{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:24:10Z","timestamp":1772767450744,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Our aim was to assess the opinion of a panel of experts and obtain a consensus on the management of endometrial cancer in France and French Switzerland. A Delphi survey was carried out among a panel of French and French-speaking Swiss experts. The first questionnaire included 65 questions divided into eight categories: characterization of experts, histo-molecular characteristics and radiological data of endometrial cancer, and management of low-risk, intermediate-risk, intermediate\u2013high-risk, high-risk, and metastatic cancers. The experts were asked to reply on a 9-point scale, both on the validity and the clarity of each question. After the answers were analyzed, a second questionnaire was sent to the same experts. The study took place between December 2021 and March 2022. Further, 58 (57.4%) of the 101 experts responded in the first round, and 39 recommendations were obtained (60%). Six questions were voted redundant and 20 discordant. These questions were reformulated, and, at the end of the second round, 17 recommendations were validated (85%). In total, the study presents an analysis of 56 questions and related responses. Expert advice helps to clarify non-consensual issues, standardize the management of endometrial cancer, and optimize clinical practices.<\/jats:p>","DOI":"10.3390\/jcm11226765","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:36:36Z","timestamp":1668566196000},"page":"6765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Management of Endometrial Cancer: French Society of Onco-Gynecology\u2018s Evaluation through a Delphi Survey"],"prefix":"10.3390","volume":"11","author":[{"given":"Carolin","family":"Marti","sequence":"first","affiliation":[{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL), 1015 Lausanne, Switzerland"},{"name":"Department of Gynecology and Obstetrics, HFR Fribourg-H\u00f4pital Cantonal, 1708 Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Deluche","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, CHU Limoges, 87000 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriane","family":"Jochum","sequence":"additional","affiliation":[{"name":"Residual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, University Paris, 75005 Paris, France"},{"name":"Department of Gynecology and Obstetrics, Hopitaux Universitaires de Strasbourg, 67091 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofiane","family":"Bendifallah","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Tenon Hospital, 75020 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-9754","authenticated-orcid":false,"given":"Henri","family":"Azais","sequence":"additional","affiliation":[{"name":"Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Deidier","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Universitaire Paris Ouest Site G Pompidou APHP, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-4436","authenticated-orcid":false,"given":"Vincent","family":"Cockenpot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre L\u00e9on B\u00e9rard, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e8s","family":"Menoux","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, ICANS-Strasbourg-Europe Cancer Institute, 67200 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-239X","authenticated-orcid":false,"given":"Vincent","family":"Balaya","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Foch Hospital, 92150 Suresnes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Betrian","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IUCT Oncopole, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3695","authenticated-orcid":false,"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, 94850 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Gouy","sequence":"additional","affiliation":[{"name":"Department of Surgical Gynecology Oncology, Gustave Roussy Cancer Campus, 94850 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Genestie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gustave Roussy Cancer Campus, 94850 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9445","authenticated-orcid":false,"given":"Anis","family":"Feki","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, HFR Fribourg-H\u00f4pital Cantonal, 1708 Fribourg, Switzerland"},{"name":"Faculty of Science and Medicine, University of Fribourg (UNIFR), 1700 Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Uzan","sequence":"additional","affiliation":[{"name":"Departement of Breast and Gynecologic Surgery, AP\u2013HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, 75013 Paris, France"},{"name":"Institut Universitaire de Canc\u00e9rologie, Sorbonne Universit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Guyon","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Bergoni\u00e9 Institute, 33076 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojgan","family":"Devouassoux-Shisheboran","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospices Civiles de Lyon, 69002 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Body","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut de Canc\u00e9rologie de l\u2019Ouest (ICO), 49055 Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherif","family":"Akladios","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hopitaux Universitaires de Strasbourg, 67091 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Mathevet","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL), 1015 Lausanne, Switzerland"},{"name":"Department of Gynecology and Obstetrics, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-3734","authenticated-orcid":false,"given":"Benedetta","family":"Guani","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL), 