{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:17:07Z","timestamp":1762273027031,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research (DSR), King Abdulaziz University, Saudi Arabia","award":["RG: 22-130-40"],"award-info":[{"award-number":["RG: 22-130-40"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Vitamin D has been traditionally seen to be mainly involved in the regulation of bone homeostasis. However, vitamin D has also been clinically linked to various diseases, including metabolic syndrome. The aim of this study was to examine the effect of low and high doses of a vitamin D supplement on the serum levels of 25(OH)D3 and insulin resistance. A total of 120 females were recruited in this study and supplemented weekly with 25,000 IU vitamin D or 50,000 IU vitamin D for three months. Anthropometric measurements were taken at the beginning of the study. Blood samples were collected at the beginning of the study to determine the baseline of the clinical variables and collected again after three months. Insulin resistance was measured using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). After vitamin D supplementation, a non-significant increase was observed in the serum levels of 25(OH)D3 in the group treated with a low dose of vitamin D (LDVD) and a highly significant increase was seen in the group treated with a high dose of vitamin D (HDVD). In the group treated with a higher dose (HDVD), a significant improvement in insulin sensitivity was observed. The high dose of vitamin D (50,000 IU) supplementation was more effective in both correcting the blood levels of vitamin D and improving the sensitivity of insulin.<\/jats:p>","DOI":"10.3390\/jcm11216577","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:11:00Z","timestamp":1667909460000},"page":"6577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A High Dose, Not Low Dose, of Vitamin D Ameliorates Insulin Resistance in Saudi Women"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-6116","authenticated-orcid":false,"given":"Shareefa","family":"AlGhamdi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 23623, Saudi Arabia"},{"name":"Vitamin D Pharmacogenomics Research Group, King Abdulaziz University, Jeddah 23623, Saudi Arabia"},{"name":"Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 23623, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"AlHarthi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 23623, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan","family":"Khoja","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 23623, Saudi Arabia"},{"name":"Vitamin D Pharmacogenomics Research Group, King Abdulaziz University, Jeddah 23623, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"AlJefri","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah 23623, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-8844","authenticated-orcid":false,"given":"Huda F.","family":"AlShaibi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 23623, Saudi Arabia"},{"name":"Embryonic Stem Cell Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 23623, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"ref_1","unstructured":"Sizar, O., Khare, S., Goyal, A., and Givler, A. 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