{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:36:47Z","timestamp":1762076207093,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heidelberg University Hospital and Hospital Bergstrasse"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Extracorporeal hemadsorption eliminates proinflammatory mediators in critically ill patients with hyperinflammation. The use of a pumpless extracorporeal hemadsorption technique allows its early usage prior to organ failure and the need for an additional medical device. In our animal model, we investigated the feasibility of pumpless extracorporeal hemadsorption over a wide range of mean arterial pressures (MAP). Methods: An arteriovenous shunt between the femoral artery and femoral vein was established in eight pigs. The hemadsorption devices were inserted into the shunt circulation; four pigs received CytoSorb\u00ae and four Oxiris\u00ae hemadsorbers. Extracorporeal blood flow was measured in a range between mean arterial pressures of 45\u201385 mmHg. Mean arterial pressures were preset using intravenous infusions of noradrenaline, urapidil, or increased sedatives. Results: Extracorporeal blood flows remained well above the minimum flows recommended by the manufacturers throughout all MAP steps for both devices. Linear regression resulted in CytoSorb\u00ae blood flow [mL\/min] = 4.226 \u00d7 MAP [mmHg] \u2212 3.496 (R-square 0.8133) and Oxiris\u00ae blood flow [mL\/min] = 3.267 \u00d7 MAP [mmHg] + 57.63 (R-square 0.8708), respectively. Conclusion: Arteriovenous pumpless extracorporeal hemadsorption resulted in sufficient blood flows through both the CytoSorb\u00ae and Oxiris\u00ae devices over a wide range of mean arterial blood pressures and is likely an intriguing therapeutic option in the early phase of septic shock or hyperinflammatory syndromes.<\/jats:p>","DOI":"10.3390\/jcm11226815","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T06:02:29Z","timestamp":1668751349000},"page":"6815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pumpless Extracorporeal Hemadsorption Technique (pEHAT): A Proof-of-Concept Animal Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-2783","authenticated-orcid":false,"given":"Mascha O.","family":"Fiedler","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf M.","family":"Muellenbach","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine, Emergency Medicine and Pain Therapy, Campus Kassel of the University of Southampton, 34125 Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Rolfes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine, Emergency Medicine and Pain Therapy, Campus Kassel of the University of Southampton, 34125 Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2574-624X","authenticated-orcid":false,"given":"Christopher","family":"Lotz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat P.","family":"M\u00fcller-Stich","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-3652","authenticated-orcid":false,"given":"Alexander","family":"Supady","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"},{"name":"Department of Cardiology and Angiology I, Heart Center, University of Freiburg, 79106 Freiburg, Germany"},{"name":"Heidelberg Institute of Global Health, University of Heidelberg, 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3620-0912","authenticated-orcid":false,"given":"Philipp M.","family":"Lepper","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V\u2014Pneumology, Allergology and Critical Care Medicine, University Medical Centre, Saarland University, 66424 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus A.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-8696","authenticated-orcid":false,"given":"Patrick","family":"Meybohm","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-481X","authenticated-orcid":false,"given":"Armin","family":"Kalenka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hospital Bergstrasse, 64646 Heppenheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Reyher","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine, Emergency Medicine and Pain Therapy, Campus Kassel of the University of Southampton, 34125 Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2478\/jccm-2020-0036","article-title":"Hemoadsorption in Critical Care\u2014It is a Useful or a Harmful Technique?","volume":"6","author":"Kovacs","year":"2020","journal-title":"J. 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Scand."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6815\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:45Z","timestamp":1760145645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/22\/6815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":19,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jcm11226815"],"URL":"https:\/\/doi.org\/10.3390\/jcm11226815","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2022,11,18]]}}}