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Development Program in Weifang City","award":["2019WS594\/202002010572"],"award-info":[{"award-number":["2019WS594\/202002010572"]}]},{"name":"Science and Technology Development Program in Weifang City","award":["2021YX042"],"award-info":[{"award-number":["2021YX042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Post-Traumatic Stress Disorder (PTSD) is a severe psychological disorder characterized by intrusive thoughts, heightened arousal, avoidance, and flashbacks. Cognitive flexibility dysfunction has been linked with the emergence of PTSD, including response inhibition deficits and impaired attentional switching, which results in difficulties for PTSD patients when disengaging attention from trauma-related stimuli. However, the molecular mechanisms of cognitive flexibility deficits remain unclear. Methods: The animals were exposed to a single prolonged stress and electric foot shock (SPS&amp;S) procedure to induce PTSD-like features. Once the model was established, the changes in cognitive flexibility were assessed using an attentional set-shifting task (ASST) in order to investigate the effects of traumatic stress on cognitive flexibility. Additionally, the molecular alterations of certain proteins (AMPA Receptor 1 (GluA1), brain-derived neurotrophic factor (BDNF), and Postsynaptic density protein 95 (PSD95) in the medial prefrontal cortex (mPFC) were measured using Western blot and immunofluorescence. Results: The SPS&amp;S model exhibited PTSD-like behaviors and induced reversal learning and set-shifting ability deficit in the ASST. These behavioral changes are accompanied by decreased GluA1, BDNF, and PSD95 protein expression in the mPFC. Further analysis showed a correlative relationship between the behavioral and molecular alterations. Conclusions: The SPS&amp;S model induced cognitive flexibility deficits, and the potential underlying mechanism could be mediated by GluA1-related BDNF signaling in the mPFC.<\/jats:p>","DOI":"10.3390\/jcm11226824","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:33:32Z","timestamp":1669005212000},"page":"6824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The GluA1-Related BDNF Pathway Is Involved in PTSD-Induced Cognitive Flexibility Deficit in Attentional Set-Shifting Tasks of Rats"],"prefix":"10.3390","volume":"11","author":[{"given":"Jiaming","family":"Sun","sequence":"first","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keli","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingtao","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital\/Institute of Mental Health and the Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Extended Education, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Mental Health Centre of Weifang City, Weifang 261071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Technology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongde","family":"Du","sequence":"additional","affiliation":[{"name":"Cerebral Center, Sunshine Union Hospital, 9000# Yingqian Street, Weifang 261205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1176\/ajp.152.1.116","article-title":"Arousal, numbing, and intrusion: Symptom structure of PTSD following assault","volume":"152","author":"Foa","year":"1995","journal-title":"Am. 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