{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:48:20Z","timestamp":1762508900624,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"],"award-info":[{"award-number":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Senior Medical Talents Program of Chongqing for Young and Middle-aged","award":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"],"award-info":[{"award-number":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"]}]},{"name":"the Chongqing Science and Technology Committee","award":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"],"award-info":[{"award-number":["82200829","cstc2018jscx-msybX0120","CSTB2022NSCQ-MSX0322"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: To compare the safety and efficacy of percutaneous paricalcitol injection with intravenously administered paricalcitol in treating parathyroid hyperplasia in patients with secondary hyperparathyroidism (SHPT). Methods: This study was approved by the Ethics Committee of our institution. We retrospectively collected data on patients who received percutaneous paricalcitol injection (24 patients) and intravenously administered paricalcitol (22 patients) based on their intact parathyroid hormone (iPTH) level. Serum iPTH, calcium, phosphorus, and the volume of the parathyroid gland were measured at several indicated time points after treatment, and adverse events associated with the two treatments were evaluated. Results: After 6 months of follow-up, we found that patients from the percutaneous injection group had significantly decreased levels of iPTH (from 1887.81 \u00b1 726.81 pg\/mL to 631.06 \u00b1 393.06 pg\/mL), phosphate (from 1.94 \u00b1 0.36 mmol\/L to 1.71 \u00b1 0.34 mmol\/L), and volume of the parathyroid gland (from 0.87 \u00b1 0.50 cm3 to 0.60 \u00b1 0.36 cm3), with relief from ostealgia within 48\u201372 h. In the intravenously administered group, the levels of iPTH decreased from 686.87 \u00b1 260.44 pg\/mL to 388.47 \u00b1 167.36 pg\/mL; while there was no significant change in phosphate levels, the volume of the parathyroid gland and ostealgia relief were observed at the end of follow-up. The serum calcium level did not significantly change, and no severe complications were observed in both groups. In vitro fluorescence-activated single cell sorting (FACS) analysis indicated that paricalcitol induced parathyroid cell apoptosis in a dose-dependent manner. Conclusions: Percutaneous paricalcitol injection is a selective treatment for SHPT in ESRD.<\/jats:p>","DOI":"10.3390\/jcm11226860","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:33:32Z","timestamp":1669005212000},"page":"6860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness and Safety of Ultrasound-Guided Local Paricalcitol Injection in Treating Secondary Hyperparathyroidism in ESRD: A Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Shuqin","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Yongchuan People\u2019s Hospital of Chongqing, Chongqing 402160, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dianjiang People\u2019s Hospital of Chongqing, Chongqing 408300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[{"name":"The Department of Nephrology, The Fifth Hospital of Chongqing, Chongqing 400062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hematopathology, Second Affiliated Hospital at Fengjie, Chongqing Medical University, Chongqing 404600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, People\u2019s Hospital of Pengshui County, Chongqing 409600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, People\u2019s Hospital of Shizhu County, Chongqing 409100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dianjiang People\u2019s Hospital of Chongqing, Chongqing 408300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghui","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fengdu People\u2019s Hospital, Chongqing 408200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2215\/CJN.12941213","article-title":"Recent Changes in Therapeutic Approaches and Association with Outcomes among Patients with Secondary Hyperparathyroidism on Chronic Hemodialysis: The DOPPS Study","volume":"10","author":"Tentori","year":"2015","journal-title":"Clin. 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