1015 Lausanne, Switzerland"},{"name":"Department of Gynecology and Obstetrics, HFR Fribourg-H\u00f4pital Cantonal, 1708 Fribourg, Switzerland"},{"name":"Faculty of Science and Medicine, University of Fribourg (UNIFR), 1700 Fribourg, Switzerland"},{"name":"Department of Gynecology and Obstetrics, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the SFOG and the SFOG Campus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"(2022, June 29). Estimations Nationales de L\u2019incidence et de la Mortalit\u00e9 par Cancer en France M\u00e9tropolitaine Entre 1990 et 2018\u2014Tumeurs Solides : \u00c9tude \u00e0 Partir des Registres des Cancers du R\u00e9seau Francim. Available online: https:\/\/www.santepubliquefrance.fr\/maladies-et-traumatismes\/cancers\/cancer-du-sein\/documents\/rapport-synthese\/estimations-nationales-de-l-incidence-et-de-la-mortalite-par-cancer-en-france-metropolitaine-entre-1990-et-2018-volume-1-tumeurs-solides-etud."},{"key":"ref_3","unstructured":"World Health Organization (2021, June 29). GLOBOCAN 2018: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2020. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/24-Corpus-uteri-fact-sheet.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO\u2013ESGO\u2013ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-Up","volume":"27","author":"Colombo","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_6","first-page":"458","article-title":"An experimental application of the Delphi method to the use of experts","volume":"6","author":"Dalkey","year":"1959","journal-title":"Manag. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5662\/wjm.v11.i4.116","article-title":"Delphi methodology in healthcare research: How to decide its appropriateness","volume":"11","author":"Nasa","year":"2021","journal-title":"World J. Methodol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/bmj.311.7001.376","article-title":"Consensus methods for medical and health services research","volume":"311","author":"Jones","year":"1995","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/jmri.1121","article-title":"Staging endometrial cancer: Role of magnetic resonance imaging","volume":"13","author":"Frei","year":"2001","journal-title":"J. Magn. Reason. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.21873\/anticanres.13155","article-title":"Para-aortic Lymph Node Invasion in High-risk Endometrial Cancer: Performance of 18FDG PET-CT","volume":"39","author":"Legros","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e12522","DOI":"10.1097\/MD.0000000000012522","article-title":"The diagnostic accuracy of fluorodeoxyglucose-positron emission tomography\/computed tomography and sentinel node biopsy in the prediction of pelvic lymph node metastasis in patients with endometrial cancer: A retrospective observational study","volume":"97","author":"Tanaka","year":"2018","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.annonc.2022.05.009","article-title":"Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"33","author":"Oaknin","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1097\/PGP.0000000000000496","article-title":"International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines from the Special Techniques and Ancillary Studies Group","volume":"38","author":"Cho","year":"2019","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1093\/jnci\/djn397","article-title":"Systematic Pelvic Lymphadenectomy vs No Lymphadenectomy in Early-Stage Endometrial Carcinoma: Randomized Clinical Trial","volume":"100","author":"Panici","year":"2008","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_15","first-page":"125","article-title":"Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study","volume":"373","author":"Kitchener","year":"2008","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S1470-2045(17)30068-2","article-title":"A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): A multicentre, prospective, cohort study","volume":"18","author":"Rossi","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ygyno.2017.05.016","article-title":"A prospective validation study of sentinel lymph node mapping for high-risk endometrial cancer","volume":"146","author":"Soliman","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jamasurg.2020.5060","article-title":"Assessment of Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging","volume":"156","author":"Cusimano","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2019.04.025","article-title":"Pelvic Sentinel lymph node detection in High-Risk Endometrial Cancer (SHREC-trial)\u2014The final step towards a paradigm shift in surgical staging","volume":"116","author":"Persson","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ygyno.2019.03.254","article-title":"Sentinel node mapping vs. lymphadenectomy in endometrial cancer: A systematic review and meta-analysis","volume":"153","author":"Bogani","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1470-2045(18)30079-2","article-title":"Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): Final results of an international, open-label, multicentre, randomised, phase 3 trial","volume":"19","author":"Powell","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1200\/JCO.20.00549","article-title":"Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy","volume":"38","author":"Powell","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41379-022-01102-x","article-title":"p53 immunohistochemistry in endometrial cancer: Clinical and molecular correlates in the PORTEC-3 trial","volume":"35","author":"Vermij","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/path.5375","article-title":"p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies","volume":"250","author":"Singh","year":"2020","journal-title":"J. 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