G. 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