{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:39:39Z","timestamp":1780457979419,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia in Katowice","award":["KNW-1-054\/N\/9\/K"],"award-info":[{"award-number":["KNW-1-054\/N\/9\/K"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this study was to assess the relationship between the results of the objective assessment of the vestibular organ in patients with peripheral vertigo with Hashimoto\u2019s thyroiditis and thyroid hormone metabolism. Twenty eight women with Hashimoto\u2019s thyroiditis and chronic vertigo were enrolled in the study. Patients underwent audiological assessment of hearing, Dix\u2013Hallpike test, videonystagmography with caloric test, head impulse test (HIT) and cervical vestibular-evoked myogenic potentials (cVEMPs). Levels of thyroid hormones and anti-thyroid antibodies were determined. Relationships between age, weight, height, BMI and the results of the objective assessment of the vestibular organ were calculated. The mean age in the study group was 48 years, while the mean BMI was 26.425. The causes of peripheral vertigo in the study group were benign paroxysmal positional vertigo (BPPV) (n = 19), Meniere\u2019s disease (n = 7) and vestibular neuronitis (n = 2). No correlation was found between age, weight, height, BMI and the results of thyroid function tests or the objective assessment of the vestibular organ. The study did not confirm the influence of thyroid metabolism (i.e., thyroid hormone levels or the increase in antithyroid antibodies) on the results of cVEMP or the directional preponderance in the caloric test.<\/jats:p>","DOI":"10.3390\/jcm11226771","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:36:36Z","timestamp":1668566196000},"page":"6771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does Thyroid Hormone Metabolism Correlate with the Objective Assessment of the Vestibular Organ in Patients with Vertigo?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-3437","authenticated-orcid":false,"given":"Katarzyna","family":"Mi\u015bkiewicz-Orczyk","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Laryngological Oncology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanas","family":"Vlaykov","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Lisowska","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Laryngological Oncology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kos-Kud\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","first-page":"173","article-title":"Diagnosis and treatment of vertigo and dizziness","volume":"105","author":"Strupp","year":"2008","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-444-63437-5.00005-4","article-title":"The epidemiology of dizziness and vertigo","volume":"137","author":"Neuhauser","year":"2016","journal-title":"Handb. Clin. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"743379","DOI":"10.3389\/fneur.2021.743379","article-title":"Editorial: Epidemiology and Genetics of Vestibular Disorders","volume":"12","author":"Cheng","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/STROKEAHA.108.192218","article-title":"The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists","volume":"40","author":"Easton","year":"2009","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/0145561319871234","article-title":"Benign Paroxysmal Positional Vertigo: Comparison of Idiopathic BPPV and BPPV Secondary to Vestibular Neuritis","volume":"100","author":"Akpinar","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_6","first-page":"1","article-title":"Clinical practice guideline: Benign paroxysmal positional vertigo (update)","volume":"156","author":"Bhattacharyya","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00415-020-10314-7","article-title":"Update on benign paroxysmal positional vertigo","volume":"268","author":"Kim","year":"2021","journal-title":"J. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/0194599816628524","article-title":"2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of M\u00e9niere\u2019s Disease. Otolaryngol","volume":"154","author":"Goebel","year":"2016","journal-title":"Head Neck Surg."},{"key":"ref_9","first-page":"224","article-title":"Classification of M\u00e9niere\u2019s disease","volume":"14","author":"Shea","year":"1993","journal-title":"Am. J. Otol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.otorri.2015.05.005","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease. Consensus document of the B\u00e1r\u00e1ny Society, the Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society","volume":"67","author":"Carey","year":"2016","journal-title":"Acta Otorrinolaringol. Esp."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.anl.2016.07.020","article-title":"Vestibular neuritis: Involvement and long-term recovery of individual semicircular canals","volume":"44","author":"Hanschek","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0033-1354598","article-title":"Vestibular neuritis","volume":"33","author":"Jeong","year":"2013","journal-title":"Semin. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00415-011-6375-4","article-title":"Inferior vestibular neuritis","volume":"259","author":"Kim","year":"2012","journal-title":"J. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1212\/WNL.0000000000003223","article-title":"Vestibular neuritis affects both superior and inferior vestibular nerves","volume":"87","author":"Taylor","year":"2016","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0029665118001192","article-title":"Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease","volume":"78","author":"Rayman","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/019459988309100105","article-title":"Immunology of the inner ear: Response of the inner ear to antigen challenge","volume":"91","author":"Harris","year":"1983","journal-title":"Otolaryngol. Head. Neck. Surg."