{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:17:05Z","timestamp":1792181825952,"version":"4.4.0"},"reference-count":25,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Edwards Lifesciences","award":["(949) 250-2500"],"award-info":[{"award-number":["(949) 250-2500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The majority of patients admitted to the intensive care unit (ICU) experience severe hypotension which is associated with increased morbidity and mortality. At present, prospective studies examining the incidence and severity of hypotension using continuous waveforms are missing. Methods: This study is a prospective observational cohort study in a mixed surgical and non-surgical ICU population. All patients over 18 years were included and continuous arterial pressure waveforms data were collected. Mean arterial pressure (MAP) below 65 mmHg for at least 10 s was defined as hypotension and a MAP below 45 mmHg as severe hypotension. The primary outcome was the incidence of hypotension. Secondary outcomes were the severity of hypotension expressed in time-weighted average (TWA), factors associated with hypotension, the number and duration of hypotensive events. Results: 499 patients were included. The incidence of hypotension (MAP &lt; 65 mmHg) was 75% (376 out of 499) and 9% (46 out of 499) experienced severe hypotension. Median TWA was 0.3 mmHg [0\u20131.0]. Associated clinical factors were age, male sex, BMI and cardiogenic shock. There were 5 (1\u201312) events per patients with a median of 52 min (5\u2013170). Conclusions: In a mixed surgical and non-surgical ICU population the incidence of hypotension is remarkably high.<\/jats:p>","DOI":"10.3390\/jcm11226832","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:33:32Z","timestamp":1669005212000},"page":"6832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence, Severity and Clinical Factors Associated with Hypotension in Patients Admitted to an Intensive Care Unit: A Prospective Observational Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-9348","authenticated-orcid":false,"given":"Lotte E.","family":"Terwindt","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7471-8304","authenticated-orcid":false,"given":"Jaap","family":"Schuurmans","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn J. P.","family":"van der Ster","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin A. G. C. L.","family":"Wensing","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-0046","authenticated-orcid":false,"given":"Marijn P.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Cardiovascular and Respiratory Physiology Group, Technical Medical Center, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"Wijnberge","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G. V.","family":"Cherpanath","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-1961","authenticated-orcid":false,"given":"Wim K.","family":"Lagrand","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain A.","family":"Karlas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Verlinde","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-0244","authenticated-orcid":false,"given":"Markus W.","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart F.","family":"Geerts","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise P.","family":"Veelo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-7186","authenticated-orcid":false,"given":"Alexander P. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","unstructured":"Barrett, M.L., Smith, M.W., Elixhauser, A., Honigman, L.S., and Pines, J.M. (2006). 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