{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:22:33Z","timestamp":1793978553894,"version":"4.8.0"},"reference-count":42,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Multiple vaccines are now being used across the world, and several studies have described cases of corneal graft rejection following the administration of the COVID-19 vaccine. The purpose of this article is to review the corneal adverse event that occurred following COVID-19 vaccine administration. The literature search was conducted in March 2022 using MEDLINE, PubMed, and the Cochrane Database of Systematic Reviews. A total of 27 articles, including 37 cases, have documented corneal adverse events that occurred following COVID-19 vaccination. The mean age was 60 \u00b1 14.9 years (range, 27\u201383 years). The most common events were acute corneal graft rejection (n = 21, 56.8%), followed by herpes zoster ophthalmicus (n = 11, 29.7%) and herpes simplex keratitis (n = 2, 5.4%). The mean time from vaccination to the event was 10 \u00b1 8.5 days (range, 1\u201342 days) after the first or second dose of vaccine. All patients with corneal graft rejection, immune-mediated keratolysis, and peripheral ulcerative keratitis (PUK) (n = 24, 64.9%) were managed topically with or without oral corticosteroids. Patients with herpes zoster ophthalmicus and herpes simplex keratitis were managed with oral antiviral agents. Two patients received penetrating keratoplasty due to keratolysis after invalid topical treatment. Disease resolution was noted in 29 patients (78.3%), whereas 3 (8.1%) had persistent corneal edema after graft rejection, 1 (2.7%) had corneal infiltration after HZO, and 4 (10.8%) were not mentioned in the articles. Corneal adverse events could occur after COVID-19 vaccination. After timely treatment with steroids or antiviral agents, most of the events were mild and had a good visual outcome. Administrating or increasing steroids before vaccination may be useful for the prevention of corneal graft rejection. However, the prophylactic use of antiviral treatments in patients with a herpes viral infection history is not recommend.<\/jats:p>","DOI":"10.3390\/jcm11226828","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:33:32Z","timestamp":1669005212000},"page":"6828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Corneal Complications after COVID-19 Vaccination: A Systemic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-7895","authenticated-orcid":false,"given":"Li-Ying","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-1051","authenticated-orcid":false,"given":"Chun-Chi","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Optometry, Asia University, Taichung 413305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-4468","authenticated-orcid":false,"given":"Hung-Yin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ching","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-9741","authenticated-orcid":false,"given":"Ying-Hsuen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Optometry, Asia University, Taichung 413305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajo.2022.02.011","article-title":"COVID-19 Vaccination and The Eye","volume":"240","author":"Wang","year":"2022","journal-title":"Am. 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