{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:41:49Z","timestamp":1760244109764,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This retrospective cohort study evaluated pregnancy outcomes and similarities between pairs of nulliparous sisters with a singleton fetus who delivered between 2013 and 2020. The \u201cSister-1 group\u201d was defined as the sibling who delivered first, while the \u201cSister-2 group\u201d included the siblings who gave birth after Sister-1. Obstetrical complications and delivery outcomes were compared. The relative risk for recurrence of a complication in Sister-2 was calculated. The study included 743 sister pairs. There were no between-group differences in maternal BMI, gestational age at delivery, gravidity, smoking, or epidural rates. The Sister-2 group was older than the Sister-1 group (26.4 \u00b1 5 vs. 25.8 \u00b1 4.7 years, respectively, p = 0.05). Higher birthweights and more large-for-gestational-age infants characterized the Sister-2 group compared with the Sister-1 group (3241 \u00b1 485 g vs. 3148 \u00b1 536 g, p &lt; 0.001 and 7.7% vs. 4.8%, p = 0.025, respectively). There were no between-group differences in the rate of small-for-gestational-age, gestational diabetes, hypertensive disorders, pre-term births, vacuum extraction, or cesarean deliveries. Logistic regression analysis found that if Sister-1 underwent vacuum extraction, her sibling had an increased risk for vacuum delivery (adjusted RR 3.03, 95% CI 1.4\u20136.7; p = 0.003) compared with those whose sibling (Sister-1) did not. There was a three-fold risk of vacuum extraction delivery between sisters. This finding could be related to biological inheritance, environmental factors, and\/or psychological issues that may affect similarities between siblings\u2019 delivery outcomes.<\/jats:p>","DOI":"10.3390\/jcm11226713","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T04:24:10Z","timestamp":1668399850000},"page":"6713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are There Similarities in Pregnancy Complications and Delivery Outcomes among Sisters?"],"prefix":"10.3390","volume":"11","author":[{"given":"Hila","family":"Shalev-Ram","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-0532","authenticated-orcid":false,"given":"Gal","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"},{"name":"Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Heresco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-0813","authenticated-orcid":false,"given":"Hanoch","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Biron-Shental","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kovo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-7660","authenticated-orcid":false,"given":"Dorit","family":"Ravid","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/bmj.38555.462685.8F","article-title":"Recurrence of pre-eclampsia across generations: Exploring fetal and maternal genetic components in a population based cohort","volume":"331","author":"Vatten","year":"2005","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/j.1471-0528.2011.03154.x","article-title":"Recurrence of prolonged and post-term gestational age across generations: Maternal and paternal contribution","volume":"118","author":"Morken","year":"2011","journal-title":"BJOG"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ije\/28.2.253","article-title":"Recurrence of prolonged pregnancy","volume":"28","author":"Mogren","year":"1999","journal-title":"Int. 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Health"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6713\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:18Z","timestamp":1760145438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,13]]},"references-count":16,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jcm11226713"],"URL":"https:\/\/doi.org\/10.3390\/jcm11226713","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,11,13]]}}}