},{"key":"ref_17","first-page":"76","article-title":"Can Hashimoto\u2019s thyroiditis cause vertigo?","volume":"71","author":"Lisowska","year":"2020","journal-title":"Endokrynol. Pol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3109\/00016489.2015.1021932","article-title":"The relationship between benign paroxysmal positional vertigo and thyroid autoimmunity","volume":"135","author":"Sari","year":"2015","journal-title":"Acta Otolaryngol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Choi, H.G., Song, Y.S., Wee, J.H., Min, C., Yoo, D.M., and Kim, S.Y. (2021). Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Stud. Diagnostics, 11.","DOI":"10.3390\/diagnostics11020329"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/thy.2009.0319","article-title":"The association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis is not related to thyroid status","volume":"20","author":"Papi","year":"2010","journal-title":"Thyroid"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1054\/mehy.1999.0905","article-title":"A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo?","volume":"54","author":"Modugno","year":"2000","journal-title":"Med. Hypotheses"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2265.1994.tb02494.x","article-title":"Effects of thyroid status on thyroid autoimmunity expression in euthyroid and hypothyroid patients with Hashimoto\u2019s thyroiditis","volume":"40","author":"Rieu","year":"1994","journal-title":"Clin. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune thyroid disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/cei.13083","article-title":"RNA-sequencing study of peripheral blood mononuclear cells in sporadic M\u00e9ni\u00e8re\u2019s disease patients: Possible contribution of immunologic dysfunction to the development of this disorder","volume":"192","author":"Sun","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/archotol.130.2.226","article-title":"Prevalence of thyroid dysfunction in patients with M\u00e9ni\u00e8re\u2019s disease","volume":"130","author":"Brenner","year":"2004","journal-title":"Arch. Otolaryngol. Head. Neck. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bumm, P., and Schlimok, G. (1994). T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell\u2019s palsy, hearing loss, neuronitis vestibularis, and M\u00e9ni\u00e8re\u2019s disease. The Facial Nerve, Springer.","DOI":"10.1007\/978-3-642-85090-5_178"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3950\/jibiinkoka.67.10_1434","article-title":"Studies on the correlation between thyroid function and Meniere\u2019s syndrome","volume":"67","author":"Tamura","year":"1964","journal-title":"Nihon. Jibi. Inkoka. Gakkai. Kaiho."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5072582","DOI":"10.1155\/2018\/5072582","article-title":"Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment","volume":"2018","author":"Girasoli","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/AUD.0b013e3181b9640e","article-title":"The effect of age on the sinusoidal harmonic acceleration test, pseudorandom rotation test, velocity step test, caloric test, and vestibular-evoked myogenic potential test","volume":"31","author":"Maes","year":"2010","journal-title":"Ear. Hear."},{"key":"ref_30","first-page":"237","article-title":"Normative values of kinetic tests in VNG assessment","volume":"62","year":"2011","journal-title":"Med. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cnp.2019.01.005","article-title":"Vestibular evoked myogenic potentials in practice: Methods, pitfalls and clinical applications","volume":"26","author":"Rosengren","year":"2019","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jnnp.57.2.190","article-title":"Myogenic potentials generated by a click-evoked vestibulocollic reflex","volume":"57","author":"Colebatch","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrcardio.2016.174","article-title":"Thyroid hormones and cardiovascular disease","volume":"14","author":"Jabbar","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18224","DOI":"10.1038\/s41598-020-75404-y","article-title":"Association between Meniere\u2019s disease and thyroid diseases: A nested case-control study","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_35","first-page":"115","article-title":"Benign paroxysmal positional vertigo: Is hypothyroidism a risk factor for recurrence?","volume":"7","author":"Tricarico","year":"2022","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"863","DOI":"10.4158\/EP161635.RA","article-title":"Hashimoto thyroiditis and vestibular dysfunction","volume":"23","author":"Chiarella","year":"2017","journal-title":"Endocr Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/cen.12471","article-title":"Vestibular disorders in euthyroid patients with Hashimoto\u2019s thyroiditis: Role of thyroid autoimmunity","volume":"81","author":"Chiarella","year":"2014","journal-title":"Clin. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Kim, J.Y., Lee, H.J., Gi, M., Kim, G.B., and Choi, J.Y. (2014). Autoimmunity as a candidate for the etiopathogenesis of Meniere\u2019s disease: Detection of autoimmune reactions and diagnostic biomarker candidate. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111039"},{"key":"ref_39","first-page":"MC01","article-title":"Incidence of Hypothyroidism in Meniere\u2019s Disease","volume":"10","author":"Santosh","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000218357","article-title":"Elevated antithyroid peroxidase and antinuclear autoantibody titers in M\u00e9ni\u00e8re\u2019s disease patients: More than a chance association?","volume":"15","author":"Nacci","year":"2010","journal-title":"Audiol. Neurootol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6771\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:08Z","timestamp":1760145548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":40,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jcm11226771"],"URL":"https:\/\/doi.org\/10.3390\/jcm11226771","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]}}}