{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:00:00Z","timestamp":1762074000806,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Polyhydramnios represents a complication found in 0.2\u20132% of pregnancies, and it is usually diagnosed between 31 and 36 weeks of pregnancy. Although most cases of polyhydramnios are idiopathic, maternal diabetes or foetal malformations constitute frequent causes of the excessive accumulation of the amniotic fluid. Considering the latter, polyhydramnios may rarely be caused by foetal abdominal tumours, with the incidence rate of 2\u201314 cases per 100,000 live births. Congenital neonatal leukaemia (CNL) is a rare disease with a reported incidence rate of 5\u20138.6 cases per million live births. In the prenatal period, the ultrasound abnormalities associated with CNL include hepatomegaly and splenomegaly. In this paper, we presented a case of polyhydramnios caused by mechanical pressure on the foetal gastrointestinal tract by an enlarged lymph node in the course of CNL, as well as reviewing the available literature on foetal abdominal tumours with concurrent polyhydramnios.<\/jats:p>","DOI":"10.3390\/jcm11216598","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:53:52Z","timestamp":1667904832000},"page":"6598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enlarged Abdominal Lymph Node as a Cause of Polyhydramnios in the Course of Congenital Neonatal Leukaemia: A Case Report and Review of the Literature on Foetal Abdominal Tumours with Coexisting Polyhydramnios"],"prefix":"10.3390","volume":"11","author":[{"given":"Daria","family":"Salloum","sequence":"first","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-7546","authenticated-orcid":false,"given":"Pawe\u0142 Jan","family":"Stanirowski","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Symonides","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Krajewski","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Bomba-Opo\u0144","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-3668","authenticated-orcid":false,"given":"Miros\u0142aw","family":"Wielgo\u015b","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1\/3, 02-015 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0002-9378(99)70084-0","article-title":"Idiopathic polyhydramnios and perinatal outcome","volume":"181","author":"Nguyen","year":"1999","journal-title":"Am. J. Obstet Gynecol."},{"key":"ref_2","first-page":"540","article-title":"Amniotic fluid volume assessment with the four-quadrant technique at 36-42 weeks\u2019 gestation","volume":"32","author":"Phelan","year":"1987","journal-title":"J. Reprod. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1573396311666150714105727","article-title":"Perinatal Management of Fetal Tumors","volume":"11","author":"Peiro","year":"2015","journal-title":"Curr. Pediatr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/MOP.0b013e32835c1d71","article-title":"Perinatal management of infant tumors and the promise of fetal surgery","volume":"25","author":"Bruny","year":"2013","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/jcp.2003.12039","article-title":"Demographic study of leukaemia presenting within the first 3 months of life in the Northern Health Region of England","volume":"57","author":"Bajwa","year":"2004","journal-title":"J. Clin. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1177\/0300060519872899","article-title":"Analysis of 59 cases of congenital leukemia reported between 2001 and 2016","volume":"47","author":"Zhang","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/00043426-200305000-00002","article-title":"Fetal and Neonatal Leukemia","volume":"25","author":"Isaacs","year":"2003","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/uog.87","article-title":"Prenatal diagnosis of congenital leukemia in a fetus at 25 weeks\u2019 gestation with Down syndrome: Case report and review of the literature","volume":"21","author":"Robertson","year":"2003","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2007-1004826","article-title":"Fetal Hydrops Associated with Tumors","volume":"25","author":"Isaacs","year":"2008","journal-title":"Am. J. Perinatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2141.2002.03459.x","article-title":"Congenital leukaemia: The Dutch experience and review of the literature","volume":"117","author":"Bresters","year":"2002","journal-title":"Br. J. Haematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.5603\/GP.2020.0110","article-title":"Practice guidelines of the Polish Society of Gynecologists and Obstetricians\u2014Ultrasound Section for ultrasound screening in uncomplicated pregnancy\u20142020","volume":"91","author":"Borowski","year":"2020","journal-title":"Ginekol. Pol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1111\/jog.14768","article-title":"Case of fetal ovarian juvenile granulosa cell tumor: Complications and management","volume":"47","author":"Sela","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.ANC.0000311012.63887.fb","article-title":"Infantile myofibroma: A case report and review of the literature","volume":"8","author":"Schurr","year":"2008","journal-title":"Adv. Neonatal. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/08880018.2010.496896","article-title":"Neuroblastoma presented with polyhydramniosis","volume":"28","author":"Guliyev","year":"2011","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/jcu.22451","article-title":"Metastatic neuroblastoma diagnosed on prenatal sonographic examination performed for decreased fetal movement","volume":"45","author":"Chapa","year":"2017","journal-title":"J. Clin. Ultrasound."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/uog.2623","article-title":"Prenatal diagnosis of fetal bilateral adrenal carcinoma","volume":"26","author":"Izbizky","year":"2005","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000212057","article-title":"Mesenchymal hamartoma of the liver: A benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature","volume":"25","author":"Cornette","year":"2009","journal-title":"Fetal Diagn Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0028-2243(85)90085-1","article-title":"Acute polyhydramnios associated with fetal hepatoblastoma","volume":"20","author":"Verwey","year":"1985","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1469-0705.2000.00169.x","article-title":"Prenatal diagnosis of congenital Wilms\u2019 tumor (nephroblastoma) presenting as fetal hydrops","volume":"16","author":"Vadeyar","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/pd.1970050210","article-title":"Prenatal diagnosis and perinatal management of a fetal ovarian cyst","volume":"5","author":"Holzgreve","year":"1985","journal-title":"Prenat Diagn"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-2003-39560","article-title":"Congenital fibrosarcoma of the jejunum in a premature infant with meconium peritonitis","volume":"13","author":"Shima","year":"2003","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.5468\/ogs.2015.58.5.405","article-title":"Prenatal diagnosis of congenital mesoblastic nephroma","volume":"58","author":"Do","year":"2015","journal-title":"Obstet. Gynecol. Sci."},{"doi-asserted-by":"crossref","unstructured":"Kato, H., Mitani, Y., Goda, T., and Yamaue, H. (2022). Neonatal congenital mesoblastic nephroma that caused respiratory oncologic emergency early after birth: A case report. BMC Pediatr., 22.","key":"ref_23","DOI":"10.1186\/s12887-022-03817-x"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/2230-8229.97054","article-title":"Congenital mesoblastic nephroma: A case report","volume":"15","year":"2008","journal-title":"J. Family Community Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00467-001-0779-9","article-title":"Congenital mesoblastic nephroma associated with polyhydramnios and hypercalcemia","volume":"17","author":"Daskas","year":"2002","journal-title":"Pediatr. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e24034","DOI":"10.1097\/MD.0000000000024034","article-title":"Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging","volume":"100","author":"Che","year":"2021","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e230297","DOI":"10.1136\/bcr-2019-230297","article-title":"Prenatal diagnosis of congenital mesoblastic nephroma: A case with poor prognosis","volume":"12","author":"Mata","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/pd.727","article-title":"Prenatal diagnosis of congenital mesoblastic nephroma in mid-second trimester by sonography and magnetic resonance imaging","volume":"23","author":"Chen","year":"2003","journal-title":"Prenat. Diagn."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/pd.5942","article-title":"Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China","volume":"41","author":"Chen","year":"2021","journal-title":"Prenat. Diagn."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1001\/jama.1978.03290140046020","article-title":"Congenital mesoblastic nephroma and polyhydramnios","volume":"240","author":"Blank","year":"1978","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101336","DOI":"10.1016\/j.epsc.2019.101336","article-title":"Congenital mesoblastic nephroma: Case study","volume":"55","author":"Kimani","year":"2020","journal-title":"J. Pediatr. Surg. Case Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1891\/0730-0832.36.1.32","article-title":"Congenital Mesoblastic Nephroma Presenting with Refractory Hypertension in a Premature Neonate: A Case Study","volume":"36","author":"Newberry","year":"2017","journal-title":"Neonatal Netw."