{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:21:11Z","timestamp":1791991271787,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leona M. and Harry B. Helmsley Charitable Trust","award":["2018PG-CD007"],"award-info":[{"award-number":["2018PG-CD007"]}]},{"name":"ECCO-AOCC","award":["2018PG-CD007"],"award-info":[{"award-number":["2018PG-CD007"]}]},{"name":"IOIBD","award":["2018PG-CD007"],"award-info":[{"award-number":["2018PG-CD007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Crohn\u2019s disease (CD) incidence is rising in India. However, features of newly diagnosed patients with CD in this population are largely unknown. The Indo-Israeli IBD GastroEnterology paRtnership (TiiiGER) aimed to investigate differences in presentation among patients with newly diagnosed CD in India and Israel, and to explore phenotype\u2013serotype correlations. Methods: A prospective observational cohort study of consecutive adults (&gt;18 years) conducted in two large referral centers in India and Israel (2014\u20132018). Clinical data, an antiglycan serological panel, and 20 CD-associated genetic variants were analyzed. Outcomes: complicated phenotype at diagnosis and early complicated course (hospitalizations\/surgeries) within 2 years of diagnosis. Results: We included 260 patients (104, Indian (65.4%, male; age, 37.8); 156 Israeli (49.4%, male; 31.8, age)). Median lag time from symptoms onset to diagnosis was 10.5 (IQR 3\u201338) vs. 3 (IQR 1\u20138) months in Indian vs. Israeli patients (p &lt; 0.001). Complicated phenotype at diagnosis was observed in 48% of Indian and 30% of Israeli patients (p = 0.003). Complicated phenotype was associated with higher anti-Saccharomyces cerevisiae antibody (ASCA) seropositivity rate among Israeli patients (p &lt; 0.001), but not among Indian patients. Antiglycan serology did not correlate with the tested genetic variants. Early complicated course occurred in 28 (18%) Israeli and 13 (12.5%) Indian patients. The time from diagnosis to complication was comparable (log rank p = 0.152). Antiglycan serology did not correlate with a complicated early course in either cohort. Conclusions: There are significant differences in patients presenting with newly diagnosed CD in India and Israel, including phenotype and distinct biomarkers at diagnosis. These differences suggest different genetic and environmental disease modifiers.<\/jats:p>","DOI":"10.3390\/jcm11236899","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T03:15:24Z","timestamp":1669173324000},"page":"6899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Newly Diagnosed Crohn\u2019s Disease Patients in India and Israel Display Distinct Presentations and Serological Markers: Insights from Prospective Cohorts"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-2840","authenticated-orcid":false,"given":"Idan","family":"Goren","sequence":"first","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"},{"name":"Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Sharar Fischler","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-5271","authenticated-orcid":false,"given":"Henit","family":"Yanai","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-9004","authenticated-orcid":false,"given":"Partha","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 501301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Adigopula","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 501301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmitha","family":"Pendyala","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 501301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 501301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikanth","family":"Vishnubhotla","sequence":"additional","affiliation":[{"name":"Department of Genomics and Molecular Biology, Institute of Translational Research, Asian Institute of Gastroenterology and AIG Hospitals, Hyderabad 500032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren Masha","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"},{"name":"Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Hospital Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49414, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Shaham Barda","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"},{"name":"Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Hospital Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49414, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durga","family":"Yadamreddy","sequence":"additional","affiliation":[{"name":"Department of Genomics and Molecular Biology, Institute of Translational Research, Asian Institute of Gastroenterology and AIG Hospitals, Hyderabad 500032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-6466","authenticated-orcid":false,"given":"Lihi","family":"Godny","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Peleg","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 501301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Dotan","sequence":"additional","affiliation":[{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases with Time, Based on Systematic Review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.3748\/wjg.v22.i36.8123","article-title":"Inflammatory bowel disease in India\u2014Past, present and future","volume":"22","author":"Ray","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000465522","article-title":"Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East","volume":"2","author":"Kedia","year":"2017","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12664-017-0809-6","article-title":"Multi-center