{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:52:19Z","timestamp":1779317539663,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Esophageal pressure (Pes) measurements could optimise ventilator parameters in acute respiratory failure (ARF) patients requiring noninvasive ventilation (NIV). Consequently, the objectives of our study were to evaluate the safety and accuracy of applying a Pes measuring protocol in ARF patients with AECOPD under NIV in our respiratory intermediate care unit (RICU). An observational cohort study was undertaken. The negative inspiratory swing of Pes (\u0394Pes) was measured: in an upright\/supine position in the presence\/absence of NIV at D1 (day of admission), D3 (3rd day of NIV), and DoD (day of discharge). A digital filter for artefact removal was developed. We included 15 patients. The maximum values for \u2206Pes were recorded at admission (mean \u2206Pes 23.2 cm H2O) in the supine position. \u2206Pes decreased from D1 to D3 (p &lt; 0.05), the change being BMI-dependent (p &lt; 0.01). The addition of NIV decreased \u2206Pes at D1 and D3 (p &lt; 0.01). The reduction of \u2206Pes was more significant in the supine position at D1 (8.8 cm H2O, p &lt; 0.01). Under NIV, \u2206Pes values remained higher in the supine versus upright position. Therefore, the measurement of Pes in AECOPD patients requiring NIV can be safely done in an RICU. Under NIV, \u2206Pes reduction is most significant within the first 24 h of admission.<\/jats:p>","DOI":"10.3390\/jcm11226810","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T06:02:29Z","timestamp":1668751349000},"page":"6810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Esophageal Pressure Measurement in Acute Hypercapnic Respiratory Failure Due to Severe COPD Exacerbation Requiring NIV\u2014A Pilot Safety Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Alexandru Tudor","family":"Steriade","sequence":"first","affiliation":[{"name":"Department of Pneumology & Acute Respiratory Care, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"},{"name":"Department of Cardio-thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Gologanu","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development in Microtechnologies, 077190 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-1159","authenticated-orcid":false,"given":"Roxana Silvia","family":"Bumbacea","sequence":"additional","affiliation":[{"name":"Department of Allergy, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan Nicolae","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Department of Cardio-thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Cardiology, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-3835","authenticated-orcid":false,"given":"Dragos","family":"Bumbacea","sequence":"additional","affiliation":[{"name":"Department of Pneumology & Acute Respiratory Care, \u201cElias\u201d Emergency University Hospital, 011461 Bucharest, Romania"},{"name":"Department of Cardio-thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1164\/rccm.201312-2193CI","article-title":"The application of esophageal pressure measurement in patients with respiratory failure","volume":"189","author":"Akoumianaki","year":"2014","journal-title":"Am. 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