{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:32:31Z","timestamp":1789651951312,"version":"4.0.0"},"reference-count":36,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea University Ansan Hospital","award":["k2212101"],"award-info":[{"award-number":["k2212101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Predicting the development of hepatocellular carcinoma (HCC) is a key clinical issue in patients with chronic hepatitis B (CHB). The aim of this study was to develop a precise and simple HCC risk score for up to 10 years. A total of 1895 CHB patients treated with entecavir or tenofovir disoproxil fumarate were retrospectively recruited and randomized into derivation (n = 1239) and validation cohorts (n = 656). Variables proven to be independent risk factors for HCC in the derivation cohort were used to develop the prediction model. The ACCESS-HCC model included five variables (age, cirrhosis, consumption of ethanol, liver stiffness, and serum alanine aminotransferase). Areas under curves were 0.798, 0.762, and 0.883 for HCC risk at 3, 5, and 10 years, respectively, which were higher than those of other prediction models. The scores were categorized according to significantly different HCC incidences: 0\u20134, low; 5\u20138, intermediate; and 9\u201314, high-risk. The annual incidence rates were 0.5%, 3.2%, and 11.3%, respectively. The performance of this model was validated in an independent cohort. The ACCESS-HCC model shows improved long-term prediction and provides three distinct risk categories for HCC in CHB patients receiving antiviral therapy. Further research is needed for external validation using larger cohorts.<\/jats:p>","DOI":"10.3390\/jcm11226613","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:53:52Z","timestamp":1667904832000},"page":"6613","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Prediction Model for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Receiving Antiviral Therapy: Based on Data from Korean Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-435X","authenticated-orcid":false,"given":"Ji Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Kak","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hee","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University College of Medicine, Seoul 01757, Korea"},{"name":"Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-4293","authenticated-orcid":false,"given":"Tae Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joon","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-5974","authenticated-orcid":false,"given":"Sun Young","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6396-0859","authenticated-orcid":false,"given":"Young-Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kul","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-0434","authenticated-orcid":false,"given":"Ji Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-7371","authenticated-orcid":false,"given":"Jong Eun","family":"Yeon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Sang","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Ho","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University College of Medicine, Seoul 02841, Korea"},{"name":"Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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