prospective survey of inflammatory bowel diseases in Kerala: More than 2000 cases","volume":"36","author":"Philip","year":"2017","journal-title":"Indian J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12664-012-0258-1","article-title":"Survey of inflammatory bowel diseases in India","volume":"31","author":"Makharia","year":"2012","journal-title":"Indian J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1440-1746.2012.07150.x","article-title":"Inflammatory bowel disease in Asia: A systematic review","volume":"27","author":"Prideaux","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/ecco-jcc\/jjv202","article-title":"Temporal Change in Phenotypic Behaviour in Patients with Crohn\u2019s Disease: Do Indian Patients Behave Differently from Western and Other Asian Patients?","volume":"10","author":"Kalaria","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/MCG.0000000000001282","article-title":"IBD in India: Similar phenotype but different demographics than the west","volume":"54","author":"Banerjee","year":"2020","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S2468-1253(20)30299-5","article-title":"Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia","volume":"5","author":"Banerjee","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/apt.14617","article-title":"Risk factors for diagnostic delay in Crohn\u2019s disease and their impact on long-term complications: How do they differ in a tuberculosis endemic region?","volume":"47","author":"Banerjee","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/j.gastro.2006.04.030","article-title":"Antibodies Against Laminaribioside and Chitobioside Are Novel Serologic Markers in Crohn\u2019s Disease","volume":"131","author":"Dotan","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.2006.108043","article-title":"New serological markers in inflammatory bowel disease are associated with complicated disease behaviour","volume":"56","author":"Ferrante","year":"2007","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0140-6736(02)08590-2","article-title":"Association of NOD2 (CARD 15) genotype with clinical course of Crohn\u2019s disease: A cohort study","volume":"359","author":"Hampe","year":"2002","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.gene.2012.10.015","article-title":"NOD2 gene mutations associate weakly with ulcerative colitis but not with Crohn\u2019s disease in Indian patients with inflammatory bowel disease","volume":"512","author":"Pugazhendhi","year":"2013","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"A222","DOI":"10.1136\/gut.2011.239301.469","article-title":"How helpful are serological markers in differentiating crohn\u2019s disease from ulcerative colitis in indian asian inflammatory bowel disease patients?","volume":"60","author":"Walker","year":"2011","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications","volume":"55","author":"Satsangi","year":"2006","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pugazhendhi, S., Baskaran, K., Santhanam, S., and Ramakrishna, B.S. (2017). Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178291"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Baskaran, K., Pugazhendhi, S., and Ramakrishna, B.S. (2014). Association of IRGM Gene Mutations with Inflammatory Bowel Disease in the Indian Population. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106863"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"262\u2013268","DOI":"10.1038\/ng.3755","article-title":"Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn\u2019s disease","volume":"49","author":"Lee","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/apt.13460","article-title":"A validated web-based tool to display individualised Crohn\u2019s disease predicted outcomes based on clinical, serologic and genetic variables","volume":"43","author":"Siegel","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ajg.2011.19","article-title":"The Prognostic Power of the NOD2 Genotype for Complicated Crohn\u2019s Disease: A Meta-Analysis","volume":"106","author":"Adler","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/gene.2009.25","article-title":"Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: A meta-analysis approach","volume":"10","author":"Oliver","year":"2009","journal-title":"Genes Immun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00054725-200409000-00005","article-title":"Disease Location, Anti-Saccharomyces cerevisiae Antibody, and NOD2\/CARD15 Genotype Influence the Progression of Disease Behavior in Crohn\u2019s Disease","volume":"10","author":"Smith","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_27","first-page":"336","article-title":"Genotype\u2013Serotype Interactions Shed Light on Genetic Components of Inflammatory Bowel Diseases","volume":"25","author":"Finezilber","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gutjnl-2017-315568","article-title":"Natural disease course of Crohn\u2019s disease during the first 5 years after diagnosis in a European population-based inception cohort: An Epi-IBD study","volume":"68","author":"Burisch","year":"2018","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2010.06.070","article-title":"Risk Factors Associated with Progression to Intestinal Complications of Crohn\u2019s Disease in a Population-Based Cohort","volume":"139","author":"Thia","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/gutjnl-2015-310545","article-title":"Dual role of Helicobacter and