{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:37:29Z","timestamp":1782401849911,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Approximately 25\u201360% of COVID-19 patients develop long-term sequelae of the condition known as long COVID. This study aimed to examine sociodemographic and clinical characteristics of long COVID in Japan. Methods: The data of long COVID patients, defined as those who were symptomatic after 28 days from onset, were collected in an outpatient clinic in Tokyo, Japan between 6 January 2020 and 2 October 2021 (N = 1891). Information on age, sex, employment, infection waves, vaccination, impairment in activities of daily living, and symptoms were obtained from electronic medical records. We used linear regression to analyze the association of patients characteristics with performance status. Results: The mean number of days from onset was 77.6 (SD: 71.3). Female, those who had their work hours reduced, on leave, dismissed or retired or not working, were associated with lower performance status. Fatigue, depressive symptom, brain fog, dyspnea, palpitation, body pain, loss of appetite, fever\u2014but not headache, insomnia, loss of smell, loss of taste, hair loss, or cough\u2014were associated with the lower performance status. Conclusion: Sex and employment status were associated with lower performance status in long COVID patients. Studies are needed to elucidate the full picture of the characteristics of long COVID patients.<\/jats:p>","DOI":"10.3390\/jcm11216457","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:42:17Z","timestamp":1667371337000},"page":"6457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Characteristics of Long COVID: Cases from the First to the Fifth Wave in Greater Tokyo, Japan"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4305-6368","authenticated-orcid":false,"given":"Kouichi","family":"Hirahata","sequence":"first","affiliation":[{"name":"Hirahata Clinic, Tokyo 150-0002, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutoshi","family":"Nawa","sequence":"additional","affiliation":[{"name":"Department of Global Health Promotion, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-3954","authenticated-orcid":false,"given":"Takeo","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Global Health Promotion, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","unstructured":"(2022, March 01). Our World in Data. Available online: https:\/\/ourworldindata.org\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/rheumatology\/keab615","article-title":"The role of chest CT in deciphering interstitial lung involvement: Systemic sclerosis versus COVID-19","volume":"61","author":"Orlandi","year":"2022","journal-title":"Rheumatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12931-022-01994-y","article-title":"One-year pulmonary impairment after severe COVID-19: A prospective, multicenter follow-up study","volume":"23","author":"Faverio","year":"2022","journal-title":"Respir. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Baratella, E., Ruaro, B., Marrocchio, C., Starvaggi, N., Salton, F., Giudici, F., Quaia, E., Confalonieri, M., and Cova, M.A. (2021). Interstitial Lung Disease at High Resolution CT after SARS-CoV-2-Related Acute Respiratory Distress Syndrome According to Pulmonary Segmental Anatomy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173985"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16144","DOI":"10.1038\/s41598-021-95565-8","article-title":"More than 50 long-term effects of COVID-19: A systematic review and meta-analysis","volume":"11","author":"Perelman","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2128568","DOI":"10.1001\/jamanetworkopen.2021.28568","article-title":"Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review","volume":"4","author":"Groff","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2111417","DOI":"10.1001\/jamanetworkopen.2021.11417","article-title":"Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Systematic Review","volume":"4","author":"Nasserie","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/01410768211032850","article-title":"Symptoms, complications and management of long COVID: A review","volume":"114","author":"Aiyegbusi","year":"2021","journal-title":"J. R. Soc. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-Las-Pe\u00f1as, C., Mart\u00edn-Guerrero, J.D., Pellicer-Valero, \u00d3.J., Navarro-Pardo, E., G\u00f3mez-Mayordomo, V., Cuadrado, M.L., Arias-Naval\u00f3n, J.A., Cigar\u00e1n-M\u00e9ndez, M., Hern\u00e1ndez-Barrera, V., and Arendt-Nielsen, L. (2022). Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020413"},{"key":"ref_10","unstructured":"European Observatory on Health Systems and Policies, Rajan, S., Khunti, K., Alwan, N., Steves, C., MacDermott, N., Morsella, A., Angulo, E., Winkelmann, J., and Bryndov\u00e1, L. (2021). In the Wake of the Pandemic: Preparing for Long COVID, Regional Office for Europe."},{"key":"ref_11","unstructured":"World Health Organization (WHO) (2022, October 24). Fact sheets: Post COVID-19 Condition (Long COVID). Available online: https:\/\/www.who.int\/europe\/news-room\/fact-sheets\/item\/post-covid-19-condition."},{"key":"ref_12","first-page":"e18568","article-title":"Clinical Characteristics of Japanese Patients Who Visited a COVID-19 Aftercare Clinic for Post-Acute Sequelae of COVID-19\/Long COVID","volume":"13","author":"Otsuka","year":"2021","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Crankson, S., Pokhrel, S., and Anokye, N.K. (2022). Determinants of COVID-19-Related Length of Hospital Stays and Long COVID in Ghana: A Cross-Sectional Analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19010527"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Hermosillo, J.A., Mart\u00ednez-L\u00f3pez, J.P., Carrillo-Lamp\u00f3n, S.A., Ruiz-Ojeda, D., Herrera-Ram\u00edrez, S., Amezcua-Guerra, L.M., and Mart\u00ednez-Alvarado, M.D.R. (2021). Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort. Brain Sci., 11.","DOI":"10.3390\/brainsci11060760"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jiph.2021.11.016","article-title":"Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hospitalized patients with COVID-19: A cohort study with 4 months median follow-up","volume":"15","author":"Tleyjeh","year":"2022","journal-title":"J. Infect. Public Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmi.2020.09.052","article-title":"Follow-up of adults with noncritical COVID-19 two months after symptom onset","volume":"27","author":"Laurent","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/23744235.2021.1924397","article-title":"Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments","volume":"53","author":"Yong","year":"2021","journal-title":"Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100186","DOI":"10.1016\/j.lanepe.2021.100186","article-title":"Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol","volume":"8","author":"Sigfrid","year":"2021","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jmv.26368","article-title":"Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation","volume":"93","author":"Halpin","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41591-021-01292-y","article-title":"Attributes and predictors of long COVID","volume":"27","author":"Sudre","year":"2021","journal-title":"Nat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cmi.2020.09.023","article-title":"Clinical sequelae of COVID-19 survivors in Wuhan, China: A single-centre longitudinal study","volume":"27","author":"Xiong","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: A cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tleyjeh, I.M., Saddik, B., AlSwaidan, N., AlAnazi, A., Ramakrishnan, R.K., Alhazmi, D., Aloufi, A., AlSumait, F., Berbari, E., and Halwani, R. (2021). Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-up. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0260568"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"n1648","DOI":"10.1136\/bmj.n1648","article-title":"Long covid-mechanisms, risk factors, and management","volume":"374","author":"Crook","year":"2021","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100899","DOI":"10.1016\/j.eclinm.2021.100899","article-title":"Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis","volume":"36","author":"Iqbal","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/s41591-021-01433-3","article-title":"Long COVID in a prospective cohort of home-isolated patients","volume":"27","author":"Blomberg","year":"2021","journal-title":"Nat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/cea.13997","article-title":"Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19","volume":"51","author":"Munblit","year":"2021","journal-title":"Clin. Exp. Allergy"},{"key":"ref_28","first-page":"1191","article-title":"Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study","volume":"74","author":"Waterboer","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jinf.2021.01.004","article-title":"Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study","volume":"82","author":"Merino","year":"2021","journal-title":"J. Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jinf.2021.12.005","article-title":"Post-sequelae one year after hospital discharge among older COVID-19 patients: A multi-center prospective cohort study","volume":"84","author":"Fang","year":"2022","journal-title":"J. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00296-020-04744-9","article-title":"COVID-19 pandemic in Japan","volume":"41","author":"Amengual","year":"2021","journal-title":"Rheumatol. Int."},{"key":"ref_32","unstructured":"Centers for Disease Control and Prevention (CDC) (2022, October 24). Long COVID or Post-COVID Conditions, Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/long-term-effects\/index.html."},{"key":"ref_33","unstructured":"The Yomiuri Shimbun (2022, March 02). Year-End Retrospective. Available online: https:\/\/www.yomiuri.co.jp\/local\/aichi\/news\/20211228-OYTNT50095\/."},{"key":"ref_34","unstructured":"Masuda, M. (2022, March 02). SARS-CoV-2: Where They Came From and Where They\u2019re Going. Available online: https:\/\/www.covid19-jma-medical-expert-meeting.jp\/topic\/7111."},{"key":"ref_35","unstructured":"National Institute of Infectious Diseases, Japan (2022, March 03). Molecular Epidemiological Study of SARS-CoV-2, Using Genomic Information, Available online: https:\/\/www.niid.go.jp\/niid\/ja\/diseases\/kdcorona-virus\/2019-ncov\/2488-idsc\/iasr-news\/10152-493p01.html."},{"key":"ref_36","unstructured":"World Health Organization (WHO) (2022, March 03). Tracking SARS-CoV-2 Variants. Available online: https:\/\/www.who.int\/en\/activities\/tracking-SARS-CoV-2-variants."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1440-1819.2009.01954.x","article-title":"A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders","volume":"63","author":"Matsuda","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2021.03.023","article-title":"Skewing of the B cell receptor repertoire in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"95","author":"Sato","year":"2021","journal-title":"Brain Behav. Immun."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/21\/6457\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:06:31Z","timestamp":1760144791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/21\/6457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":38,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jcm11216457"],"URL":"https:\/\/doi.org\/10.3390\/jcm11216457","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]}}}