{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T02:06:47Z","timestamp":1761790007922,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taichung Veterans General Hospital","award":["TCVGH-1077329D","TCVGH-1077311C","TYVH-10808","TYVH-10809","TYVH-10902"],"award-info":[{"award-number":["TCVGH-1077329D","TCVGH-1077311C","TYVH-10808","TYVH-10809","TYVH-10902"]}]},{"name":"Taipei Veterans General Hospital","award":["TCVGH-1077329D","TCVGH-1077311C","TYVH-10808","TYVH-10809","TYVH-10902"],"award-info":[{"award-number":["TCVGH-1077329D","TCVGH-1077311C","TYVH-10808","TYVH-10809","TYVH-10902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>End-stage renal disease (ESRD) patients on long-term hemodialysis (HD) have an elevated risk of sudden cardiac death. This study hypothesizes, for the first time, that these patients have a higher odds of return of spontaneous circulation (ROSC) and subsequent better hospital-outcomes, post out-of-hospital cardiac arrest (OHCA), as opposed to non-ESRD patients. A national database from Taiwan was utilized, in which 101,876 ESRD patients undergoing HD and propensity score-matched non-ESRD patients were used to conduct two analyses: (i) Cox-proportional-hazards-regression for OHCA incidence and (ii) logistic-regression analysis of attaining ROSC after OHCA, both for ESRD patients in comparison to non-ESRD patients. Kaplan-Meier analyses were conducted to determine the difference of survival rates after ROSC between the two cohorts. ESRD patients were found to be at a higher risk of OHCA (adjusted-HR = 2.11, 95% CI: (1.89\u20132.36), p &lt; 0.001); however, they were at higher odds of attaining ROSC (adjusted-OR = 2.47, 95% CI: 1.90\u20133.21, p &lt; 0.001), as opposed to non-ESRDs. Further, Kaplan-Meier analysis demonstrated ESRD patients with a better 30-day hospital survival rate than non-ESRD patients. Although ESRD patients had a higher risk of OHCA, they demonstrated higher possibility of ROSC and a better short-term hospital outcome than non-ESRDs. Chronic toxin tolerance and the training of vascular-compliance during regular HD may be possible explanations for better outcomes in ESRD patients.<\/jats:p>","DOI":"10.3390\/jcm11216582","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:11:00Z","timestamp":1667909460000},"page":"6582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["End-Stage Renal Disease Patients Undergoing Hemodialysis Have Higher Possibility of Return of Spontaneous Circulation during Out-of-Hospital Cardiac Arrest and Non-Inferior Short-Term Survival"],"prefix":"10.3390","volume":"11","author":[{"given":"Ming-Shun","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"},{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Center for Translational Genomics and Regenerative Medicine, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-0386","authenticated-orcid":false,"given":"Tzu-Pin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Public Health, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 100, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-En","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-0897","authenticated-orcid":false,"given":"Vivian Chia-Rong","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Health Services Administration, China Medical University, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Yuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-0797","authenticated-orcid":false,"given":"Chorng-Kuang","family":"How","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0300-9572(01)00381-1","article-title":"Spontaneous subarachnoid haemorrhage as a cause of out-of-hospital cardiac 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