Campylobacter species in IBD: A systematic review and meta-analysis","volume":"66","author":"Kaakoush","year":"2017","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/ajg.2011.85","article-title":"Differences in Inflammatory Bowel Disease Phenotype between South Asians and Northern Europeans Living in North West London, UK","volume":"106","author":"Walker","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ajg.2016.59","article-title":"Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation, and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease","volume":"111","author":"Gracie","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/gut.31.5.536","article-title":"Antibody to selected strains of Saccharomyces cerevisiae (baker\u2019s and brewer\u2019s yeast) and Candida albicans in Crohn\u2019s disease","volume":"31","author":"McKenzie","year":"1990","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ibd.20539","article-title":"Intestinal barrier dysfunction in inflammatory bowel diseases","volume":"15","author":"McGuckin","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/ibd.21179","article-title":"Serum anti-glycan antibodies predict complicated Crohn\u2019s disease behavior","volume":"16","author":"Rieder","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_36","first-page":"33","article-title":"Anti-Saccharomyces cerevisiae Antibody Does Not Differentiate Between Crohn\u2019s Disease and Intestinal Tuberculosis","volume":"52","author":"Makharia","year":"2006","journal-title":"Am. J. Dig. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.3748\/wjg.v19.i37.6207","article-title":"Inflammatory bowel disease serology in Asia and the West","volume":"19","author":"Prideaux","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/01.MIB.0000182872.76434.8c","article-title":"A Comparative Study of Goblet Cell and Pancreatic Exocine Autoantibodies Combined with ASCA and pANCA in Chinese and Caucasian Patients with IBD","volume":"11","author":"Lawrance","year":"2005","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s005350300020","article-title":"Anti- Saccharomyces cerevisiae antibodies in Japanese patients with inflammatory bowel disease: Diagnostic accuracy and clinical value","volume":"38","author":"Hisabe","year":"2003","journal-title":"J. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1111\/j.1572-0241.2004.40486.x","article-title":"A Prospective Comparative Study of ASCA and pANCA in Chinese and Caucasian IBD Patients","volume":"99","author":"Lawrance","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.dld.2007.03.006","article-title":"Clinical significance of anti-Saccharomyces cerevisiae antibody (ASCA) in Korean patients with Crohn\u2019s disease and its relationship to the disease clinical course","volume":"39","author":"Kim","year":"2007","journal-title":"Dig. Liver Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/ibd.22884","article-title":"Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn\u2019s disease","volume":"18","author":"Murdoch","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1136\/gutjnl-2011-300777","article-title":"Genetic factors conferring an increased susceptibility to develop Crohn\u2019s disease also influence disease phenotype: Results from the IBDchip European Project","volume":"62","author":"Cleynen","year":"2013","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Schnitzler, F., Friedrich, M., Wolf, C., Angelberger, M., Diegelmann, J., Olszak, T., Beigel, F., Tillack, C., Stallhofer, J., and G\u00f6ke, B. (2014). The NOD2 p.Leu1007fsX1008 Mutation (rs2066847) Is a Stronger Predictor of the Clinical Course of Crohn\u2019s Disease than the FOXO3A Intron Variant rs12212067. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108503"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2013.04.007","article-title":"Incidence and Phenotype of Inflammatory Bowel Disease Based on Results from the Asia-Pacific Crohn\u2019s and Colitis Epidemiology Study","volume":"145","author":"Ng","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: East meets west","volume":"35","author":"Mak","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/gutjnl-2011-301397","article-title":"Hospitalisations and surgery in Crohn\u2019s disease","volume":"61","author":"Bernstein","year":"2012","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/gut.2009.202101","article-title":"Natural history of Crohn\u2019s disease in a population-based cohort from Cardiff (1986-2003): A study of changes in medical treatment and surgical resection rates","volume":"59","author":"Ramadas","year":"2010","journal-title":"Gut"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.gastro.2020.03.039","article-title":"Deep Remission at 1 Year Prevents Progression of Early Crohn\u2019s Disease","volume":"159","author":"Ungaro","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2015.11.029","article-title":"The Changing Landscape of Inflammatory Bowel Disease: East Meets West","volume":"150","author":"Kaplan","year":"2016","journal-title":"Gastroenterology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/6899\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:24:37Z","timestamp":1760145877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/23\/6899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,22]]},"references-count":50,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcm11236899"],"URL":"https:\/\/doi.org\/10.3390\/jcm11236899","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,22]]}}}