{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:04:48Z","timestamp":1784675088709,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"\u00b5BONE (SPP2084)","doi-asserted-by":"publisher","award":["EB 447\/10-1"],"award-info":[{"award-number":["EB 447\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"\u00b5BONE (SPP2084)","doi-asserted-by":"publisher","award":["HO 5109\/2-1"],"award-info":[{"award-number":["HO 5109\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"\u00b5BONE (SPP2084)","doi-asserted-by":"publisher","award":["HO 5109\/2-2"],"award-info":[{"award-number":["HO 5109\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"\u00b5BONE (SPP2084)","doi-asserted-by":"publisher","award":["D-361"],"award-info":[{"award-number":["D-361"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["EB 447\/10-1"],"award-info":[{"award-number":["EB 447\/10-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["HO 5109\/2-1"],"award-info":[{"award-number":["HO 5109\/2-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["HO 5109\/2-2"],"award-info":[{"award-number":["HO 5109\/2-2"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["D-361"],"award-info":[{"award-number":["D-361"]}]},{"name":"Graduate School of Life Sciences, University of Wuerzburg","award":["EB 447\/10-1"],"award-info":[{"award-number":["EB 447\/10-1"]}]},{"name":"Graduate School of Life Sciences, University of Wuerzburg","award":["HO 5109\/2-1"],"award-info":[{"award-number":["HO 5109\/2-1"]}]},{"name":"Graduate School of Life Sciences, University of Wuerzburg","award":["HO 5109\/2-2"],"award-info":[{"award-number":["HO 5109\/2-2"]}]},{"name":"Graduate School of Life Sciences, University of Wuerzburg","award":["D-361"],"award-info":[{"award-number":["D-361"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) at the University of Wuerzburg","award":["EB 447\/10-1"],"award-info":[{"award-number":["EB 447\/10-1"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) at the University of Wuerzburg","award":["HO 5109\/2-1"],"award-info":[{"award-number":["HO 5109\/2-1"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) at the University of Wuerzburg","award":["HO 5109\/2-2"],"award-info":[{"award-number":["HO 5109\/2-2"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) at the University of Wuerzburg","award":["D-361"],"award-info":[{"award-number":["D-361"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Active vitamin D (1,25(OH)2D3) is known to exert direct anti-cancer actions on various malignant tissues through binding to the vitamin D receptor (VDR). These effects have been demonstrated in breast, prostate, renal and thyroid cancers, which all have a high propensity to metastasise to bone. In addition, there is evidence that vitamin D catabolism via 24-hydroxylase (CYP24A1) is altered in tumour cells, thus, reducing local active vitamin D levels in cancer cells. The aim of this study was to assess VDR and CYP24A1 expression in various types of bone metastases by using immunohistochemistry. Overall, a high total VDR protein expression was detected in 59% of cases (39\/66). There was a non-significant trend of high-grade tumours towards the low nuclear VDR expression (p = 0.07). Notably, patients with further distant metastases had a reduced nuclear VDR expression (p = 0.03). Furthermore, a high CYP24A1 expression was detected in 59% (39\/66) of bone metastases. There was a significant positive correlation between nuclear VDR and CYP24A1 expression (p = 0.001). Collectively, the VDR and CYP24A1 were widely expressed in a multitude of bone metastases, pointing to a potential role of vitamin D signalling in cancer progression. This is of high clinical relevance, as vitamin D deficiency is frequent in patients with bone metastases.<\/jats:p>","DOI":"10.3390\/jcm11216537","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"6537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bone Metastases of Diverse Primary Origin Frequently Express the VDR (Vitamin D Receptor) and CYP24A1"],"prefix":"10.3390","volume":"11","author":[{"given":"Jonas","family":"Seiler","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Tissue Regeneration, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-869X","authenticated-orcid":false,"given":"Regina","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Tissue Regeneration, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-6594","authenticated-orcid":false,"given":"Maximilian","family":"Rudert","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-7474","authenticated-orcid":false,"given":"Marietta","family":"Herrmann","sequence":"additional","affiliation":[{"name":"IZKF Research Group Tissue Regeneration in Musculoskeletal Diseases, University Clinics W\u00fcrzburg, 97070 Wuerzburg, Germany"},{"name":"Orthopaedic Center for Musculoskeletal Research, University of W\u00fcrzburg, 97074 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Leich","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wuerzburg, 97070 Wuerzburg, Germany"},{"name":"Comprehensive Cancer Center Mainfranken, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Wei\u00dfenberger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Caritas Hospital Bad Mergentheim, 97980 Bad Mergentheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-3541","authenticated-orcid":false,"given":"Konstantin","family":"Horas","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Tissue Regeneration, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"},{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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