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/8756479320908228","article-title":"Prenatal Diagnosis of a Cyst of the Canal of Nuck Associated with an Ovarian Cyst and Acute Polyhydramnios","volume":"36","author":"Allen","year":"2020","journal-title":"J. Diagn. Med. Sonogr."},{"doi-asserted-by":"crossref","unstructured":"Caballes, A.B., Dungca, L.B.P., Uy, M.E.V., Torralba, M.G.C., and Embuscado, C.M.G. (2020). Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: A case report. BMC Pediatr., 20.","key":"ref_34","DOI":"10.1186\/s12887-020-02090-0"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ajmg.1320380113","article-title":"Congenital gastric teratoma in Wiedemann-Beckwith syndrome","volume":"38","author":"Falikborenstein","year":"1991","journal-title":"Am. J. Med. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1447-0756.2011.01728.x","article-title":"Rapidly grown congenital fetal immature gastric teratoma causing severe neonatal respiratory distress","volume":"38","author":"Jeong","year":"2012","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_37","first-page":"193","article-title":"Beckwith-Wiedemann syndrome\u2014A rare case report","volume":"21","author":"Arora","year":"2019","journal-title":"JK Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ajmg.1320240112","article-title":"The Perlman familial nephroblastomatosis syndrome","volume":"24","author":"Greenberg","year":"1986","journal-title":"Am. J. Med. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0146-0005(99)80036-6","article-title":"Congenital and neonatal leukemia","volume":"23","author":"Sande","year":"1999","journal-title":"Semin. Perinatol."},{"key":"ref_40","first-page":"608","article-title":"Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children\u2019s Cancer Group Studies 2861 and 2891","volume":"91","author":"Lange","year":"1998","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000323582","article-title":"Prenatal Findings in Congenital Leukemia: A Case Report","volume":"29","author":"Sato","year":"2011","journal-title":"Fetal Diagn Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0046-8177(89)90156-1","article-title":"Classical and cellular (atypical) congenital mesoblastic nephroma: A clinicopathologic, ultrastructural, immunohistochemical, and flow cytometric study","volume":"20","author":"Pettinato","year":"1989","journal-title":"Hum. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00383-006-1831-4","article-title":"Atypical congenital mesoblastic nephroma presenting in the perinatal period","volume":"23","author":"Jones","year":"2007","journal-title":"Pediatr. Surg. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.earlhumdev.2010.08.018","article-title":"Neonatal renal tumours","volume":"86","author":"Powis","year":"2010","journal-title":"Early Hum. Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e716","DOI":"10.1542\/neo.21-11-e716","article-title":"Congenital neuroblastoma","volume":"21","author":"Minakova","year":"2020","journal-title":"Neoreviews"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1111\/jdv.13049","article-title":"Neonatal leukaemia cutis","volume":"29","author":"Handler","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000020888","article-title":"Prenatal diagnosis of congenital neuroblastoma. Analysis of 4 cases and review of the literature","volume":"14","author":"Heling","year":"1999","journal-title":"Fetal Diagn Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00001703-199404000-00015","article-title":"Diagnosis and management of fetal neuroblastoma","volume":"6","author":"Crombleholme","year":"1994","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15513810701696890","article-title":"Fetal and neonatal neuroblastoma: Retrospective review of 271 cases","volume":"26","author":"Isaacs","year":"2007","journal-title":"Fetal. Pediatr. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/978-1-4419-6448-9_18","article-title":"Wilms\u2019 tumor","volume":"685","author":"Dave","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.21037\/tp-20-440","article-title":"Fetal abdominal tumors and cysts","volume":"10","author":"Cass","year":"2021","journal-title":"Translational Pediatrics."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00247-019-04423-3","article-title":"Imaging of Wilms tumor: An update","volume":"49","author":"Servaes","year":"2019","journal-title":"Pediatr. Radiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/21\/6598\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:08Z","timestamp":1760145128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/21\/6598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":52,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jcm11216598"],"URL":"https:\/\/doi.org\/10.3390\/jcm11216598","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,11,7]]}}}